Oral Penicillin in the Treatment of Neisserian Infections

Treatment of Gonorrhoea with Penicillin Preparations

“…In attempts to avoid the destruction of penicillin during passage through the stomach, lanoline, sesame oil, cocoa butter and other enteric‐coated capsules have been used (Seager et al 1946) as have magnesium oxide, aluminium hydroxide and calcium carbonate and other buffers (Cohn et al 1946 ; Johnson et al 1951). A preparation on the current market is ‘Falapen’ containing 500,000 units of penicillin G with a polymer coating buried within the tablet (to provide the exterior penicillin for quick and the enclosed penicillin for slow release) which it is claimed may be given once every four hours.…”

Discussion on the Use of Penicillin in Urology

“…All the workers observed that the resultant blood and urine levels showed considerable wastage as compared withparenteral injection. Seager et al (1946), investigating the effect of oral penicillin, used resin-coated capsules, and found that three to six times the intramuscular dose was necessary to produce equal blood concentrations. Nevertheless, since penicillin is now freely available, we agree with Heatley (1945) that the convenience of oral administration will, in some cases, more than compensate for the larger amounts of the drug required.…”