Oral prednisone in the treatment of acne agminata

Abstract

Acne agminata (lupus miliaris disseminatus faciei), once regarded as a tuberculide, is a facial granulomatous disease still seen in young adults in Japan, despite a decrease in the incidence of tuberculosis. Although most lesions regress within a few years, even without treatment, disfiguring scars remain on the face. We have evaluated the efficacy of low dose oral prednisone therapy because, in the past, there has been no satisfactory therapy for this condition. We have treated four patients with acne agminata with prednisone, at first 10 mg daily for 2 weeks, decreasing to 5 mg daily for 3 months. This modest dosage was found to give an excellent result in three patients and a poor result in one whose treatment was started at a much later stage of the disease than in the others. Acne agminata can be cured without scar formation when oral steroids are started in an early phase of the disease.

Intramuscular Triamcinolone Acetonide for Lupus Miliaris Disseminatus Faciei

“…For treatment of this condition, antibiotics (9, 10), dapsone (11) and oral steroids (12) have been reported to show variable success. Based on the close correlation ofthe inflammation in LMDF with the pilosebaceous apparatuses, immunosuppressants would be expected to have a therapeutic effect.…”

Extrafacial nuchal lupus miliaris disseminatus faciei

“…Various treatments are reported in the literature, but specific treatment guidelines are lacking. Retinoid, anti-inflammatory, immunosuppressive, and antimicrobial medications as well as laser therapy have been used for the treatment of LMDF, but no single agent is consistently effective 8, 12, 13. Tetracyclines are commonly used as a first-line treatment, but their efficacy in this disorder is often unsatisfactory.…”

“…Tetracyclines are commonly used as a first-line treatment, but their efficacy in this disorder is often unsatisfactory. Treatment with oral prednisolone has been found to prevent scarring when initiated early in the disease course 12 . Given the rarity of LMDF and its tendency to spontaneously resolve, the effect of different therapies on the disorder is difficult to evaluate.…”

Estudio Descriptivo: Granulomas Faciales Idiopáticos con Evolución Regresiva, ¿Es el Lupus Miliar Diseminado Facial un Sinónimo?

“…En lo referente al tratamiento, todos los pacientes tuvieron una respuesta adecuada a la Prednisona, coincidiendo con lo reportado en la literatura, motivo adicional para dar a conocer que esta patología no tiene relación con tuberculosis, ni rosácea, puesto que los pacientes habrían empeorado [18,19].…”