Oral N-Acetyl Cysteine Lowered IL 6 Level Among Stage V Chronic Kidney Disease Patients on Continuous Ambulatory Peritoneal Dialysis (CAPD)

Abstract

(8,13 + 7,62 vs 11,16 + 8,32, p = 0,001), secara signifikan (p <0,001). Kadar IL 6 sebelum dan sesudah pengobatan pada kelompok perlakuan adalah (9,72 + 7,29 vs 6,09 + 3,82, p = 0,002); Menurun secara signifikan (p <0,05). Kesimpulan: Oral NAC menurunkan kadar IL 6 pada pasien CKD stadium V yang menjalani CAPD.Background: IL 6 level is increased in stage V CKD patients on CAPD. N-Acetyl Cysteine is a compound containing thiol with antioxidant and anti-inflammatory effects. Objective: To examine the effect of oral NAC on IL 6 level in stage V CKD patients on CAPD. Methods: An experimental research with Randomized Double Blind Control Trial, involving 30 CKD patients on CAPD in Dr Moewardi Hospital. They were divided into control group/placebo (15 patients) and oral NAS treatment group (15 patients). IL 6 level was measured before and after 8 weeks of treatment. Results : Level of IL 6 before and after treatment in control group were (8.13 + 7.62 vs 11.16 + 8.32 , p= 0,001), significantly (p<0,001). Level of IL 6 before and after treatment in treatment group were (9.72 + 7.29 vs 6.09 + 3.82, p = 0,002); lowered significantly (p<0,05). Conclusion: Oral NAC lowered the level of IL 6 in stage V CKD patients on CAPD.