Oral microbiome and risk of incident head and neck cancer: A nested case-control study

Wu, Zeni; Han, Yongli; Wan, Yunhu; Hua, Xing; Chill, Samantha S; Teshome, Kedest; Zhou, Weiyin; Liu, Jia; Wu, Dongjing; Hutchinson, Amy; Jones, Kristine; Dagnall, Casey; Hicks, Belynda; Liao, Linda M.; Hallen‐Adams, Heather E.; Shi, Jianxin; Abnet, Christian C.; Sinha, Rashmi; Chaturvedi, Anil K.; Vogtmann, Emily

doi:10.1016/j.oraloncology.2022.106305

Cited by 10 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another recent nested case-control study aiming to investigate the relationship of oral microbiome with HNC demonstrated that the presence of oral fungi and relative abundance of multiple microbial species, including the red- and orange-complex periodontal pathogens ( C. albicans , K. oralis , P. gingivalis ), were associated with reduced risk of HNC ( 53 ).…”

Section: Oral Microbiota Dysbiosis and Pathogenesis Of Hncsmentioning

confidence: 99%

“…Therefore, in this review, we discussed first the most recent original paper and clinical trials aiming to investigate the human microbiota signatures associated with HNC and human microbiota signatures associated with a reduced risk of HNC. Secondly, we discussed the potential microbiome-derived biomarkers for HNCs diagnosis and implications of oro-pharyngeal dysbiosis in HNCs therapy, presenting the results from the very recent studies over the past two years ( 36 – 53 ). Finally, we discussed the contribution of HPV infection to HNCs initiation and progress and implications for prevention, early diagnosis, and treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy

Constantin,

Chifiriuc,

Mihaescu

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

Head and neck cancer (HNC) is the sixth most common type of cancer, with more than half a million new cases annually. This review focuses on the role of oral dysbiosis and HPV infection in HNCs, presenting the involved taxons, molecular effectors and pathways, as well as the HPV-associated particularities of genetic and epigenetic changes and of the tumor microenvironment occurred in different stages of tumor development. Oral dysbiosis is associated with the evolution of HNCs, through multiple mechanisms such as inflammation, genotoxins release, modulation of the innate and acquired immune response, carcinogens and anticarcinogens production, generation of oxidative stress, induction of mutations. Thus, novel microbiome-derived biomarkers and interventions could significantly contribute to achieving the desideratum of personalized management of oncologic patients, regarding both early diagnosis and treatment. The results reported by different studies are not always congruent regarding the variations in the abundance of different taxons in HNCs. However, there is a consistent reporting of a higher abundance of Gram-negative species such as Fusobacterium, Leptotrichia, Treponema, Porphyromonas gingivalis, Prevotella, Bacteroidetes, Haemophilus, Veillonella, Pseudomonas, Enterobacterales, which are probably responsible of chronic inflammation and modulation of tumor microenvironment. Candida albicans is the dominant fungi found in oral carcinoma being also associated with shorter survival rate. Specific microbial signatures (e.g., F. nucleatum, Bacteroidetes and Peptostreptococcus) have been associated with later stages and larger tumor, suggesting their potential to be used as biomarkers for tumor stratification and prognosis. On the other hand, increased abundance of Corynebacterium, Kingella, Abiotrophia is associated with a reduced risk of HNC. Microbiome could also provide biomarkers for differentiating between oropharyngeal and hypopharyngeal cancers as well as between HPV-positive and HPV-negative tumors. Ongoing clinical trials aim to validate non-invasive tests for microbiome-derived biomarkers detection in oral and throat cancers, especially within high-risk populations. Oro-pharyngeal dysbiosis could also impact the HNCs therapy and associated side-effects of radiotherapy, chemotherapy, and immunotherapy. HPV-positive tumors harbor fewer mutations, as well as different DNA methylation pattern and tumor microenvironment. Therefore, elucidation of the molecular mechanisms by which oral microbiota and HPV infection influence the HNC initiation and progression, screening for HPV infection and vaccination against HPV, adopting a good oral hygiene, and preventing oral dysbiosis are important tools for advancing in the battle with this public health global challenge.

show abstract

Section: Oral Microbiota Dysbiosis and Pathogenesis Of Hncsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy

Constantin,

Chifiriuc,

Mihaescu

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer

Kwak,

Wang,

Usyk

et al. 2024

JAMA Oncol

View full text Add to dashboard Cite

ImportanceThe oral microbiota may be involved in development of head and neck squamous cell cancer (HNSCC), yet current evidence is largely limited to bacterial 16S amplicon sequencing or small retrospective case-control studies.ObjectiveTo test whether oral bacterial and fungal microbiomes are associated with subsequent risk of HNSCC development.Design, Setting, and ParticipantsProspective nested case-control study among participants providing oral samples in 3 epidemiological cohorts, the American Cancer Society Cancer Prevention Study II Nutrition Cohort, the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, and the Southern Community Cohort Study. Two hundred thirty-six patients who prospectively developed HNSCC were identified during a mean (SD) of 5.1 (3.6) years of follow-up. Control participants who remained HNSCC free were selected by 2:1 frequency matching on cohort, age, sex, race and ethnicity, and time since oral sample collection. Data analysis was conducted in 2023.ExposuresCharacterization of the oral bacterial microbiome using whole-genome shotgun sequencing and the oral fungal microbiome using internal transcribed spacer sequencing. Association of bacterial and fungal taxa with HNSCC was assessed by analysis of compositions of microbiomes with bias correction. Association with red and orange oral pathogen complexes was tested by logistic regression. A microbial risk score for HNSCC risk was calculated from risk-associated microbiota.Main Outcomes and MeasuresThe primary outcome was HNSCC incidence.ResultsThe study included 236 HNSCC case participants with a mean (SD) age of 60.9 (9.5) years and 24.6% women during a mean of 5.1 (3.6) years of follow-up, and 485 matched control participants. Overall microbiome diversity at baseline was not related to subsequent HNSCC risk; however 13 oral bacterial species were found to be differentially associated with development of HNSCC. The species included the newly identified Prevotella salivae, Streptococcus sanguinis, and Leptotrichia species, as well as several species belonging to beta and gamma Proteobacteria. The red/orange periodontal pathogen complex was moderately associated with HNSCC risk (odds ratio, 1.06 per 1 SD; 95% CI, 1.00-1.12). A 1-SD increase in microbial risk score (created based on 22 bacteria) was associated with a 50% increase in HNSCC risk (multivariate odds ratio, 1.50; 95% CI, 1.21-1.85). No fungal taxa associated with HNSCC risk were identified.Conclusions and RelevanceThis case-control study yielded compelling evidence that oral bacteria are a risk factor for HNSCC development. The identified bacteria and bacterial complexes hold promise, along with other risk factors, to identify high-risk individuals for personalized prevention of HNSCC.

show abstract

The role of the microbiome in head and neck squamous cell cancers

Sahin,

Sonmezer

2024

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Oral microbiome and risk of incident head and neck cancer: A nested case-control study

Cited by 10 publications

References 47 publications

Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy

Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy

Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer

The role of the microbiome in head and neck squamous cell cancers

Contact Info

Product

Resources

About