Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Abstract

This is the unspecified version of the paper.This version of the publication may differ from the final published version. and also a significant improvement in overall lens comfort at 6 months (p<0.01). Permanent repository linkTear meniscus height was increased in the EPO group at 6 months relative to baseline (p<0.01), although all other objective signs were unchanged. Conclusion:This study provides evidence for a beneficial effect of particular orally administered omega-6 fatty acids in alleviating dry eye symptoms and improving overall lens comfort in patients suffering from contact lens associated dry eye.

Essential fatty acids in the treatment of dry eye syndrome: A myth or reality?

“…At the end of the study, 70% of the patients treated with omega-3 supplements became asymptomatic and Schirmer testing together with fluorophotometry suggested that the omega-3 supplement increased tear secretion. A similar improvement was reported by Kokke et al 24 in 76 patients with contact lens related DES following treatment with omega-6 supplements.…”

Diet, nutraceuticals and the tear film

“…Ten trials have investigated formulations of omega-6 alone or combined with antioxidants (Aragona et al, 2005;Barabino et al, 2003;Horrobin et al, 1981;Kokke et al, 2008;Macri et al, 2003;Manthorpe et al, 1984;McKendry, 1982;Oxholm et al, 1986;Pinna et al, 2007;Theander et al, 2002). The first anecdotal report of effectiveness of omega-lipid-based dietary nutraceutical was published in 1981 (Horrobin et al, 1981).…”

“…Finally, a RCT investigating the effectiveness of evening primrose oil (300 mg GLA) for contact lens dryness over 6-month demonstrated improved comfort and tear volume but no effect on tear stability, ocular surface staining or meibomian gland appearance (Kokke et al, 2008). An investigator masked notreatment control trial investigated the effectiveness of using low supplementation with 28.5 mg LA and 15 mg GLA for 1 month in patients undergoing photorefractive keratectomy (PRK) to correct their refractive error (Macri et al, 2003).…”

“…A large number of human trials have looked at the effectiveness of dietary supplementation with omega fatty acids and antioxidants alone or in combination with each other in subjects with dry eyes including Sjögren's syndrome, contact lens wear, meibomian gland dysfunction and following refractive surgery (Aragona et al, 2005;Barabino et al, 2003;Blades et al, 2001;Brignole-Baudouin et al, 2011;Creuzot-Garcher et al, 2011;Creuzot et al, 2006;Drouault-Holowacz et al, 2009;Horrobin et al, 1981;Jackson et al, 2011;Kangari et al, 2013;Kawabata and Tsuji, 2011;Kokke et al, 2008;Larmo et al, 2010;Macri et al, 2003;Macsai, 2008;Manthorpe et al, 1984;McKendry, 1982;Oxholm et al, 1986;PinazoDuran et al, 2013;Pinna et al, 2007;Theander et al, 2002;Wojtowicz et al, 2010). Topical administration of these dietary compounds and their derivatives has also been investigated in animal models but this is not the subject of this review (Cortina et al, 2010;Esquenazi et al, 2005;Li et al, 2010;Rashid et al, 2008).…”

Effects of Oral Sea Buckthorn Oil on Tear Film Fatty Acids in Individuals With Dry Eye

“…Hyperosmolarity may also induce tear film instability by activating inflammation, leading to epithelial damage that interferes with normal production of the tear film. 1,3 Combined g-linolenic (18:3n-6) and linoleic acid (18:2n-6) supplementation has shown positive effects on meibomian gland dysfunction and dry eye, [5][6][7][8][9] and consumption of n-3 fatty acids is associated with reduced risk of dry eye in women. 10 Suggested mechanisms underlying the beneficial effects of n-3 fatty acids and the combination of g-linolenic and linoleic acids include effects on inflammation, tear secretion, and tear film lipids.…”