Oral Nicorandil effectively attenuates the incidence of contrast-induced nephropathy in patients undergoing cardiac catheterization: a randomized, controlled, open-label clinical trial

Moghaddam, Alireza Abdollahi; Rahimi, Vafa Baradaran; Morovatdar, Negar; Rezaee, Ramin; Babalhekam, Sadegh Alavi

doi:10.1007/s11255-023-03541-0

Cited by 7 publications

(2 citation statements)

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“…(3) moderate calcifications as only densities in cardiac cycles following contrast injection, and (4) severe as the presence of densities over the two sides of the coronary artery wall before contrast injection (11). The present study only included patients with moderate and severe calcified lesions based on the mentioned classification criteria.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of long‐term outcomes of percutaneous coronary intervention in patients with moderate to severe calcified coronary artery lesions

Ebrahimi,

Askari,

Sharifi

et al. 2023

Health Science Reports

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Background and AimsCoronary artery calcification reduces elasticity and can cause hemodynamic disturbances, increasing the risk of cardiovascular complications. Furthermore, coronary calcifications make cardiovascular interventions difficult. The present study aimed to study the cardiovascular outcomes of the coronary intervention of calcified lesions in the Iranian population.MethodsThe present cross‐sectional study evaluated patients with moderate to severe calcified coronary artery lesions on angiography who were candidates for percutaneous coronary intervention (PCI). Demographic, echocardiographic, and angiographic data of the patients were recorded. In addition, clinical outcomes, including mortality, myocardial infarction, stroke, and stent thrombosis, were also measured 1 year after the procedure.ResultsA total of 125 participants (65% male and 35% female) with a median age of 69 (13.0) years old were enrolled. The most common calcification degree was 270° (43.5%), followed by 360° (35.5%) and 180° (21.0%). Most patients had thrombolysis in myocardial infarction (TIMI) score of 3 (47.6%). A more than 10% residual coronary minimum lumen diameter was seen in 25.8% of patients. Puncture site hemorrhage and contrast‐induced nephropathy were observed in 2 (1.6%) and 1 (0.8%) patients, respectively. Following 1 year after PCI, no cases of mortality, cerebrovascular accident, myocardial infarction, and stent thrombosis were reported. Furthermore, we observed one case of heart failure (0.8%) and target lesion revascularization (0.8%). In addition, we revealed a significant relationship between calcification degree and TIMI (p < 0.001) and body mass index (p = 0.049).ConclusionPercutaneous management of calcified lesions with noncompliant balloon and one or two guidewires was associated with a good success rate and few complications.

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Section: Methodsmentioning

confidence: 99%

“…The residual coronary minimum lumen diameter (MLD) is determined as the ratio of the remaining stenosis compared to the normal state of the vessel after angioplasty. The CIN is defined as 0.5 mg/dL or a 25% increase in serum creatinine from baseline 11 …”

Section: Methodsmentioning

confidence: 99%