Oral midazolam is a safe and effective premedication in adult outpatients undergoing brachytherapy for cancer cervix under general anaesthesia: A prospective randomised, double blind placebo-controlled study

Bansal, Rakhi; Joad, Anjum Khan; Saxena, Meenakshi; Hemrajani, Manisha

doi:10.4103/0019-5049.160955

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…Most patients with cervical cancer experience negative emotions, such as anxiety and fear, before brachytherapy. Additionally, pain during brachytherapy leads to resistance to or even refusal of subsequent treatment 10,11 . Therefore, developing an ideal analgesic for brachytherapy is important.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, pain during brachytherapy leads to resistance to or even refusal of subsequent treatment. 10,11 Therefore, developing an ideal analgesic for brachytherapy is important. To date, no consensus has been reached on the most effective analgesic modality for brachytherapy, which varies between centers.…”

Section: Discussionmentioning

confidence: 99%

“…The VAS is a well-validated instrument for assessing pain intensity, which is easy to use and preferred by patients, and intensity on a verbal rating scale as mild (1-3), moderate (4-6), severe (7-9), and very severe (10) brachytherapy session, and the higher the total score, the higher the degree of anxiety and depression. 7 The application of the interstitial needle, short-term local efficacy, and patient satisfaction rates were analyzed.…”

Section: Evaluation Parametermentioning

confidence: 99%

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Clinical study of analgesia in brachytherapy for cervical cancer

Liu,

Wu,

et al. 2023

Precision Radiation Oncology

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Objective: This study investigated the analgesic effects in patients with cervical cancer during brachytherapy. Methods:In this prospective study, 100 patients with cervical cancer who were admitted to Chongqing University Cancer Hospital between July 2021 and April 2022 were randomly divided into an analgesia group (n = 50) and a control group (n = 50). The visual analog scale (VAS) scores at applicator placement-T1, CT-scan-T2, and removal -T3, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores before brachytherapy, short-term clinical efficacy, and patient satisfaction were compared between the two groups. Results:The VAS score of the analgesia group was significantly different at T1 (0 vs. 4.34±1.02, t = 67.40, p < 0.001), but not in the control group; however, there was no significant difference between the two groups at T2 (t = -0.49, p = 0.623) and T3 (t = -0.12, p = 0.912). The SAS and SDS scores first decreased and then increased in the analgesic group and increased in the control group with increasing brachytherapy time. Except for the first measurement, the differences between the two groups were statistically significant (all p < 0.001). The application of interstitial implantation (p = 0.027), local efficacy (p = 0.047), and patient satisfaction rates (p = 0.025) were higher in the analgesic group than in the control group. Conclusion:Analgesia can relieve pain, maintain physical and mental health, and improve outcomes and patient satisfaction rates for cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Evaluation Parametermentioning

confidence: 99%

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Clinical study of analgesia in brachytherapy for cervical cancer

Liu,

Wu,

et al. 2023

Precision Radiation Oncology

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“…Naguib and Samarkandi [18] reported that midazolam premedication had an anxiolytic and sedative effect before surgery, and that it increased patient satisfaction. Likewise, Bansal et al [19] stated that midazolam premedication reduces patients’ anxiety and induces sedation before anesthesia induction, but that it does not cause hemodynamic changes before or after anesthesia induction.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trial assessing the effectiveness of midazolam premedication as an anxiolytic, analgesic, sedative, and hemodynamic stabilizer

Jeon

Lee

Do³

et al. 2018

Medicine

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Pain scores reduction with the use of ultrasound-guided paracervical nerve block in patients with cervical cancer undergoing intracavitary brachytherapy: A randomized controlled trial

Rong,

Yang,

Zhang

et al. 2024

PLoS ONE

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Study objective To determine the safety and effectiveness of ultrasound-guided paracervical nerve blocks for the painless treatment of patients with cervical cancer post-implantation. Design Single-center randomized controlled trial. Setting Fourth Hospital of Hebei Medical University (July 2023 to October 2023). Trial number ChiCTR2300071580 [https://clin.larvol.com/trial-detail/ChiCTR2300071580]. Patients Eighty patients with cervical cancer underwent post-implantation treatment. Interventions Patients receiving and not receiving paracervical nerve blocks (Groups T and C, respectively) were randomly allocated. Measurements Primary measures included visual analog scale (VAS) scores and patient body movement scores at various stages, including vaginal speculum placement (T1), applicator/needle insertion (T2), treatment administration following connection of the treatment tube (T3), needle withdrawal and hemostasis (T4), and willingness to receive further treatment. The secondary observation indices in this study included the operation time, incidence of hypoxemia, occurrence of nausea and vomiting, adverse events related to the circulatory system, patient satisfaction score, operator satisfaction score, and operation duration required by patients with an Alderte score of ≥ 9. Main results Forty patients each were randomly allocated into Groups T and C. The VAS scores did not differ significantly between the two groups at T1. However, at T3 and T4, the VAS scores of Group T was significantly lower than that of Group C. No significant difference was observed in the body movement scores between the two groups at T1 and T3. However, the body movement score of Group T was significantly lower than that of Group C (P < 0.001) at T2 and T4. Group T showed higher postoperative satisfaction and willingness to receive further treatment compared to that of Group C. Conclusions Ultrasound-guided paracervical nerve block effectively reduced the pain scores in patients with cervical cancer undergoing post-implantation treatment and enhanced their inclination to undergo further treatment.

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Oral midazolam is a safe and effective premedication in adult outpatients undergoing brachytherapy for cancer cervix under general anaesthesia: A prospective randomised, double blind placebo-controlled study

Cited by 6 publications

References 10 publications

Clinical study of analgesia in brachytherapy for cervical cancer

Clinical study of analgesia in brachytherapy for cervical cancer

Randomized controlled trial assessing the effectiveness of midazolam premedication as an anxiolytic, analgesic, sedative, and hemodynamic stabilizer

Pain scores reduction with the use of ultrasound-guided paracervical nerve block in patients with cervical cancer undergoing intracavitary brachytherapy: A randomized controlled trial

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