Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts

Könönen, Eija; Gürsoy, Ulvi Kahraman

doi:10.3389/fmicb.2021.798763

Cited by 61 publications

(46 citation statements)

References 95 publications

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“…Many Prevotella organisms of oral origin seem to be important players in the gastrointestinal and respiratory tracts during health and disease [ 16 ]. Prevotella constitutes a significant part of oral microbial communities; however, species-level data are still scarce due to a considerable expansion within the genus during the past two decades.…”

Section: Introductionmentioning

confidence: 99%

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Könönen

Fteita

Gürsoy

et al. 2022

Journal of Oral Microbiology

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Oral Prevotella are known as anaerobic commensals on oral mucosae and in dental plaques from early life onwards, including pigmented P. melaninogenica, P. nigrescens, and P. pallens and non-pigmented Prevotella species. Many Prevotella species contribute to oral inflammatory processes, being frequent findings in dysbiotic biofilms of periodontal diseases ( P. intermedia, P. nigrescens ), cariotic lesions ( P. denticola, Alloprevotella (formerly Prevotella ) tannerae ), endodontic infections ( P. baroniae, P. oris, P. multisaccharivorax ), and other clinically relevant oral conditions. Over the years, several novel species have been recovered from the oral cavity without knowledge of their clinical relevance. Within this wide genus, virulence properties and other characteristics like biofilm formation seemingly vary in a species- and strain-dependent manner, as shown for the P. intermedia group organisms ( P. aurantiaca, P. intermedia, P. nigrescens , and P. pallens ). Oral Prevotella species are identified in various non-oral infections and chronic pathological conditions. Here, we have updated the knowledge of the genus Prevotella and the role of Prevotella species as residents and infectious agents of the oral cavity, as well as their detection in non-oral infections, but also gathered information on their potential link to cancers of the head and neck, and other systemic disorders.

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Section: Introductionmentioning

confidence: 99%

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Könönen

Fteita

Gürsoy

et al. 2022

Journal of Oral Microbiology

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“…P. oris is a bacteria that is known to originate from the oral cavity and is enriched in gastric cancer samples. Our research showed it was enriched in the ESCC and GC cancer groups [ 30 ]. To determine any differences between the relationship of F. nucleatum abundance in cancer and normal tissues, the expression count was normalized using DESeq2, which indicated a significant difference (CRC LogFC = 1.755, Adj.…”

Section: Resultsmentioning

confidence: 99%

Whole-Transcriptome Sequencing Reveals Characteristics of Cancer Microbiome in Korean Patients with GI Tract Cancer: Fusobacterium nucleatum as a Therapeutic Target

et al. 2022

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Remarkable progress has occurred over the past two decades in identifying microbiomes affecting the human body in numerous ways. The microbiome is linked to gastrointestinal (GI) tract cancer. The purpose of this study was to determine if there is a common microbiome among GI tract cancers and how the microbiome affects the disease. To ensure ethnic consistency, Korean patients with GI tract cancer were selected. Fusobacterium nucleatum is an enriched bacteria in all cancer tissues. F. nucleatum is a Gram-negative obligate anaerobe that promotes colorectal cancer. Through Gene Set Enrichment Analysis (GSEA) and Differentially Expressed Genes (DEG) analyses, the upregulation of the G2M checkpoint pathway was identified in the F. nucleatum-high group. Cell viability and G2M checkpoint pathway genes were examined in MC 38 cells treated with F. nucleatum. F. nucleatum upregulated the expression of G2M checkpoint pathway genes and the cell proliferation of MC 38 cells. F. nucleatum facilitated cancer’s use of G2M checkpoint pathways and F. nucleatum could be a therapeutic target in Korean GI tract cancer.

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“…Comparisons of bacterial genus among the three groups of HTN-CKD, nonHTN-CKD, and HC demonstrated that Prevotella 7 plays a role in CKD, regardless of the complication of hypertension. Prevotella spp., a proteolytic/amino acid–degrading bacteria, can break down proteins and peptides into amino acids and degrade them further via specific pathways to produce short-chain fatty acids [ 27 ], and its species are considered commensal microbes in the oral cavity [ 28 ]. However, several recent studies demonstrated that Prevotella is associated with diseases, such as periapical infection [ 29 ], gout [ 30 ], and multiple sclerosis [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?

Liu

Sheng

et al. 2022

J Transl Med

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Background The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control study with matched confounding variables on the salivary microbiome in CKD and the influence of diabetes and hypertension on the microbiome has never been reported. Methods In our study, we compared the salivary microbiome profile between patients with CKD and healthy controls (HC) using 16S ribosomal DNA sequencing and examine its association with diabetes, hypertension, and immunity. Results We observed that the bacterial community was skewed in the saliva of CKD, with increased Lautropia and Pseudomonas, and decreased Actinomyces, Prevotella, Prevotella 7, and Trichococcus. No difference in the bacterial community between the CKD patients complicated with and without diabetes, and between those with and without hypertension. Prevotella 7 declined in CKD patients with/without hypertension with respect to HC, while Pseudomonas increased in CKD patients with/without hypertension. Pseudomonas was negatively associated with immunoglobin G in CKD patients. Both CKD patients with positive and negative antistreptolysin O had declined Prevotella 7 and Trichococcus compared to HC, whereas increased Pseudomonas. Conclusions Our study identifies a distinct bacterial saliva microbiome in CKD patients characterized by alteration in composition. We unravel here that the co-occurrence diseases of diabetes and hypertension are not associated with specific bacterial alterations, suggesting that bacterial dysbiosis in saliva plays a role in renal damage regardless of the occurrence of diabetes and hypertension.

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Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts

Cited by 61 publications

References 95 publications

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Whole-Transcriptome Sequencing Reveals Characteristics of Cancer Microbiome in Korean Patients with GI Tract Cancer: Fusobacterium nucleatum as a Therapeutic Target

Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?

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