Oral pemphigus without skin lesions treated with pulse steroid therapy

Abstract

Pemphigus is an autoimmune disease affecting the skin and mucosae. Oral lesions are common and sometimes are the only manifestations of the disease. The clinical presentations of pemphigus might mimic other vesiculobullous lesions of the oral cavity. We report a case of a 60-year-old male patient who complained of erosive lesions in the oral cavity. The lesions were diagnosed as pemphigus based on histopathological examination and immunofluorescence findings. The patient did not respond to topical steroids and low doses of systemic steroids. Since the patient began developing dermatological manifestations, he was administered pulse steroid therapy. He is currently under observation and his clinical signs and symptoms show improvement, although he has developed hyperglycemia as a complication.

Pemphigus vulgaris

“…If there is no adequate response, then dose may be increased to up to 2.0-2.5 mg/kg/day. 3 Dental and periodontal follow-up is very necessary after attaining clinical remission, at least two to three times a year for the first year following diagnosis. 4…”

Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration

“…Pemphigus vulgaris is an autoimmune disease that affects the skin and mucous membranes. It manifests in oral cavity as painful erosive lesions (ulcers) that are usually treated with corticosteroids (116). In such cases, the repeated injections of PRP accelerate tissue healing and reduce pain and discomfort during mastication (106).…”

Role of oral physician in the management of pemphigus vulgaris- A geriatric case report

“…The pathology involves formation of circulating immunoglobulin G autoantibodies against the desmosomal adhesion molecules namely cadherins and desmoglein 1 and 3 present in the epithelium. Desmoglein 1(dsg-1) is associated with the epithelial cells of skin, while desmoglein 3 (dsg-3) is associated with the cells of oral mucosa (4). There are clinically five different types of pemphigus namely P. vulgaris, P. foliaceus, Paraneoplastic pemphigus, IgA pemphigus and drug-induced pemphigus.…”