Oral Potentially Malignant Disorders: An Overview of More than 20 Entities

Mortazavi, Hamed; Baharvand, Maryam; Mehdipour, Masoumeh

doi:10.5681/joddd.2014.002

Cited by 80 publications

(25 citation statements)

References 63 publications

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“…Currently identified OPMDs that are associated with a high risk of MT include leukoplakia, proliferative verrucous leukoplakia (PVL), erythroplakia, oral lichen planus (OLP), oral submucous fibrosis (OSMF), actinic cheilitis, palatal lesions of reverse cigar smoking, discoid lupus erythematosus, dyskeratosis congenita, oral lichenoid lesions, and oral graft versus host disease ( Figure 2 ) ( Mortazavi et al, 2014 ; Warnakulasuriya et al, 2020a ).…”

Section: Oral Potentially Malignant Disordersmentioning

confidence: 99%

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

2022

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Section: Oral Potentially Malignant Disordersmentioning

confidence: 99%

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

2022

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“…Oral cancer is often preceded by clinically noticeable lesions that are initially noncancerous, termed as precancerous lesions like oral submucous fibrosis (OSMF) [ 1 , 2 ]. Molecular markers found in body fluids such as urine, blood, and saliva can help diagnose oral cancer, determine prognosis, and monitor its development [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hematological Profile in Oral Submucous Fibrosis

Abidullah¹,

Gaddikeri²,

Anjum³

et al. 2022

Cureus

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Background: The aim of the study is to assess the hematological profile in oral submucous fibrosis (OSMF) patients.Methods: The study's participants (100) were divided into two groups. Group I consisted of fifty areca nut chewers with complaints of burning sensations, blanching, and stiffness of the oral mucosa. Group II consisted of fifty healthy patients as controls. A hematological profile was estimated in all subjects.Results: The control group had a mean hemoglobin (Hb) of 13.87±1.26 g/dL, while the OSMF group had a mean Hb of 11.03±2.16 g/dL (P=0.001). The mean serum iron level in the control group was 120.36±41.22 g/dL, while it was 44.97±13.45 g/dL in the OSMF group (P=0.001). The control group's mean serum vitamin B12 values were 424.77±110.95 g/dL, while the OSMF group's was 210.11±44.88 g/dL (P=0.001). In the research population, 47 patients had iron deficiency. The odds ratio (OR) was 28.11, which meant that the high prevalence of iron deficiency was predicted 28.11 times more often than in the control group. Conclusion:As part of a biochemical assessment, iron status is assessed as part of a prevention mechanism for people who are at high risk. Biochemical testing has been suggested as a potential tool for mass screening OSMF patients.

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“…The high‐risk oral habits such as chewing tobacco products, smoking and drinking alcohol can be the source of high concentrations of toxic substances for oral mucosa [ 7 , 8 ]. Chronic exposure of the high‐risk factors frequently leads to a potentially malignant disorder called oral leukoplakia (OL), a white patch‐like oral lesion, diagnosed by exclusion of other known oral diseases that do not carry increased risk for cancer [ 9 , 10 ]. The final common impact of the toxic chemicals released from these products is oxidative damage within the oral epithelial cells, resulting in DNA damage, chromosomal alterations and carcinogenesis [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia

et al. 2022

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Oral squamous cell carcinoma (OSCC) is often preceded by a white patch on a surface of the mouth, called oral leukoplakia (OL). As accelerated telomere length (TL) shortening in dividing epithelial cells may lead to oncogenic transformation, telomere length measurement could serve as a predictive biomarker in OL. However, due to high variability and lack of a universal reference, there has been a limited translational application. Here, we describe an approach of evaluating TL using paired peripheral blood mononuclear cells (PBMC) as an internal reference and demonstrate its translational relevance. Oral brush biopsy and paired venous blood were collected from 50 male OL patients and 44 male healthy controls (HC). Relative TL was measured by quantitative PCR. TL of each OL or healthy sample was normalized to the paired PBMC sample (TL ratio). In OL patients, the mean TL ratio was significantly smaller not only in the patch but also in distal normal oral tissue, relative to healthy controls without a high‐risk oral habit. Dysplasia was frequently associated with a subgroup that showed a normal TL ratio at the patch but significantly smaller TL ratio at a paired normal distal site. Our data suggest that evaluation of TL attrition using a paired PBMC sample eliminates the requirement of external reference DNA, makes data universally comparable and provides a useful marker to define high‐risk OL groups for follow‐up programs. Larger studies will further validate the approach and its broader application in other premalignant conditions.

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Oral Potentially Malignant Disorders: An Overview of More than 20 Entities

Cited by 80 publications

References 63 publications

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

Evaluation of Hematological Profile in Oral Submucous Fibrosis

A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia

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