Oral ondansetron decreases vomiting after tonsillectomy in children

Splinter, William M.; Baxter, Michael R. N.; Gould, H.M.; Hall, Leslie E.; MacNeill, Helen B.; Roberts, David; Komocar, Lydia

doi:10.1007/bf03010702

Cited by 37 publications

(18 citation statements)

References 9 publications

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“…The observed incidence of vomiting is similar to that noted in an ambulatory care setting where inhospital vomiting rates after tonsillectomy are 10-30% and increases to 20-40% after discharge. 1,s, 6 There is only one published report of perioperative dystouia after perphenazine, 7 so it was not unexpected that there were no observed adverse effects attributable to perphenazine in the current study. Perphenazine is a phenothiazine and like other medications in its drug The central nervous system dopaminergic activity of this drug which results in its antiemetic effect, may also produce extrapyramidal effects.…”

Section: Discussionsupporting

confidence: 47%

Perphenazine decreases vomiting by children after tonsillectomy

Splinter

Roberts

1997

Can J Anaesth

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Purpose: To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy. Methods: Healthy children (n = 260) aged 2-12 yr undergoing elective tonsillectomy on a day care surgical basis were studied in this randomised, stra~ed, blocked, double-blind investigation. General Anaesthesia was induced intravenously with propofol or by inhalation with halothane and N20. Perphenazine 70/Jg.kg -I up to 5 mg or placebo/v was administered before surgery, Management of perioperative fluids, emesis and pain were all standardised. ~ults: The groups were similar with respect to demographic data. There was less vomiting after perphenazine during the first 24 hr after surgery 4296 (95% CI = 34o/0-5096) vs 57% (9596 CI = 4896-6696, placebo), P < 0.01. On the day of surgery, both in and out-of hospital emesis were decreased by perphenazine. The perphenazine treated patients required fewer rescue antiemetics than the control group, P < 0.05. Each episode of in-hospital vomiting delayed discharge by 20 _+ 7 rain (mean _+ SD), P = 0.007. Conclusion= The prophylactic administration of perphenazine decreases vom~ng by children alter tonsillectomy.Objectif : V6rifier si la perph6nazine diminue l'incidence des vomissements apr~s une amygclalectomie chez l'enfant.M6thodes : Des enfants bien portants (n = 260) ~g~s de deux ~ 12 arts soumis ~ une amygdalectomie en chirurgie rEgl6e dans un centre de jour ont partidpE ~ cette investigation randomis6e, stratifl6e, avec blocs et en double aveugle. I'anesthEsie g6n&ale 6talt induite par la vole veineuse de propofol ou par inhalation d'halothane et de N20. Avant la chirurgie, on administrait iv de la perph6nazine 70/jg.kg -~ jusqu'~ 5 mg ou un placebo. La prise en charge des liquides l:~riop6ratoim~s, des vomissements et de la douleur ~tait uniformis6e.R~sultats : Les groupes 6talent comparables sous l'aspect d6mographique. Les vomissements survenaient moins souvent apr#.s la perphEnazine pendant les premieres 24 h postchiru~cales, 42% (IC 95% = 3496-50%) vs 5796 (IC 9596 = 48%-66%), P < 0.0 I. Le jour de la chirurgie, les (~pisodes 6m6tiques intra-et extrahospitaliers diminualent sous perph6nazine. Les patients trait& i~ la perph6nazine ont eu besoin de moins d'anti6m6-tiques de sauvetage que le groupe contr61e, P < 0,05. Chaclue 6pisode de vomissements intrahospitaliers a retard6 le cong~ de I0 _+ 7 min (moyenne +_ L~I'), P = 0,007.

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Section: Discussionsupporting

confidence: 47%

Perphenazine decreases vomiting by children after tonsillectomy

Splinter

Roberts

1997

Can J Anaesth

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“…The observed incidence of vomiting was similar to that reported previously. [12][13][14] Excessive intraoperative and postoperative bleeding was a major problem. We observed a 14% incidence of excessive bleeding in the kctorolac group, which is greater than the expected rate of less than 3%.…”

Section: Discussionmentioning

confidence: 99%

Preoperative ketorolac increases bleeding after tonsillectomy in children

et al. 1996

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“…Single doses of 200 mg/kg in children are not associated with hepatotoxicity [7,8,9]. Opioids are thought to have greater ecacy than acetaminophen but are associated with an incidence of postoperative vomiting of 50±70% after tonsillectomy [10,11,12]. We wished to test whether high doses of acetaminophen could produce pain relief similar to opioids but with a lower risk of vomiting.…”

Section: Introductionmentioning

confidence: 97%

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy

Anderson

Woollard

Holford

2001

European Journal of Clinical Pharmacology

130

120

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High dose acetaminophen (100 mg/kg) was no more effective than 40 mg/kg and was associated with increased nausea and vomiting. A target effect compartment concentration of 10 mg/l is expected to produce a pain reduction of 2.6 units. The placebo model accounted for a maximum pain reduction of 5.6 units at 3 h. The combination of placebo effect and preoperative acetaminophen 40 mg/kg results in pain scores below 4 units for 5 h postoperatively.

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Oral ondansetron decreases vomiting after tonsillectomy in children

Abstract: Oral ondansetron decreases vomiting after tonsillectomy in childrenVomiting is a common, unpleasant aftermath of tonsillectomy in children. Intraoperative intravenous ondansetron (OND)

Cited by 37 publications

References 9 publications

Perphenazine decreases vomiting by children after tonsillectomy

Perphenazine decreases vomiting by children after tonsillectomy

Preoperative ketorolac increases bleeding after tonsillectomy in children

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy

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