Oral mucositis in cancer treatment: Natural history, prevention and treatment

Campos, Maria Inês da Cruz; Campos, Celso Neiva; Aarestrup, Fernando Monteiro; Aarestrup, Beatriz Julião Vieira

doi:10.3892/mco.2014.253

Cited by 108 publications

(102 citation statements)

References 24 publications

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“…The results on mucositis in this study are compared to several studies marked by MASCC/ISOO [7,9]. The number of patients without or with mucositis and mucositis grade I presented in this study (±70%) agree with other results described in the literature [3,25,26]. The green propolis has in its chemical constitution various flavonoids such as galangin and artepillin C, characterizing this compound as anti-inflammatory, antimicrobial and antioxidant [27,28].…”

Section: Discussionsupporting

confidence: 78%

Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Vras¹,

En²,

Fpcl³

et al. 2017

Cancer Rep Rev

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Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions and is caused by radiation dispensed in the treatment of malignant tumors of the head and neck. Propolis shows several biological activities such as antimicrobial and anti-inflammatory properties. These biological activities should prevent a mucositis. The aim is to verify the effectiveness of Brazilian green propolis in a mucoadhesive gel, alcohol free, in preventing oral mucositis in patients that underwent radiotherapy. This research is characterized as a preliminary study with a mean duration of 12 weeks of patients' follow-up in two groups. The selection of participant's groups was randomized. The 26 selected patients were distributed between two groups, 13 in the benzydamine group and 13 in the propolis group. Patients were assessed on an average of 4.5 times totaling 116 diagnoses of mucositis. The percentage of patients who had mucositis greater or equal to 2 in this study was 30.6% for the benzydamine group and 29.6% for propolis gel. For these patients, the propolis gel shows a better performance in maintaining lower rates/grades and recovery of patients from the 17 th session of radiotherapy. This work shows a great possibility of further study in Phase III due to its good results and acceptance with patients.

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Section: Discussionsupporting

confidence: 78%

Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Vras¹,

En²,

Fpcl³

et al. 2017

Cancer Rep Rev

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“…Наиболее распространенный побочный эффект, воз никающий в ходе ЛТ у больных орофарингеальным раком, -лучевой мукозит (эпителиит), возникающий более чем у 60 % пациентов при проведении стандартно-го режима фракционирования и практически у 100 % больных при нетрадиционных режимах или химиолу-чевой терапии [22,23,35]. Зарубежные радиотерапевты отмечают, что более чем в 40 % при проведении об-лучения с лекарственной модификацией развиваются побочные эффекты тяжелой степени [5,7,[17][18][19]27].…”

Section: рис 1 риск возникновения побочных эффектовunclassified

“…1). Так, к факторам риска раннего возникновения и развития тяжелых побочных эффектов можно отнести истоще-ние и тяжелое психологическое состояние больного, пожилой возраст, сопутствующие заболевания, травмы слизистых полости рта и глотки, наличие кариозных зубов, выраженный болевой синдром, курение и прием алкоголя [21][22][23][24]. Исключение влияния этих факторов настолько важно, что участие профильных специали-стов в составе мультидисциплинарной команды и объ-ем сопроводительной терапии указывается в рекомен-дациях как обязательные для успешного лечения опухолей головы и шеи [25].…”

Section: Introductionunclassified

Basic principles of managing radiation and drug induced mucositis and dermatitis for oropharyngeal squamouscell carcinoma

Gevorkov¹,

Бойко²,

Болотина³

et al. 2016

Opuholi golovy šei

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Опухоли ГОЛОВЫ и ШЕИ HEAD and NECK tumors Том 6 Vol. 6 3'2016 Диагностика и лечение опухолей головы и шеи 12Основные принципы ведения пациентов с мукозитом и дерматитом при лучевом лечении с лекарственной модификацией больных плоскоклеточным раком орофарингеальной области

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“…These effects may be acute, occurring during the treatment or subsequent weeks, or chronic, detected months or years after RT [10][11] . In general, mucositis generally is most frequent complaint 12 .…”

Section: Introductionmentioning

confidence: 99%

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Jardim¹,

Cunha-Correia²,

Okamoto³

et al. 2017

Arch Health Invest

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Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review AbstractThe occurrence and severity of mucositis are the main complaints of patients with head and neck cancer submitted to radiotherapy (RT). This condition appears to be associated with changes in the oral microbiota and other side effects of RT, such as xerostomia and candidiasis. The aim of this study was to evaluate the effect of RT on the oral microbiota and its impact on radioinduced mucositis through literature review. Descriptors were selected for the collection of information in different databases, especially SciELO, BIREME, LILACS and PubMed. It was decided to consider only articles published since 1985. The descriptors radiotherapy, mucositis, dental caries, xerostomia, head and neck neoplasms and health promotion were used. It was selected 91 articles specifically discussing the microbiological aspects of mucositis, dental caries, oral candidiasis and microbial effects on the oral health of cancer patients, and 59 were included in the review. It was observed that microbial contamination is a secondary phenomenon capable of exacerbate the inflammation induced by the interaction of the radiation with the oral tissues, aggravating mucositis mainly in patients who present precarious conditions of oral hygiene, which reinforces the role of preventive dentistry in the follow up of the irradiated patient. Descriptors: Radiotherapy; Mucositis; Dental Caries; Xerostomia; Head And Neck Neoplasms; Health Promotion. ResumoA ocorrência e a severidade da mucosite constituem as principais queixas dos pacientes com câncer de cabeça e pescoço submetidos à radioterapia (RT). Essa condição parece estar associada às modificações da microbiota bucal e aos demais efeitos colaterais da RT, como xerostomia e a candidíase. O presente trabalho de revisão da literatura teve como objetivo avaliar o efeito que a RT exerce sobre a microbiota bucal e seu impacto na mucosite radioinduzida através de revisão de literatura. Foram selecionados os descritores para a coleta de informações em diferentes bancos de dados, destacando-se SciELO, BIREME, LILACS e PubMed. Decidiu-se considerar apenas artigos publicados desde 1985. Utilizou-se como descritores os termos radioterapia, mucosite, cárie dentária, xerostomia, neoplasias de cabeça e pescoço e promoção da saúde. Foram selecionados 91 artigos que discutiam especificamente os aspectos microbiológicos da mucosite, cárie dentária, candidíase oral e efeitos microbianos na saúde bucal de pacientes oncológicos e 59 foram incluídos na revisão. Observou-se que a contaminação microbiana é fenômeno secundário capaz de agravar a inflamação induzida pela interação da radiação com os tecidos bucais, agravando-se, principalmente, em pacientes que apresentam condições precárias de higiene bucal, o que reforça o papel da odontologia preventiva no acompanhamento do paciente irradiado. Descritores: Radioterapia; Mucosite; Cárie Dentária; Xerostomia; Neoplasias de Cabeça e Pescoço; Promoção da...

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Oral mucositis in cancer treatment: Natural history, prevention and treatment

Cited by 108 publications

References 24 publications

Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Basic principles of managing radiation and drug induced mucositis and dermatitis for oropharyngeal squamouscell carcinoma

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

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