Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis

Li, Simin; He, Meiling; Lei, Yu-Meng; Liu, Yang; Li, Xinquan; Xiang, Xiaochen; Wu, Qingming; Wang, Qiang

doi:10.3390/microorganisms10112206

Cited by 15 publications

(5 citation statements)

References 154 publications

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“…Oral microorganisms have the ability to colonize extra-oral organs, such as the lungs, colorectum, and stomach (Park et al, 2021). They employ their own virulence factors and metabolites to disrupt the epithelial barrier and extracellular matrix, induce an inflammatory microenvironment and immunosuppressive tumor microenvironment, thereby influencing both local and distant tumors (Li S. et al, 2022;Ma et al, 2023). The anaerobic conditions within the tumor microenvironment further facilitate the accumulation of anaerobic oral microorganisms in tumors (Wu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

The role of oral microbiota in cancer

Lan,

Liu,

Cui

et al. 2023

Front. Microbiol.

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Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor for cancer development. The oral cavity, second only to the colon, harbors more than 700 bacterial species and serves as a crucial microbial habitat. Although numerous epidemiological studies have reported associations between oral microorganisms and major systemic tumors, the relationship between oral microorganisms and cancers remains largely unclear. Current research primarily focuses on respiratory and digestive system tumors due to their anatomical proximity to the oral cavity. The relevant mechanism research mainly involves 47% dominant oral microbial population that can be cultured in vitro. However, further exploration is necessary to elucidate the mechanisms underlying the association between oral microbiota and tumors. This review systematically summarizes the reported correlations between oral microbiota and common cancers while also outlining potential mechanisms that may guide biological tumor treatment.

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Section: Discussionmentioning

confidence: 99%

The role of oral microbiota in cancer

Lan,

Liu,

Cui

et al. 2023

Front. Microbiol.

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“…On the one hand, the dysbiosis of bacterial communities affects tumor development, mainly through chronic inflammation and immunosuppression, and certain oral microbiota and their metabolites have tumor‐promoting properties. On the other hand, specific tumor microenvironments also make great contributions to microbiota colonization (Li et al., 2022). Take F. nucleatum for instance, it was confirmed that its colonization to breast cancer is secondary to tumor initiation in mice experiments (Parhi et al., 2020).…”

Section: The Ways F Nucleatum Translocates To the Breast Tissue And C...mentioning

confidence: 99%

“…pathogens usually affect the mechanism of epithelial barrier function by the following mechanisms: (1) manipulating barrier-related genes or proteins to promote adhesion and internalization; (2) directly disrupting junctions and penetrating into underlying tissue. Moreover, the representative pathogens include F. nucleatum, T. forsythus, and Aggregatibacter actinomycetemcomitans(Abdulkareem et al, 2018;Li et al, 2022). The oral opportunistic pathogen, F. nucleatum, can bind and invade epithelial and endothelial cells through its virulence factors such as FadA, Fap2, and Fusobacterium outer membrane protein A, thus adhering to different sites.…”

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confidence: 99%

The ways Fusobacterium nucleatum translocate to breast tissue and contribute to breast cancer development

Guo,

Yu,

Huang

2024

Molecular Oral Microbiology

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Breast cancer is among the most prevalent malignancies in women worldwide. Epidemiological findings suggested that periodontal diseases may be associated with breast cancer, among which Fusobacterium nucleatum is considered an important cross‐participant. In this work, we comprehensively summarize the known mechanisms of how F. nucleatum translocates to, colonizes in mammary tumors, and promotes the carcinogenesis. Specifically, F. nucleatum translocates to mammary tissue through the mammary–intestinal axis, direct nipple contact, and hematogenous transmission. Subsequently, F. nucleatum takes advantage of fusobacterium autotransporter protein 2 to colonize breast cancer and uses virulence factors fusobacterium adhesin A and lipopolysaccharide to promote proliferation. Moreover, the upregulated matrix metalloproteinase‐9 induced by F. nucleatum does not only trigger the inflammatory response but also facilitates the tumor‐promoting microenvironment. Aside from the pro‐inflammatory effect, F. nucleatum may also be engaged in tumor immune evasion, which is achieved through the action of virulence factors on immune checkpoint receptors highly expressed on T cells, natural killer cells, and tumor‐infiltrating lymphocytes. Taking breast cancer as an example, more relevant research studies may expand our current knowledge of how oral microbes affect systemic health. Hopefully, exploring these mechanisms in depth could provide new strategies for safer and more effective biologic and targeted therapies targeted at breast cancer.

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“…Simultaneously, the host’s immune system upholds a state of tolerance while curbing immune responses. This is achieved through the actions of mucosal dendritic cells and the release of anti-inflammatory cytokines like IL-10 and prostaglandin E2, the generation of T-regulatory cells also contributes to this process ( Li et al, 2022 ). Consequently, the oral mucosal tissues achieve a harmonious and well-organized stability, balancing the survival needs of various microorganisms ( Sami et al, 2020 ).…”

Section: Carcinogenic Mechanismmentioning

confidence: 99%

Insights into the oral microbiota in human systemic cancers

Su,

Yang,

Sheng

et al. 2024

Front. Microbiol.

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The oral cavity stands as one of the pivotal interfaces facilitating the intricate interaction between the human body and the external environment. The impact of diverse oral microorganisms on the emergence and progression of various systemic cancers, typified by oral cancer, has garnered increasing attention. The potential pathogenicity of oral bacteria, notably the anaerobic Porphyromonas gingivalis and Fusobacterium nucleatum, has been extensively studied and exhibits obvious correlation with different carcinoma types. Furthermore, oral fungi and viruses are closely linked to oropharyngeal carcinoma. Multiple potential mechanisms of oral microbiota-induced carcinogenesis have been investigated, including heightened inflammatory responses, suppression of the host immune system, influence on the tumor microenvironment, anti-apoptotic activity, and promotion of malignant transformation. The disturbance of microbial equilibrium and the migration of oral microbiota play a pivotal role in facilitating oncogenic functions. This review aims to comprehensively outline the pathogenic mechanisms by which oral microbiota participate in carcinogenesis. Additionally, this review delves into their potential applications in cancer prevention, screening, and treatment. It proves to be a valuable resource for researchers investigating the intricate connection between oral microbiota and systemic cancers.

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Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis

Cited by 15 publications

References 154 publications

The role of oral microbiota in cancer

The role of oral microbiota in cancer

The ways Fusobacterium nucleatum translocate to breast tissue and contribute to breast cancer development

Insights into the oral microbiota in human systemic cancers

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