Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

Chen, Cheng; Beloqui, Ana; Xu, Yining

doi:10.1016/j.addr.2023.115117

Cited by 12 publications

(2 citation statements)

References 307 publications

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“…Because of this, there should be careful consideration given to the chance that they could injure many target organs as well as the circulation system by passing via the digestive tract (Medina-Ramirez et al 2023). Various research data has indicated that ingested nanoparticles are rapidly removed from the intestinal system as a result of the epithelium's ongoing renewal (Chen et al 2023;Kim et al 2023), while numerous other studies provide unambiguous proof of specific NPs being translocated to target organs (Bongaerts et al 2020;de Almeida et al 2021). It has been discovered recently that, in comparison of different copper particles, oral ingestion of copper NPs can cause serious harm to the kidney, liver, and spleen of rodents (Tang et al 2018).…”

Section: Ingestionmentioning

confidence: 99%

Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals

Rukh,

Ullah,

Naqvi

et al. 2024

Lett. Anim. Biol.

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The growing interest in nanoparticles in modern research is due to their potential uses in different fields of study. Throughout human history, individuals have been exposed to environmental nanosized particles, and over the past century, these exposures have significantly risen. Through injection, ingestion, and inhalation, nanoparticles can change the material's physicochemical characteristics and improve its ability to absorb and interact with biological tissues. Nanoparticles can penetrate the cell membrane and reach up to mitochondria and nucleus, causing gene mutation and inhibiting the mitochondrial process involved in cell metabolism. The toxicity is associated with size, shape, charge, surface area, chemical composition, and other linked factors. The in vivo behavior of these nanoparticles is still a major question that needs to be resolved. The tests are performed against the new nanoparticles during the developmental process to eliminate or ameliorate identified toxic characteristics.

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Section: Ingestionmentioning

confidence: 99%

Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals

Rukh,

Ullah,

Naqvi

et al. 2024

Lett. Anim. Biol.

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“…Therefore, overcoming the mucosal barrier has become the main research direction for oral nanomedicine delivery systems. 7 Currently, nanomaterials used for the treatment of digestive disorders include liposomes, dendritic polymers, nanogels, biomimetic nanocarriers, extracellular vesicles (EVs), and inorganic NPs. These nanomaterials have been introduced into oral administration of drug methods to overcome biological barriers in the digestive tract and increase drug usage.…”

Section: Introductionmentioning

confidence: 99%

Nanodrug delivery materials for digestive system diseases

Yang,

Zeng,

Zhuang

et al. 2024

APL Materials

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Digestive system diseases, such as gastritis, gastric ulcers, chronic liver disease, inflammatory bowel disease (IBD), and colorectal cancer, represent a major group of diseases that have high morbidity and death rates worldwide. Their incidence continues to rise owing to factors such as dietary structure changes, accelerated lifestyles, increased environmental pollution, and population aging. Despite the rapid development of the medical technology, the treatment of digestive diseases still faces many challenges, such as addressing drug-resistant Helicobacter pylori infections, treating IBD, and improving the efficacy of advanced gastrointestinal tumor therapies. Fortunately, the emergence of drug-releasing materials has provided new insights that can be used in the treatment of digestive disorders. Drug-releasing materials are a category of specially designed carriers or systems capable of carrying drugs and controlling their release at specific time intervals on demand to achieve the desired therapeutic effect. This article reviews recent research progress of drug-releasing materials used to diagnose and treat digestive disorders. First, the limitations of traditional oral drug delivery methods, such as low bioavailability and nonspecific distribution, are discussed. Second, different types of drug-releasing materials, such as liposomes, dendritic polymers, micelles, nanogels, inorganic nanoparticles, and extracellular vesicles, along with their advantages in terms of improved drug stability, biocompatibility, targeting, and controlled release, are outlined. In addition, the application strategies and preclinical findings of various drug release materials for different digestive disorders are discussed in detail. This Review could help researchers explore more advanced nanomaterials for personalized treatment of drug delivery for digestive disorders.

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Organic Materials with Ultrabright Phosphorescence at Room Temperature under Physiological Conditions for Bioimaging

Gu,

Yuan,

Chang

et al. 2024

Angewandte Chemie

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In contrast to the high efficiency of room temperature phosphorescence in crystal states, the generally utilized nanoparticles of organic materials in bioimaging demonstrated sharply decreased performance by orders of magnitude under physiological conditions, badly limiting the realization of their unique advantages. This case, especially for organic red/near‐infrared (NIR) phosphorescence materials, is not only the challenge present in reality but more importantly, for the theoretical problem of deeply understanding and avoiding the quenching effect by oxygen and water toward excited triplet states. Herein, thanks to the intelligent molecular design by the introduction of abundant hydrophobic chains and highly‐branched structures, bright and persistent red/NIR phosphorescence under physiological conditions has been realized, which demonstrated the shielding effect towards oxygen, and strengthened the intermolecular interactions to suppress the non‐radiative transitions. Accordingly, the record phosphorescence intensity of nanoparticles in bioimage, up to 8.21 ± 0.36 × 108 p s−1 cm−2 sr−1, was achieved, to realize the clear phosphorescence imaging of liver and tumors in living mice, even lymph nodes in rabbit models with high SBRs. This work afforded an efficient way to achieve the bright red/NIR phosphorescence nanoparticles, guiding their further applications in biology and medicine.

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Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

Cited by 12 publications

References 307 publications

Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals

Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals

Nanodrug delivery materials for digestive system diseases

Organic Materials with Ultrabright Phosphorescence at Room Temperature under Physiological Conditions for Bioimaging

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