Oral potential malignant disorders – A long list not to be forgotten

Sakthivel, Pirabu; Raveendran, Sarath; Panda, Smriti; Singh, Chirom Amit

doi:10.1016/j.oraloncology.2021.105244

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…The most elevated excess absolute risk of developing solid cancer was observed for tumors of the oral cavity (overall 2.66 EAR, of which 1.08 tongue, 0.68 lip, 0.47 gum, and 0.43 salivary gland) [ 30 ]. GvHD is not present only in FA patients and it is one of the main risk factors for oral cancer [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

et al. 2022

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Objectives The aim of this retrospective study was to determine the incidence and the clinical outcome of tongue cancer (TC) in patients affected by Fanconi anemia (FA) who received an allogeneic hematopoietic cell transplantation (HCT). Materials and methods The patient database from the Bone Marrow Transplant Center of Pescara was reviewed to enroll FA patients. Patients’, donors’, HCT’s, and screening’s data were collected as well to look for the incidence and the treatment of TC. Results Twelve patients affected by FA were identified. Three patients died for transplant-related causes. Five of nine surviving patients were diagnosed with TC at a median of 21.7 years since transplantation and at a median age of 32.10 years. Interestingly, no patient manifested graft-versus-host-disease (GvHD). The 28-year cumulative incidence function of TC was 46.9% (95% CI, 36.9–56.9%). Two patients were treated with chemotherapy alone, two patients were treated with surgery alone, and one with surgery followed by chemotherapy. Overall, 4 patients with TC showed a clinical course characterized by a marked aggressiveness of the tumor disease which led to death due to cancer progression between 2 and 13 months. One patient is surviving 8 months after diagnosis of TC. Conclusions Our study confirms the high incidence of tumors and in particular tongue tumors in allotransplanted FA patients. A careful screening has to be life-long maintained. Clinical relevance Considering the rarity of FA and the frailty of FA patients, this study may add important information for the cancer management of these patients.

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Section: Discussionmentioning

confidence: 99%

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

et al. 2022

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“…Other aetiological factors include UV radiation (lip cancer), low socioeconomic status, ionising radiation and genetic syndromes associated with the impairment of genes responsible for DNA repair and induced cell death (e.g., Li Fraumeni syndrome, Fanconi anaemia), riboflavin and iron deficiency (Plummer-Vinson syndrome) and lupus and syphilis-like lesions [6,[27][28].…”

Section: Ethiologymentioning

confidence: 99%

“…These conditions include whitish (leukoplakia) and red patches (erythroplasia, erythroplakia), lichen planus and rhomboid tongue inflammation. Conditions directly leading to the development of malignancy include small-, mediumand high-grade squamous metaplasia or dysplasia and carcinoma in situ [27,[29][30]. SCC accounts for more than 90% of all OCs [31][32].…”

Section: Histologymentioning

confidence: 99%

The management of oral cancer – current standards and future perspectives. Review of the literature

Amrogowicz,

Rutkowski

2024

Nowotwory. Journal of Oncology

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“…OPMDs have a statistically increased risk of progression into cancer. The most common OPMDs are oral submucous fibrosis (OSMF), leukoplakia, lichen planus, and erythroplakia 95 . However, investigations into OPMDs were limited by the lack of means to analyze the small amount of cellular material 96 .…”

Section: In‐depth Study Of Oral Diseases Using Scrna‐seqmentioning

confidence: 99%

“…The most common OPMDs are oral submucous fibrosis (OSMF), leukoplakia, lichen planus, and erythroplakia. 95 However, investigations into OPMDs were limited by the lack of means to analyze the small amount of cellular material. 96 With the ability of assessing transcriptome heterogeneity and the requirement of low quantities of starting material, scRNA‐seq can solve these problems.…”

Section: In‐depth Study Of Oral Diseases Using Scr...mentioning

confidence: 99%

Single‐cell RNA sequencing in oral science: Current awareness and perspectives

Ding

Wang

et al. 2022

Cell Proliferation

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The emergence of single-cell RNA sequencing enables simultaneous sequencing of thousands of cells, making the analysis of cell population heterogeneity more efficient. In recent years, single-cell RNA sequencing has been used in the investigation of heterogeneous cell populations, cellular developmental trajectories, stochastic gene transcriptional kinetics, and gene regulatory networks, providing strong support in life science research. However, the application of single-cell RNA sequencing in the field of oral science has not been reviewed comprehensively yet. Therefore, this paper reviews the development and application of single-cell RNA sequencing in oral science, including fields of tissue development, teeth and jaws diseases, maxillofacial tumors, infections, etc., providing reference and prospects for using single-cell RNA sequencing in studying the oral diseases, tissue development, and regeneration. | INTRODUCTIONOn the analysis of mixed samples of thousands of cells, bulk RNA sequencing is prone to uncover gene expression by sequencing on average in the absence of the cellular transcriptome heterogeneity of individual cells. Traditional RNA sequencing can reveal information of dominant cell subpopulations, but the transcriptome characteristics of rare cell subpopulations cannot be shown because the results are † Authors contributing equally to this article.

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Oral potential malignant disorders – A long list not to be forgotten

Cited by 8 publications

References 12 publications

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

The management of oral cancer – current standards and future perspectives. Review of the literature

Single‐cell RNA sequencing in oral science: Current awareness and perspectives

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