2000
DOI: 10.7326/0003-4819-132-2-200001180-00002
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Oral Montelukast Compared with Inhaled Salmeterol To Prevent Exercise-Induced Bronchoconstriction

Abstract: The bronchoprotective effect of montelukast was maintained throughout 8 weeks of study. In contrast, significant loss of bronchoprotection at weeks 4 and 8 was seen with salmeterol. Long-term administration of montelukast provided consistent inhibition of exercise-induced bronchoconstriction at the end of the 8-week dosing interval without tolerance.

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Cited by 186 publications
(90 citation statements)
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“…For those subjects, leukotriene receptor antagonists may be more suitable since they are as effective as long-acting β 2 agonists in this setting (49,65) and do not loose their protective effect when used on a regular basis (63)(64)(65). In addition, the response to rescue short-acting β 2 agonists after exercise is fully maintained during regular treatment with leukotriene receptor antagonists, which may not be true during treatment with regular β 2 agonists (65,66).…”
Section: Cold Air-provoked Short-term Responsesmentioning
confidence: 99%
See 1 more Smart Citation
“…For those subjects, leukotriene receptor antagonists may be more suitable since they are as effective as long-acting β 2 agonists in this setting (49,65) and do not loose their protective effect when used on a regular basis (63)(64)(65). In addition, the response to rescue short-acting β 2 agonists after exercise is fully maintained during regular treatment with leukotriene receptor antagonists, which may not be true during treatment with regular β 2 agonists (65,66).…”
Section: Cold Air-provoked Short-term Responsesmentioning
confidence: 99%
“…As inhaled long-acting β 2 agonists rapidly loose their protective effect on exercise-provoked asthma when used on a regular basis (62)(63)(64), their use may not be advocated in subjects who exercise regularly in cold weather. For those subjects, leukotriene receptor antagonists may be more suitable since they are as effective as long-acting β 2 agonists in this setting (49,65) and do not loose their protective effect when used on a regular basis (63)(64)(65).…”
Section: Cold Air-provoked Short-term Responsesmentioning
confidence: 99%
“…Montelukast reduces the % fall in FEV 1 by 40-60% and reduces the time of recovery of FEV 1 to pre-exercise levels. Furthermore, no tolerance develops to this drug when it is used daily [11]. However, not all subjects have their EIB significantly inhibited by montelukast.…”
Section: Editorialmentioning
confidence: 99%
“…Repeated administration with β2-agonists results in tachyphylaxis, whereas that of LTRA does not. Montelukast persistently prevents EIB even after four and eight weeks of administration, whereas the preventive effects of salmeterol, a LABA, were attenuated [38]. aspirin-intolerant, than tolerant asthma [39].…”
Section: Exercise Induced Bronchoconstriction (Eib)mentioning
confidence: 99%