Oral Nicotinamide and Actinic Keratosis: A Supplement Success Story

Abstract

Nicotinamide has shown potential as a safe and effective intervention for the prevention of malignant and premalignant skin lesions. Recent studies have shown that nicotinamide, in both oral and topical forms, is able to prevent ultraviolet-induced immunosuppression in humans [1,2,3] and mice [4,5]. Immunosuppression is a known factor for the progression of premalignant lesions, such as actinic keratosis [6]. Murine studies have shown that nicotinamide is also able to protect against photocarcinogenesis [4,5]. Preliminary human studies suggest that nicotinamide may help prevent skin cancers and enhance the regression of actinic keratoses.

Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes

“…Vitamin B-3 deficiency is associated with a number of skin lesions, including pellagra-associated dermatitis, acne, dermatoses, and actinic keratosis, and NAM is efficient at improving bullous pemphigoid (Fivenson et al, 1994) and psoriasis (Levine et al, 2010;Siadat et al, 2013). Furthermore, topical and oral administration of NAM can reduce onset of UV-induced immunosuppression, a critical mechanism involved in cancer induction (Damian et al, 2008;Gensler, 1997;Yiasemides et al, 2009), and prevent nonmelanoma skin cancers (Chen et al, 2015;Kim et al, 2015). These findings highlight NAM as a promising molecule with multiple domains of application.…”

Meat Intake and the Dose of Vitamin B3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

“…There is emerging evidence that nicotinamide dosage can be (neuro)protective under a wide range of environmental insults whether traumatic, anoxic, or toxic suggesting that prophylactic boosting of the dosage or treating soon after the insult may reduce cell damage in a number of organs, including the brain. 96,104,236,261–290 Many diseases where the environmental trigger is not known may have an NAD-deficient endo-phenotype. This is suggested by the extraordinarily varied phenotype of pellagra where a wide range of dementias and neuropsychiatric conditions was described including mimics of Creutzfeldt-Jakob disease, PD, motor neuron disease, multiple sclerosis (MS), and cerebellar syndromes alongside migraine and epilepsy.…”

Vitamin B3 in der kosmetischen Dermatologie

“…Ehemals war Bierhefe zur Supplentierung eingesetzt worden. Die orale Supplementierung von Vitamin B3 erfolgt heute in Tablettenform mit 2 × 500 mg pro Tag [11]. Sie sollte aber vorsichtig gestartet werden, da Flush und Juckreiz auftreten können.…”

“…Im UV-Schutz waren 5 % aber auch niedrigere Konzentrationen von Nicotinamid effektiv in der Unterdrückung der UV-induzierten Immunsuppression. Das galt für beide Geschlechter [10,11].…”