Oral Mucoadhesive Buccal Film of Ciprofloxacin for Periodontitis: Preparation and Characterization

Wu, Weiping; Chen, Wei; Jin, Qiong

doi:10.4314/tjpr.v15i3.3

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…Other authors have prepared CPX films by the solving casting method but using other polymers and with different therapeutic applications, but few of them have measured the homogeneity in drug content. Wu et al developed mucoadhesive buccal CPX-films for periodontitis, using sodium carboxymethyl cellulose and sodium alginate as polymers, showing good drug loading (94.50 ± 0.04 to 99.69 ± 0.21%), but the authors did not measure drug distribution [ 41 ]. Salguero et al developed hybrid composite films based on layered double hydroxide and hyaluronan to deliver CPX for the prophylaxis and treatment of opportunistic infections in wounds.…”

Section: Resultsmentioning

confidence: 99%

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Guillot

Petalas

Skondra

et al. 2021

Drug Deliv. and Transl. Res.

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Infections of the eye are among the leading causes of vision impairment and vision loss worldwide. The ability of a drug to access the anterior parts of the eye is negligible after systemic administration. Effective drug delivery to the eye is a major challenge due to the presence of protective mechanisms and physiological barriers that result in low ocular availability after topical application. The main purpose of this work was the improvement of the corneal and conjunctival permeation of the antibiotic Ciprofloxacin, a wide spectrum antibiotic used for the most common eye infection, using a self-dissolving polymeric film. Films were prepared by the solvent casting technique, using polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (Soluplus), polyvynyl alcohol, and propylene glycol. Films were homogeneous in drug content and thickness, as demonstrated by adapting the Swiss Roll technique followed by microscopy observation. These films proved in vitro to control the release of the Ciprofloxacin. Ex vivo permeability studies using Franz diffusion cells and porcine cornea and sclera showed an effective permeability of the drug without inducing irritation of the tissues. Films swelled in contact with artificial tears forming an in situ gel over 20 min, which will improve drug contact and reduce the need of multiple dosing. The antibiotic activity was also tested in vitro in five types of bacterial cultures, assuring the pharmacological efficacy of the films. The developed films are a promising drug delivery system to topically treat or prevent ocular infections. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Guillot

Petalas

Skondra

et al. 2021

Drug Deliv. and Transl. Res.

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“…An acidic or alkaline pH may irritate the buccal mucosa and affect the degree of polymer hydration. Therefore, the surface pH of the buccal films were selected to optimise both the mucoadhesion and drug release (Wu, Chen, Jin, 2016). All formulations were dissolved after completely an hour for hydrophilic drug and polymer, ability to swell rapidly ( Table.2d).…”

Section: Resultsmentioning

confidence: 99%

“…Swelling index (SI) was also measured using the same parameters. Swelling index was calculated using following formula (Nair et al, 2013;Perioli et al, 2004;Wu, Chen and Jin, 2016): SI = [Ws -Wd] /Wd × 100; where Wd= Dry weight of buccal film .Ws= Weight of film after swelling.…”

Section: Surface Ph and Swelling Index (Si)mentioning

confidence: 99%

Future drug delivery technologies: benchtop to industry

et al. 2018

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Transmucosal buccal drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for paediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucloxacillin sodium, across the mucosal route. The buccal films are comprised of a bio-adhesive polymer, plasticizer and drug. Optimised films were characterised by measurement of weight, length and width, hardness, thickness, surface pH, moisture content and uptake, swelling study, folding resilience, hydration and entrapment efficiency. Drug release studies were performed for different polymer-plasticizer-drug ratios. Concentration of polymer and plasticizer were influenced on the development, evaluation and release rate of flucloxacillin sodium from the buccal films. In conclusion, these studies reveal that buccal delivery of flucloxacillin sodium can be an alternative route in comparison to conventional route for patient compliance.IIUC Studies Vol.14(1) June 2017: 09-20

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“…Swelling studies of the films were also measured after hour, following same temperature as pH measurement. The equation involved in calculation of swelling is given below: [12][13][14] [ ] Folding endurance of the films was determined manually for films. It was counted when a film folded at a fixed position till it fractures.…”

Section: Methodsmentioning

confidence: 99%

Inkjet printing of doxycycline loaded transdermal film for wound infection

Uddin¹

2018

MOJBB

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Recent developments in inkjet printing technology have an influence on the development of personalised medicine. Inkjet printing is a latest tool for the printing of active pharmaceutical ingredient in precise and accurate manner with minimum material loss. The aim of the study was to develop and characterise the inkjet printer fast dissolving transdermal films for the delivery of a model drug (doxycycline) for wound infection. The formulations were prepared by using mucoadhesive polymer (hydroxypropyl methyl cellulose), cellulose gum (sodium carboxymethyl cellulose)/ instant release film former (Kollicoat®)-a polyvinyl alcohol/polyethylene glycol graft copolymer and plasticiser (glycerol). Preliminary studies were carried out for weight uniformity, percentage moisture content and uptake, folding endurance, elongation, swelling index, surface pH, hydration time and in vitro release studies using modified Franz Diffusion Cells. Concentration of different polymers was tailored by the release rate of doxycycline from the films. In conclusions, inkjet printing can be a key tool for the manufacture of thin films for the treatment a wide range of bacterial wound infection.

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Oral Mucoadhesive Buccal Film of Ciprofloxacin for Periodontitis: Preparation and Characterization

Abstract: Purpose: To prepare and characterise ciprofloxacin mucoadhesive buccal films for localised, improved drug delivery in periodontitis. Methods:Ciprofloxacin-loaded buccal films containing 50 mg ciprofloxacin were prepared mucoadhesive polymers sodium cellulose (SCMC)

Cited by 13 publications

References 19 publications

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Future drug delivery technologies: benchtop to industry

Inkjet printing of doxycycline loaded transdermal film for wound infection

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