Oral Mucositis in Children Suffering from Acute Lymphoblastic Leukaemia”

Abstract

Background: Oral mucositis is the most commonly reported side effect observed in neoplastic patients treated with chemotherapy and radiotherapy of the head and neck region as well as in patients who have received a haematopoietic stem cell transplant. The aim of the study was to assess the oral mucosa status in children with acute lymphoblastic leukaemia (ALL) during antineoplastic therapy. Material and methods:The clinical examination included 127 children aged 5-15 with ALL. The clinical examination was conducted using the dental diagnostic instrument. The condition of the oral mucosa was determined using the WHO scale for oral mucositis. Results: In the first period of antineoplastic therapy the pathological lesions of the oral mucosa of the mucositis type were observed among the examined patients. The lesions had various levels of intensity. Pain was found to be the primary symptom of oral mucositis. In this study the following were observed: local erythema of the oral mucosa in 10%, ulcerative lesions in 5%.The remaining 85% patient who could not eat or drink because of pain and soreness. Conclusion: Local treatment of oral mucositis with polyantibiotic-antifungal mixture, supporting antifungal systemic treatment, and improving the overall peripheral blood conditions in children suffering from acute lymphoblastic leukaemia improve the condition of the oral mucosa.

Association of GATA3 Rs3824662 Gene Polymorphism with Response to Induction Therapy in Acute Lymphoblastic Leukemia

“…In the pediatric group, the male gender was observed more than females and this is in agreement with Iraqi studies by Al-Hadad et al (23) , Shalal et al (26) , Mustafa et al (27) , and Alani et al (28) as well as other studies by Liu et al (17) , Mosaad et al (19) , Hussein et al (24) , and Ali et al (25) .…”

“…Bleeding tendency and splenomegaly were the most common presenting complaints in the pediatric group included and this following the Eygptian study by Mosaad et al (19) , but was different from the result of the Iraqi study by Shalal et al (26) who reported that most frequent symptoms were fever and pallor and another Iraqi study by Alani, (28) which show that swollen lymph node was the most presenting symptom.…”

Evaluation of oral mucositis in pediatric cancer patients in Hiwa Hospital in Sulaymaniyah city, Kurdistan Region, Iraq

“…Another proposed mechanism is that repair of the mucosa is accelerated with the recovery of white cells and neutrophil counts. 12 The present study found no association between platelet counts and oral mucositis. This disagrees with the results of Mendonça et al from Brazil and Ye et al from Sweden, who found a highly significant association.…”

“…9 However, according to Devaraju et al from India, the leukocyte levels below 2,500/μL increase the risk of oral mucositis. 10 The probable reason for the finding of 5,[11][12][13] The possible factors for the link between ANC count and severity of oral mucositis rose from the topical and systemic GM-CSF treatment that reduced duration and severity of oral mucositis by recovering neutrophil counts. 11 Predisposition to mucositis is high in patients with low neutrophil counts (<500 cell/μL) because the incidence of microbial infection increased.…”