Oral or Nasal Antigen Induces Regulatory T Cells That Suppress Arthritis and Proliferation of Arthritogenic T Cells in Joint Draining Lymph Nodes

Broere, Femke; Wieten, Lotte; Koerkamp, Elles I. Klein; Roon, Joël A G van; Guichelaar, Teun; Lafeber, Floris P. J. G.; Eden, Willem van

doi:10.4049/jimmunol.181.2.899

Cited by 50 publications

(38 citation statements)

References 44 publications

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“…Development of polyarthritis, deposition of immune complexes, and the presence of rheumatoid factor are shared features with human RA. Proteoglycan, emulsified with an adjuvant, is intraperitoneally injected on days 0 and 21 and optionally also on day 42, resulting in the development of an erosive arthritis (40)(41)(42). In the earlier literature, CFA is mentioned as the adjuvant (43), whereas dimethyldioctadecylammonium bromide (DDA) is used in the more recent studies.…”

Section: Evaluation Of Therapeutic Targets In Animal Models Of Arthritismentioning

confidence: 99%

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Bevaart¹,

Vervoordeldonk²,

Tak³

2010

Arthritis & Rheumatism

232

193

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There are accumulating data describing the association between diabetes and cancer mortality from Westernised populations. There are no data describing the relationship between diabetes and cancer mortality in African or South Asian populations from developing countries. We explored the relationship of abnormal glucose tolerance and diabetes on cancer mortality risk in a large, multi‐ethnic cohort from the developing nation of Mauritius. Population‐based surveys were undertaken in 1987, 1992 and 1998. The 9559 participants comprised 66% of South Asian (Indian), 27% of African (Creole), and 7% of Chinese descent. Cox's proportional hazards model with time varying covariates was used to obtain hazard ratios (HRs) and 95% confidence intervals (95% CI) for risk of cancer mortality, after adjustment for confounding factors. In men, but not women, cancer mortality risk increased with rising 2h‐PG levels with HR for the top versus bottom quintile of 2.77 (95%CI: 1.28 to 5.98). South Asian men with known diabetes had a significantly greater risk of cancer mortality than those with normal glucose tolerance (NGT) HR: 2.74 (95%CI: 1.00‐7.56). Overall, impaired glucose tolerance was associated with an elevated risk of cancer mortality compared to NGT (HR: 1.47, 95% CI: 0.98–2.19), though this was not significant. We have shown that the association between abnormal glucose tolerance and cancer extends to those of African and South Asian descent. These results highlight the importance of understanding this relationship in a global context to direct future health policy given the rapid increase in type 2 diabetes, especially in developing nations.

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Section: Evaluation Of Therapeutic Targets In Animal Models Of Arthritismentioning

confidence: 99%

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Bevaart¹,

Vervoordeldonk²,

Tak³

2010

Arthritis & Rheumatism

232

193

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“…In vivo effect of HSP70 treated BMDC on antigen-specific T cells CD4 + T cells were isolated from spleens of DO11.10 mice and labelled with 5,6-carboxy-succinimidyl-fluorescein-ester (CFSE) as described before (Broere et al 2008). Acceptor BALB/c mice received intravenously (i.v.)…”

Section: Micementioning

confidence: 99%

Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells

Spiering

Zee

Wagenaar

et al. 2013

Cell Stress and Chaperones

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Previously, it has been shown that heat shock protein 70 (HSP70) can prevent inflammatory damage in experimental autoimmune disease models. Various possible underlying working mechanisms have been proposed. One possibility is that HSP70 induces a tolerogenic phenotype in dendritic cells (DCs) as a result of the direct interaction of the antigen with the DC. Tolerogenic DCs can induce antigen-specific regulatory T cells and dampen pathogenic T cell responses. We show that treatment of murine DCs with either mycobacterial (Mt) or mouse HSP70 and pulsed with the disease-inducing antigen induced suppression of proteoglycan-induced arthritis (PGIA), although mouse HSP70-treated DCs could ameliorate PGIA to a greater extent. In addition, while murine DCs treated with Mt-or mouse HSP70 had no significantly altered phenotype as compared to untreated DCs, HSP70-treated DCs pulsed with pOVA (ovalbumin peptide 323-339) induced a significantly increased production of IL-10 in pOVA-specific T cells. IL-10-producing T cells were earlier shown to be involved in Mt HSP70-induced suppression of PGIA. In conclusion, this study indicates that Mt-and mouse HSP70-treated BMDC can suppress PGIA via an IL-10-producing T cell-dependent manner.

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“…Similar studies in patients with multiple sclerosis, rheumatoid arthritis, relapsing polychondritis, insulin dependent diabetes mellitus, myasthenia gravis, and uveitis, justified the performance of clinical trials in select diseases [63,64,[172][173][174][175]. Furthermore, tolerization of the triggering peptide could be achieved by different routes including oral ingestion [63], nasal inhalation [176,177], intravenous infusion [178], intramuscular injection [179], and epicutaneous immunization [180].…”

Section: Autoantigen Intolerancementioning

confidence: 93%

Emerging Opportunities for Site-Specific Molecular and Cellular Interventions in Autoimmune Hepatitis

Czaja

2010

Dig Dis Sci

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Current corticosteroid-based treatments of autoimmune hepatitis frequently have incomplete or unsatisfactory outcomes, side effects, and excessive immune suppression. The goal of this review is to describe the advances in developing animal models of autoimmune hepatitis and in treating diverse immune-mediated diseases that make pursuit of site-specific molecular and cellular inventions in autoimmune hepatitis feasible. Prime source and review articles in English were selected by a Medline search through October 2009. A murine model infected with an adenovirus expressing human CYP2D6 is a resource for evaluating new therapies because of its histological and serological features, persistence, and progressive hepatic fibrosis. Synthetic analog peptides that block autoantigen expression, a dimeric recombinant human fusion protein of cytotoxic T lymphocyte antigen-4, monoclonal antibodies against tumor necrosis factor-alpha, recombinant interleukin 10, tolerization techniques for disease-triggering autoantigens, T regulatory cell transfer, vaccination against antigen-specific cytotoxic CD8+ T cells, and gene silencing methods using small inhibitory RNAs are feasible interventions to explore. Treatments directed at dampening immunocyte activation with soluble cytotoxic T lymphocyte antigen-4, inhibiting immunocyte differentiation with recombinant interleukin 10, and improving immunosuppressive activity with regulatory T cell modulation have the most immediate promise. Progress in the development of an animal model of autoimmune hepatitis and experiences in other immune-mediated diseases justify the evaluation of site-specific molecular and cellular interventions in this disease.

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Oral or Nasal Antigen Induces Regulatory T Cells That Suppress Arthritis and Proliferation of Arthritogenic T Cells in Joint Draining Lymph Nodes

Cited by 50 publications

References 44 publications

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells

Emerging Opportunities for Site-Specific Molecular and Cellular Interventions in Autoimmune Hepatitis

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