Highlights
Multiple primary malignancies can occur and could be classified into Synchronous and Metachronous.
Synchronous occurrence of oral malignant melanoma and Dermatofibrosarcoma protuberans is rare with paucity of data on it in the literature.
These lesions can be treated successfully with surgery alone or in combination with chemo-radiotherapy.
The role of general system examination for oral and maxillofacial surgery patients cannot be overemphasized.