Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

Lessa, Roberta Cardim; Alves, Fábio de Abreu; Fortunati, Erika; Lu, Jun

doi:10.3390/biomedicines9111531

Cited by 8 publications

(8 citation statements)

References 75 publications

(110 reference statements)

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“…Previous studies revealed that both DHA and EPA affect CASP3 and, consequently induction of apoptosis (Sauer et al, 2005;Xue et al, 2017). Also, the BCL-2 family proteins are essential in Omega-3-induced cell death (Çetin et al, 2021;Lessa et al, 2021;Ma et al, 2021) suppressed by the L. plantarum. Also, the mRNA level of the BAX gene was upregulated, while BCL-2 was downregulated in C26 cells after being treated with either suspension of L. plantarum or bacteria extract.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies revealed that both DHA and EPA affect CASP3 and, consequently induction of apoptosis (Sauer et al, 2005 ; Xue et al, 2017 ). Also, the BCL‐2 family proteins are essential in Omega‐3‐induced cell death (Çetin et al, 2021 ; Lessa et al, 2021 ; Ma et al, 2021 ). Our findings are in line with those of previous studies.…”

Section: Discussionmentioning

confidence: 99%

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The combined effect of fish oil containing Omega‐3 fatty acids and Lactobacillus plantarum on colorectal cancer

Sharifi

Yazdani

Najafi

et al. 2022

Food Science & Nutrition

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Colorectal cancer (CRC) is one of the deadliest malignancies. Recent attempts have indicated the role of diet in the etiology of CRC. Natural dietary compounds such as probiotics and Omega‐3 fatty acids that act synergistically can be beneficial in finding a tremendous solution against CRC. To date, the combined effect of fish oil containing Omega‐3 fatty acids (Omega‐3) and Lactobacillus plantarum (L. plantarum) on CRC has been left behind. We here evaluated the effects of co‐encapsulation of Omega‐3 and probiotic bacteria on CRC cell lines compared to normal cells. Omega‐3 and L. plantarum bacteria were co‐encapsulated in three ways, including gelatin–gum Arabic, gelatin–chitosan, and chitosan–gum Arabic complex coacervate microcapsules. After treatment of cells (Normal [L929] and colorectal [C26]) by L. plantarum, Omega‐3, and microcapsules, viability and growth capacity of cell lines were measured using the MTT (3‐[4, 5‐dimethylthiazol‐2‐yl]‐2, 5‐diphenyltetrazolium bromide) assay. Isolated total RNA was used to evaluate the expression profile of BCL2‐associated X protein (BAX), B‐cell lymphoma 2 (BCL‐2), and Caspase‐3 (CASP3) genes by real‐time polymerase chain reaction (PCR). Statistical analysis was performed with SPSS 25 software. A value of p < .05 was considered statistically significant. The results indicated a significant reduction in cell viability of C26 in a concentration‐dependent manner in the treated cells with all treatments, except gelatin–gum Arabic microcapsules. The messenger RNA (mRNA) expression level of the BAX and CASP3 genes in C26 cells being treated with all treatments significantly increased than in untreated cells, and the expression level of the anti‐apoptotic factor of the BCL‐2 gene decreased in C26 cells simultaneously (p < .05). Although, the combined effect of Omega‐3 and L. plantarum and microcapsulated treatments had no more effect on viability and apoptosis gene expression of cancer cells compared to Omega‐3 or L. plantarum. In conclusion, combination therapy with fish oil containing Omega‐3 and L. plantarum does not improve the anticancer effect of each alone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The combined effect of fish oil containing Omega‐3 fatty acids and Lactobacillus plantarum on colorectal cancer

Sharifi

Yazdani

Najafi

et al. 2022

Food Science & Nutrition

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“…In the past few decades, Omega-3 PUFAs health benefits have been outlined and escalated in multidisciplinary systemic diseases such as diabetes, cardiovascular diseases and cancer (8,9). They have also been shown to play critical roles in tissue homeostasis restoration and inflammation mitigation in a variety of oral diseases, that include oral mucositis (34). Thus, the main objective of this study was to evaluate the effect of Omega-3 topical emulgel on RIOM prevention in HNC patients treated by radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of topical Omega-3 emulgel in preventing radiation-induced oral mucositis: A randomized clinical trial

