Oral microbiota signatures in post-traumatic stress disorder (PTSD) veterans

Levert-Levitt, Ella; Shapira, Guy; Sragovich, Shlomo; Shomron, Noam; Lam, Jacqueline C. K.; Li, Victor O. K.; Heimesaat, Markus M.; Bereswill, Stefan; Yehuda, Ariel Ben; Sagi‐Schwartz, Abraham; Solomon, Zahava; Gozes, Illana

doi:10.1038/s41380-022-01704-6

Cited by 18 publications

(11 citation statements)

References 53 publications

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“…Many studies have shown that the oral microbiota has a strong connection with neuropsychiatric disorders, such as autism spectrum disorder ( Hicks et al., 2018 ), Alzheimer’s disease ( Ryder, 2020 ) and cognitive decline in elderly individuals ( Vanhatalo et al., 2021 ). The newly discovered bacterial signature could allow for the deployment and stratification of soldiers with posttraumatic stress disorder according to changes in oral microbiota abundance ( Levert-Levitt et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Diurnal changes of the oral microbiome in patients with alcohol dependence

Zhao

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundSaliva secretion and oral microbiota change in rhythm with our biological clock. Dysbiosis of the oral microbiome and alcohol consumption have a two-way interactive impact, but little is known about whether the oral microbiome undergoes diurnal changes in composition and function during the daytime in patients with alcohol dependence (AD).MethodsThe impact of alcohol consumption on the diurnal salivary microbiome was examined in a case-control study of 32 AD patients and 21 healthy control (HC) subjects. We tested the changes in microbial composition and individual taxon abundance by 16S rRNA gene sequencing.ResultsThe present study is the first report showing that alcohol consumption enhanced the richness of the salivary microbiome and lowered the evenness. The composition of the oral microbiota changed significantly in alcohol-dependent patients. Additionally, certain genera were enriched in the AD group, including Actinomyces, Leptotrichia, Sphaerochaeta and Cyanobacteria, all of which have pathogenic effects on the host. There is a correlation between liver enzymes and oral microbiota. KEGG function analysis also showed obvious alterations during the daytime.ConclusionAlcohol drinking influences diurnal changes in the oral microbiota, leading to flora disturbance and related functional impairment. In particular, the diurnal changes of the oral microbiota may open avenues for potential interventions that can relieve the detrimental consequences of AD.

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Section: Introductionmentioning

confidence: 99%

Diurnal changes of the oral microbiome in patients with alcohol dependence

Zhao

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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“… [64] 16 S RNA sequencing of the oral microbiome in Israeli veterans with Post Traumatic Stress Disorder (PTSD) after participating in war A microbiota signature (reduced bacteria such as sp_HMT_914, 332, and 871, and Noxia) correlated with PTSD severity and additional psychopathological symptoms, including anxiety, hostility, memory difficulties, and idiopathic pain. [65] 16 S rRNA gene sequencing between patients of anxiety or depression with low and high symptoms No significant differences in alpha and beta diversity were seen between anxiety or depression groups (high versus low symptoms). Higher Spirochaetes and Spirochaetales in participants with high anxiety or depression symptoms.…”

Section: Psychological Stress and Oral Microbesmentioning

confidence: 89%

“…Various preclinical ( Table 1 ) [60] , [61] and clinical studies ( Table 2 ) [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] have demonstrated the effect of psychological stress on the oral microbiome via alterations in the diversity and taxonomic abundance of the bacteria. The alpha diversity measures the richness or evenness of the species within a sample, which is commonly determined by 16 S rRNA sequencing.…”

Section: Psychological Stress and Oral Microbesmentioning

confidence: 99%

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Paudel

Uehara²,

Giri³

et al. 2022

Japanese Dental Science Review

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“…Using a cohort of Israel veterans from the 1982 Lebanon war, Levert-Levitt et al [ 98 ] found that the oral microbiota signature (specifically, reduced levels of bacteria sp_HMT_914, 332 and 871 , as well as Noxia ) correlated with the severity of post-traumatic stress disorder (PTSD). Conversely, the duration of education was associated with higher levels of sp_HMP_871 and decreased levels of Bacteroides and Firmicutes .…”

Section: Oral Microbiotamentioning

confidence: 99%

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

Hashimoto

2023

Mol Psychiatry

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The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on the potential association between the microbiota and various neuropsychiatric disorders. The microbiota resides in various parts of the body, such as the oral cavity, nasal passages, lungs, gut, skin, bladder, and vagina. The gut microbiota in the gastrointestinal tract has received particular attention due to its high abundance and its potential role in psychiatric and neurodegenerative disorders. However, the microbiota presents in other body tissues, though less abundant, also plays crucial role in immune system and human homeostasis, thus influencing the development and progression of neuropsychiatric disorders. For example, oral microbiota imbalance and associated periodontitis might increase the risk for neuropsychiatric disorders. Additionally, studies using the postmortem brain samples have detected the widespread presence of oral bacteria in the brains of patients with Alzheimer’s disease. This article provides an overview of the emerging role of the host microbiota in neuropsychiatric disorders and discusses future directions, such as underlying biological mechanisms, reliable biomarkers associated with the host microbiota, and microbiota-targeted interventions, for research in this field.

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Oral microbiota signatures in post-traumatic stress disorder (PTSD) veterans

Cited by 18 publications

References 53 publications

Diurnal changes of the oral microbiome in patients with alcohol dependence

Diurnal changes of the oral microbiome in patients with alcohol dependence

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

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