Oral Mucocutaneous Diseases

Jaafari‐Ashkavandi, Zohreh; Mardani, Maryam; Pardis, Soheil; Amanpour, Sara

doi:10.1097/scs.0b013e31820fe1f0

Cited by 22 publications

(6 citation statements)

References 20 publications

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“…About half of our patients reported substantial pain or discomfort related to their disease. This finding is in accordance with other studies in which a high proportion of OLP patients were symptomatic (2,28). We observed patients with two or more sites affected by lichen planus and extraoral involvement of lichen planus was seen in approximately one out of five patients.…”

Section: Discussionsupporting

confidence: 93%

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Oral lichen planus: a 4-year clinical follow-up study

Rimkevičius¹,

Aleksejūnienė²,

Pūrienė³

et al. 2017

Turk J Med Sci

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Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors. Materials and methods:All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Histology was used to validate the OLP diagnosis and to evaluate the malignant transformation of OLP lesions. Clinical manifestations of OLP and potential local oral environment-related risks were clinically assessed. Systemic risks were evaluated by a structured questionnaire.Results: A total of 133 patients with a histologically confirmed OLP diagnosis were followed. There were more females (N = 109) than males (N = 24) and the majority of patients were older than 50 years. The reticular form (45.1%) was the most prevalent clinical form followed by the erosive-ulcerative form (33.8%). The histological characteristics were most pronounced in the erosive-ulcerative form. Of the OLP cases, 2.3% had a malignant transformation. Conclusion:Reticular and erosive-ulcerative were the most prevalent OLP forms. There were more female than male OLP patients. Except for medication use, there were no statistically significant differences among different clinical OLP forms in either local or systemic risk factor distributions.

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Section: Discussionsupporting

confidence: 93%

“…The World Health Organization has described oral lichen planus (OLP) as a precancerous disease (1) that may involve the mucous membrane and skin of various areas (2). A predominance of OLP in women, commonly occurring in the 6th and 7th decades of life, has been reported (3,4).…”

Section: Introductionmentioning

confidence: 99%

Oral lichen planus: a 4-year clinical follow-up study

Rimkevičius¹,

Aleksejūnienė²,

Pūrienė³

et al. 2017

Turk J Med Sci

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“…In our meta-analysis we also noted that studies in which patients were followed for longer periods, reported significantly higher rates of malignancy vs. those that followed their patients for shorter periods or did not communicate their follow up periods; it is logical that dysplasia can appear at any time during the evolution of OLP. Some authors continue defending in recent papers ( 20 ) a disease category under the term "lichenoid dysplasia"; Although this creates controversy and disagreement, some positive aspects must also be recognized, such as to reinforce the concept of the potentially malignant nature of OLP. From our point of view, the dysplastic appearance in the context of a lichenoid tissue response has in itself the value in risk prediction indicating or pointing towards an increased risk of oral cancer development in an individual patient.…”

Section: Discussionmentioning

confidence: 99%

Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper

González‐Moles¹,

Warnakulasuriya²,

González‐Ruiz³

et al. 2021

Med Oral

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Background Patients with oral lichen planus (OLP) have an increased risk of oral cancer. For this reason, OLP is classified as an oral potentially malignant disorder. However, the precise personal (or individual) risk is unknown. Recent meta-analytical studies have reported that dysplastic OLP may transform to cancer in around 6% of cases, while the rate of transformation is lower (<1.5%) in non-dysplastic cases. The presence of epithelial dysplasia has emerged as the most powerful indicator for assessing cancer risk in oral potentially malignant disorders in routine practice. However, the general acceptance of epithelial dysplasia as an accompanying histologic feature in OLP is subject to great controversy. Many pathologists consider the presence of dysplasia as a criterion to exclude OLP when routinely reporting on this disease. This practice, widespread among oral pathology professionals, has resulted in the underestimation of the potential for malignancy of OLP. Material and Methods A review of the literature was carried out in order to critically analyze the relevance, controversies and challenges encountered across the diagnosis of epithelial dysplasia in OLP. Results 12 studies have been published examining dysplastic changes in OLP, reporting Figures ranging from 0.54% to 25% of cases with dysplasia in the first diagnostic biopsy. The diagnosis of dysplasia in the OLP poses an additional difficulty due to the fact that the affected oral epithelium per se develops changes related to autoimmune aggression. Among the most frequent histological features of OLP that develops dysplasia are basal cell hyperplasia with basaloid appearance, loss of basal cells polarity, cellular and nuclear pleomorphism and irregular stratification. Conclusions Epithelial dysplasia should not be considered an exclusion criterion for OLP; its evaluation requires experienced pathologists in this field. Key words: Oral lichen planus, epithelial dysplasia, oral cancer.

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“…PV is one of the most common VBDs, which includes a group of autoimmune diseases that are potentially life-threatening and cause blisters and erosions on the skin and mucous membranes [4,5]. Pemphigus vulgaris oral lesions may present several months before skin lesions in more than half of the patients [6].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic Study of Patients with Chronic Vesiculobullous Lesions

Lavaee

Vahdatifar²,

Afroozi³

et al. 2022

J Res Dent Maxillofac Sci

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Background and Aim: Vesiculobullous diseases (VBDs) are characterized by the formation of vesicles or bullae. The aim of this study was to perform an epidemiological survey on patients with chronic VBDs referred to Shiraz Dental School during 2006-2016. Materials and Methods: In this retrospective cross-sectional study, epidemiological data (age, sex, prevalence, involvement location, prescribed medication, and underlying diseases) of patients diagnosed with VBDs were collected. The relationship between the epidemiological factors and the occurrence of VBDs was analyzed. SPSS version 18 was used to analyze the data by the Chi-square test and Spearman's correlation test.Results: Totally, 120 patients were evaluated; out of which, 88.3% had pemphigus vulgaris (PV), 4.2% had bullous pemphigoid (BP), 6.8% had mucous membrane pemphigoid (MMP), and 0.1% had pemphigus herpetiformis (PH). Most patients were females (68.3%) and 31.7% were males. The mean age of patients was 43.14±11.41 years. The mucosal and cutaneous involvement in PV patients was as follows: 31.13% had mucosal, 0.94% had cutaneous, 37.73% had both mucosal and cutaneous, and 30.18% had mucosal-cutaneous involvement associated with involvement of other organs. Prednisolone was the first-line treatment in all patients. There was a significant correlation between age and incidence of VBDs in patients (P=0.030). Conclusion: Our findings indicated that the epidemiological properties of VBDs in our study were similar to those in other countries. However, PV was the most common VBD followed by BP.

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Oral Mucocutaneous Diseases

Cited by 22 publications

References 20 publications

Oral lichen planus: a 4-year clinical follow-up study

Oral lichen planus: a 4-year clinical follow-up study

Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper

Epidemiologic Study of Patients with Chronic Vesiculobullous Lesions

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