Oral multiunit pellet extended release dosage form: A review

Abstract

Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving extended release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from pellets depends on a variety of factors including the carrier used to form pellets and the amount of drug contained in them. Consequently, pellets provide tremendous opportunities for designing new controlled and extended release oral formulations, thus extending the frontier of future pharmaceutical development.DOI: http://dx.doi.org/10.3329/icpj.v2i10.16413 International Current Pharmaceutical Journal, September 2013, 2(10): 177-184

Application of design mixture and desirability function in the optimization of pharmaco-technical parameters of macrogols-based suppositories

“…The modern pharmaceutical industry has different routes of administration and pharmaceutical forms in order to deliver the active ingredients to the site of action (Ummadi, 2013;Shargel et al, 2015;Loyd et al, 2013;Yvonne and V'iain, 2015). Among these routes, the oral route is the most commonly used, with the use of tablet and capsule forms in particular (Shargel et al, 2015;Loyd et al, 2013;Sachdeva et al, 2013). Next to it are the topical, parenteral, and rectal pathways (Yvonne and V'iain, 2015;Sachdeva et al, 2013).…”

“…Among these routes, the oral route is the most commonly used, with the use of tablet and capsule forms in particular (Shargel et al, 2015;Loyd et al, 2013;Sachdeva et al, 2013). Next to it are the topical, parenteral, and rectal pathways (Yvonne and V'iain, 2015;Sachdeva et al, 2013). The latter is one of the oldest routes of administration (Shargel et al, 2015;Loyd et al, 2013;Touitou and Barry, 2006) and can be considered a good alternative to the oral route for children in an emergency with loss of consciousness, elderly subjects and in case of vomiting (Yvonne and V'iain, 2015;Jannin et al, 2014).…”

Development and radiographical evaluation of floating tablets with combination of Amoxicillin Trihydrate and Ranitidine Hydrochloride

“…However, the developed conventional oral dosage forms have many pitfalls because of its overdose due to multiple times administration of dosage form to a patient this disadvantage was overcome by developing the extended-release formulations (AAH Abdellatif, 2018) like sustained oral release and controlled release formulations. These formulations optimize the biopharmaceutical, pharmacokinetic and pharmacodynamic properties (Mayur Karvekar et al, 2017) of active pharmaceutical ingredient in such a way decreases the frequency (Vishal Sachdeva et al, 2013) of dosing to © Pharmascope Publications | International Journal of Research in Pharmaceutical Sciences an extent to that of daily once administration of dosage form is sufficient to maintain the drug levels in therapeutic window.…”