Oral mucosa and lung cancer: Are genetic changes in the oral epithelium associated with lung cancer?

Abstract

A higher proportion of individuals with lung cancer demonstrate genetic damage to oral mucosa compared to those without cancer.

Lung cancer increases H2O2 concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa

“…Despite has been huge described scientific progress in oncology, cancer therapy is still hindered by the absence of reliable early diagnosis methods (Missel et al, 2015;Fitch, 2019;Behrend et al, 2003). Over the last decade, considerable progress has been achieved in cancer screening using different kinds of markers, such as genetic and epigenetic changes in nuclear DNA (Komerik et al, 2017) and quantitative changes in circulating RNAs (Di et al, 2019). However, these screening methods have certain disadvantages, such as invasiveness, high cost, and difficulties in the result interpretation related to the complexity of nuclear genome (Yu, 2011).…”