Oral mucosal changes in women with genital HPV infection

Abstract

Sixty different types of human papillomavirus (HPV) are currently recognized. Of these, HPV types 1, 2, 4, 6, 7, 11, 13, 16, 18, 30, 32 and 57 have been identified in oral squamous cell lesions. The prevalence and incidence of clinical HPV infections of oral mucosa are incompletely established, and the figures on subclinical and latent infections are completely lacking. Similarly, no data exist on transmission of oral HPV infections. A long-term prospective follow-up study was started to assess the oral mucosal changes related to HPV infection in women with genital HPV infections. The aim was to elucidate whether genital HPV infections predispose the oral mucosa to this virus. This study reports the clinical, histologic and cytologic findings of oral mucosa as related to the genital status of 334 women prospectively followed-up in Kuopio University Central Hospital since 1981. At the time of examination, 5% presented with hand warts. Clinical wart in oral cavity was found in three patients (0.9%) only. Oral mucosa was clinically normal in 207 of 334 (62%) patients examined. Biopsies (n = 255) were taken from the buccal mucosa beneath the linea alba and above the sulcus in the region of the first molar, or from a lesion whenever present. Cytologic scrapings were taken from both sides of the buccal mucosa. Koilocytes were found in 0.9% of the cytologic scrapings, and in 9.4% of the biopsies. Altogether, four squamous cell papillomas and five flat condylomas were found in the biopsies. Morphologic changes suggestive for HPV were present in 25 biopsies. Hyperkeratosis proved to be a frequent finding (34%) in these biopsies.(ABSTRACT TRUNCATED AT 250 WORDS)

HPV Infections in Heterosexual Couples: Mechanisms and Covariates of Virus Transmission

“…Vaginal discharge may spread to the perineum. HPV infection can also be transmitted via manual-to-genital or oral-to-genital routes (heteroinoculation) [45]. However, so far, factors possibly related to auto-/heteroinoculation such as masturbation, fingernail biting, and current genital warts have not been found to be risk factors for HPV infection [46].…”

Human Papillomavirus in the Oral Cavity

“…Seventeen mucosal HPV types (HPV 6,11,13,16,18,30,31,32,33,35,45,52,55,59,69, 72 and 73) were identified from a variety of oral lesions including oral wart, oral papilloma, oral condylomata, laryngeal papilloma, FEH and squamous cell carcinoma seen in Table 1 (b) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Laryngeal papilloma are exclusively confined to HPV 6 and 11 and FEH exclusively in HPV 13 and 32, respectively (16,21,24).…”

“…In oral cancer specimens, HPV 11, 16, 18, 31, 33 and 35 were revealed from oral malignant and pre-malignant lesions (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, since it is clear that HPV infection of the normal oral cavity is common, the pathogenetic roles of HPV in cancer of the oral cavity remain unclear and are limited (63)(64)(65)(66)(67)(68).…”

“…Benign oral lesions were found associated with HPV 6,11,30, 45 and 55. However, HPV 30,45,52 and 55 were found in rather rare cases of squamous papilloma and verruca vulgaris (16)(17)(18)(19)(20)(23)(24)(25)(26). HPV 13,32,59,69, 72 and 73 were found in oral wart in the HIVinfected patients (15,27).…”

Prevalência de achados sugestivos de papilomavírus humano (HPV) em biópsias de carcinoma espinocelular de cavidade oral e orofaringe: estudo preliminar

“…Seventy types of HPV 3 have been identified so far and were classified according to its distribution on nucleic acids in the viral genome. The subtypes found in the oral cavity were 1, 2, 4, 6, 11, 13, 16, 18, 30, 31, 32 and 57 4 .…”