Morsy,

El Domiaty,

Meheissen

et al. 2024

Alexandria Dental Journal

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INTRODUCTION:One of the most common debilitating side effects that head and neck cancer patients suffer from during radiation therapy is oral mucositis. This leads to severe oral mucosal inflammation and ulceration that hinder the patient's nutrition and affects his quality of life and overall survival. Recently, Omega-3 polyunsaturated fatty acids have captured special interest in managing oral diseases due to its superior anti-oxidant, anti-inflammatory and wound healing properties. OBJECTIVES:The purpose of this study is to assess the efficacy of topical Omega-3 emulgel in prevention of radiation induced oral mucositis and its associated pain. METHODOLOGY: This study was conducted on thirty-six head and neck cancer patients who were planned to receive radiotherapy. Patients were randomly divided into two groups: Group I: eighteen patients were given conventional preventive treatment and Group II: eighteen patients received topical Omega-3 emulgel. All patients were clinically evaluated at baseline and after three and six weeks from treatment using World Health Organization (WHO) grading system for oral mucositis severity and Visual Analogue Scale (VAS) for perceived pain severity. RESULTS: There was a significant lowering of VAS scores as well as WHO mucositis grades after six weeks of treatment in test group treated with topical Omega-3 emulgel when compared to the control group receiving conventional preventive treatment. CONCLUSIONS: Topical Omega-3 emulgel showed a promising beneficial effect in preventing radiation-induced oral mucositis and reducing its associated pain SHORT RUNNING TITLE: Omega-3 efficacy in oral mucositis prevention

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“…Omega-3 polyunsaturated fatty acids (PUFAs) are recognised as immunonutrients with diverse biological effects, including roles in cell signalling, cell membrane structure, inflammation resolution, and acting on G protein-coupled receptors [83]. While commonly used in the nutritional therapy of cancer patients, the 2017 European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines primarily focus on omega-3 PUFAs for treating cancer-related cachexia, overlooking their potential benefits for managing other cancer-related complications such as anorexia, pain, depression, paraneoplastic syndromes, and mucositis [83,84].…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

Nutrigenomics and Integrative Medicine: Shaping the Future of Cancer Management

Cardim Lessa,

Alves

2024

Molecular Diagnostics of Cancer [Working Title]

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Studies have shown that the treatment incidence of onset cancers significantly rose worldwide after the 90s decade. Multidisciplinary cancer care teams are challenged to keep a survivor’s group’s physical and psychological well-being that presents a long-life perspective. In this way, there is a rise in the search for integrative medicine as complementary or alternative cancer treatments. Although the general information around these subjects is plentiful and diverse, scientific literature still explores the evidence for establishing the possible benefits of nutraceuticals’ bioactive molecules as cancer alternative interventions. Usually, complementary therapy is used to relieve the treatment’s side effects in cancer patients. In addition to conventional treatment, mind-body interventions support patients’ spiritual, emotional, and mental health. Over the last few years, there have been a growing number of studies with significant results on natural products that protect against oral mucositis progression. This narrative review surveys what is known about global patient healthcare as an integrative part of oncologic therapy. The goal is to elucidate the importance of supporting patients and families through complementary therapy with conventional cancer treatments. As a result, these strategies are to soften the impact of the side effects, improve well-being and strengthen the psychological outlook. Ultimately, clinicians and patients must work together to select the best treatment options based on each case’s benefits.

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Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

Cited by 8 publications

References 75 publications

The combined effect of fish oil containing Omega‐3 fatty acids and Lactobacillus plantarum on colorectal cancer

The combined effect of fish oil containing Omega‐3 fatty acids and Lactobacillus plantarum on colorectal cancer

Efficacy of topical Omega-3 emulgel in preventing radiation-induced oral mucositis: A randomized clinical trial

Nutrigenomics and Integrative Medicine: Shaping the Future of Cancer Management

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