Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review

Santana, Lucas Alves da Mota; Vieira, Walbert de Andrade; Gonçalo, Rani Iani Costa; Santos, Marilene; Takeshita, Wilton Mitsunari; Miguita, Lucyene

doi:10.1016/j.jormas.2022.05.005

Cited by 8 publications

(12 citation statements)

References 40 publications

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“… [ 18 ] Systematic review The ulcerated oral lesions may have relationship with mild to moderate symptoms for COVID-19 or had acute COVID-19. [ 29 ] Systematic review The effect on oral mucosa is unclear [ 24 ] Systematic review Oral manifestations in SARS-CoV-2 infection cannot be clearly established due to the possible association of other factors, eg, individual or environmental factors. [ 16 ] Systematic review A wide variety of orofacial mucocutaneous lesions manifest in COVID-19 likely to be secondary to the disease-associated immune impairment and/or pharmaco-therapy rather than a direct result of SARS-CoV-2 infection [ 28 ] Systematic review Clinical evidence-based studies are required to investigate the actual prevalence and possible correlation between COVID-19 and jaw-related disorders.…”

Section: Resultsmentioning

confidence: 99%

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

Sarasati¹,

Agustina²,

Surboyo³

2023

IDR

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Objective Many previously reported publications mentioned that oral lesion in COVID-19 patients was varied. The term oral manifestations refer to pathognomonic features that are found consistently with a specific cause and effect. In this context, the oral manifestation of COVID-19 was inconclusive. This systematic review aimed to analyse previously reported publications related to oral lesions in COVID-19 patients to define as oral manifestations or not. The PRISMA guidelines were implemented in this review. Methods All umbrella reviews, systematic reviews, systematic reviews and meta-analyses, comprehensive reviews, and original and non-original studies were included. Twenty-one of systematic review, 32 original studies and 68 non-original studies reported the oral lesion in COVID-19 patients. Results Most of the publications mentioned that ulcers, macular, pseudomembranes and crusts were frequent oral lesions. The reported oral lesions in COVID-19 patients did not show any pathognomonic features and might be unrelated directly to COVID-19 infections, however, more likely due to gender, age, underlying diseases, and medication. Conclusion The oral lesions found in previous studies do not have pathognomonic features and are inconsistent. Therefore, the reported oral lesion, in present time, cannot be defined as an oral manifestation.

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Section: Resultsmentioning

confidence: 99%

The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

Sarasati¹,

Agustina²,

Surboyo³

2023

IDR

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“…Our findings are in agreement with Lucas Alves da Mota Santana et al, who also reported no sex or age predilection and the oral lesions presented mostly on tongue, lips and palate like our cases with their main clinical presentation being ulcerations. The main causative factor they mentioned was based on a probable hypothesis that covid-19 has a capacity of reactivating viruses like the HSV family [12].…”

Section: Discussionmentioning

confidence: 99%

Do COVID-19 patients receiving hospital care in the ICU develop oral complications? A case series study

Flora¹,

Angeliki²,

Eleana³

et al. 2022

JIH

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Introduction:Following the global pandemic of coronavirus since 2019, oral lesions have been observed in infected patients. There is no clear answer about whether lesions are due to the virus itself or due to secondary manifestations from the patient's comorbidities.Objective: This article aims to report some unique data since there is limited information regarding intubation in the ICU, coronavirus, and oral lesions. Materials and Methods:Here we present oral complications developed in nine Covid-19 patients receiving hospital care in our ICU department in Athens, Greece. The oral findings of the patients were recorded by the doctors in charge of the department in the AsklepieionVoulas' general hospital. Results:The main symptoms of the patients were hairy tongue, coated tongue, candidiasis, and cheilitis. Some other reported lesions were ulcers, gingivitis, atrophic tongue, and leukoplakia. All nine patients (except one) were taking anticoagulants, corticosteroids, and antibiotics intubated with an orotracheal tube. One of the patients was intubated with a nasotracheal tube. The prolonged mechanical ventilation devices and the immunosuppression state of the patients were the primary causative factors for the recorded oral complications. Conclusion:The present case reports highlight the importance of routine oral examination in all infected patients to improve oral health and prevent any further general complications.

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“…Letter to the Editor, During the COVID-19 crisis, several cases of oral and cutaneous lesions were reported by different authors. 1,2 Despite a vast literature being produced in the last years since the outbreak, the disease pathogenesis remains complex up until this day. The emergence of variants of interest (VOCs) of the novel coronavirus such as the Omicron variant (B.1.1.529) and its respective lineages may also represent a challenge to vaccine-induced immunity.…”

Section: Sars-cov-2 Is Capable Of Reactivating Orocutaneous Opportuni...mentioning

confidence: 99%

“…Lucas Alves da Mota Santana 1 Daniel Pitanga de Sousa Nogueira 2 Estela Moura Lima 2 Carlos Eduardo Mendonça Moura Costa 2 Eduardo Morato de Oliveira 3 Breno Ferreira Barbosa 1 Sara Juliana de Abreu de Vasconcellos 2 Cleverson Luciano Trento 1 Wilton Mitsunari Takeshita…”

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