Oral phosphodiesterase-5 inhibitors and sperm functions

Mostafa, Taymour

doi:10.1038/ijir.2008.29

Cited by 13 publications

(8 citation statements)

References 56 publications

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“…The exact molecular events involved are not understood, but it was hypothesized that this acute effect could be due to changes in ionic channel or adenylyl and guanylyl cyclases, which catalyze the formation of cyclic AMP and GMP, respectively, and regulate the levels of these second messengers in cells of reservoir spermatozoa in epididymis and vas deferens (38)(39)(40)(41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of blood transfusion on pituitary gonadal axis and sperm parameters in adolescents and young men with thalassemia major: a pilot study

Soliman

Yasin

Elawwa

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Acute effects of blood transfusion on pituitary gonadal axis and sperm parameters in adolescents and young men with thalassemia major: a pilot study

Soliman

Yasin

Elawwa

et al. 2012

Fertility and Sterility

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“…Another study suggested that PDE5 inhibitors could have a negative effect on male fertility by causing premature acrosome reaction [ 17 ]. Although studies have reported conflicting results about the influence of PDE5 inhibitors on sperm function, these data suggest the necessity of obtaining more reliable data about safety aspects related to the use of PDE5 inhibitors and fertilization process [ 18 19 ]. This is an especially important issue since the daily use of a PDE5 inhibitor has become a widespread regimen.…”

Section: Discussionmentioning

confidence: 99%

Usage and perceptions of phosphodiesterase type 5 inhibitors among the male partners of infertile couples

Song

Kim

Shim

et al. 2016

Clin Exp Reprod Med

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ObjectiveWe aimed to investigate the prevalence of erectile dysfunction (ED) and the usage of phosphodiesterase type 5 (PDE5) inhibitors for ED treatment in infertile couples.MethodsA total of 260 male partners in couples reporting infertility lasting at least 1 year were included in this study. In addition to an evaluation of infertility, all participants completed the International Index of Erectile Function (IIEF)-5 questionnaire to evaluate their sexual function. The participants were asked about their use of PDE5 inhibitors while trying to conceive during their partner's ovulatory period and about their concerns regarding the risks of PDE5 inhibitor use to any eventual pregnancy and/or the fetus.ResultsBased on the IIEF-5 questionnaire, 41.5% of the participants (108/260) were classified as having mild ED (an IIEF-5 score of 17–21), while 10.4% of the participants (27/260) had greater than mild ED (an IIEF-5 score of 16 or less). The majority (74.2%, 193/260) of male partners of infertile couples had a negative perception of the safety of using a PDE5 inhibitor while trying to conceive. Only 11.1% of men (15/135) with ED in infertile couples had used a PDE5 inhibitor when attempting conception.ConclusionED was found to be common in the male partners of infertile couples, but the use of PDE5 inhibitors among these men was found to be very low. The majority of male partners were concerned about the risks of using PDE5 inhibitors when attempting to conceive. Appropriate counseling about this topic and treatment when necessary would likely be beneficial to infertile couples in which the male partner has ED.

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“…The exact molecular events involved are not understood but it was hypothesized that this acute effect could be due to changes in ionic channel or adenylyl and guanylyl cyclase, which catalyze the formation of cAMP and cyclic-guanosine monophosphate (cGMP), and regulate the levels of these second messengers in cells of reservoir spermatozoa in epididymis and vas deferens. [464748]…”

Section: Discussionmentioning

confidence: 99%

Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?

Soliman

Yasin

Elawwa

et al. 2013

Indian J Endocr Metab

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Objective:We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults with sickle cell disease (SCD) on top-up transfusion (TTx) and those on exchange transfusion (ETx) regimen.Materials and Methods:Basal serum concentrations of FSH, LH, and T and semen parameters were evaluated before and 7 days after PCTx in 18 young adults with transfusion-dependent SCD, aged 20.7 ± 2.88 years. They had full pubertal development (Tanner's stage 5), and capacity to ejaculate. They were regularly transfused since early childhood. Chelation therapy was started early during the first 2 years of life using desferrioxamine and was replaced by deferasirox for the last 4-5 years. Ten patients were on TTx and eight were on ETx regimen.Results:PCTx significantly increased hemoglobin (Hb) from 8.5 ± 1.17 g/dl to 10.5 ± 0.4 g/dl, T from 12.3 ± 1.24 nmol/L to 14.23 ± 1.22 nmol/L and gonadotropins’ concentrations. Sperm parameters improved significantly after PCTx including: total sperm count from 87.4 ± 24.6 million/ml to 146.2 ± 51.25 million/ml, total progressive sperm motility (TPM) from 40.8 ± 11.1 million/ml to 93.4 ± 38.3 million/ml, rapid progressive sperm motility (RPM) progressive motility from 29.26 ± 8.75 million/ml to 67.4 ± 29 million/ml. After PCTx the total sperm count, TPM and RPM were significantly better in the ETx group versus the TTx group. Before and after PCTx, T concentrations were correlated significantly with sperm total count, volume, TPM and RPM (r = 0.53, 0.55, 0.42, and 0.38, respectively, P < 0.01). Hb concentrations were correlated significantly with sperm count, TPM, RPM, and % of sperms with normal morphology (r = 0.60, 0.69, 0.66, and 0.86, respectively, P < 0.001).Conclusion:Our study suggests that in males with SCD blood transfusion is associated with significant acute enhancement of sperm parameters and with increased concentrations of serum T, LH, and FSH. Improvement of sperm parameters were significantly better in the ETx group verses the TTx group. These “acute” effects on spermiogenesis are reached with an unknown mechanism/s and suggest a number of pathways that need further human and/or experimental studies.

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Oral phosphodiesterase-5 inhibitors and sperm functions

Cited by 13 publications

References 56 publications

Acute effects of blood transfusion on pituitary gonadal axis and sperm parameters in adolescents and young men with thalassemia major: a pilot study

Acute effects of blood transfusion on pituitary gonadal axis and sperm parameters in adolescents and young men with thalassemia major: a pilot study

Usage and perceptions of phosphodiesterase type 5 inhibitors among the male partners of infertile couples

Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?

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