Oral probiotic therapy improves motor function in a rodent model of sensorimotor stroke

Daniele, E.; Nazer, Y.; Kortebi, I.; Casasbuenas, D. Lozano; Fan, Y.; Trinh, M.; Tompkins, T. A.; Faiz, M.

doi:10.1007/s00221-023-06651-4

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…We identified 140 articles, of which 32 articles were deemed irrelevant to our research topic, nine were reviews, two were letters to the editor, one was an editorial, one was a perspective piece, one was a comment, one was a duplicate publication, and one was an un‐peer‐reviewed preprint; these were excluded by two authors who independently assessed the articles. Ultimately, 92 studies, 5–96 including 38 human studies and 54 animal studies, were selected as being highly relevant to our research topic. The flowchart of the article selection process is depicted in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

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Role of gut microbiota in ischemic stroke: A narrative review of human and animal studies

Chen,

Du,

Cui

et al. 2024

Neuroprotection

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The high incidence, mortality, and disability associated with ischemic stroke pose a significant threat to human health. The intestinal microbiota significantly influences the onset, progression, and prognosis of ischemic stroke. Gut flora plays a pivotal role in brain–gut interactions. The reflection of changes in the gut and brain caused by gut microbes facilitates the investigation of early warning biomarkers and potential therapeutic targets for ischemic stroke. In this narrative review of the relationship between gut microbiota and ischemic stroke, we primarily discuss three topics, grounded in real‐world human and animal studies. First, we examined the relationship between ischemic stroke and intestinal microbiota and its metabolites, delineate the overall characteristics of intestinal microbiota dysregulation in ischemic stroke, and assess the potential clinical value, prevailing research controversies, and unique phenomena of intestinal microbiota metabolites such as trimethylamine N‐oxide and short‐chain fatty acids in ischemic stroke. Second, we explored the potential communication pathways between intestinal flora and ischemic stroke based on the brain–gut axis, encompassing metabolic pathways, immune pathways, and neural pathways. Finally, we encapsulated the factors influencing the severity of ischemic stroke via intestinal flora, the pharmacological and nonpharmacological interventions that modulate intestinal flora in treating ischemic stroke, and the current research landscape of intestinal flora in the context of ischemic stroke sequelae.

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Section: Methodsmentioning

confidence: 99%

“…Daniele et al 88 B. longum R0175 and L. helveticus R0052 Improving functional recovery and changed the composition of the poststroke gut microbiota.…”

Section: Study Probiotics Potential Mechanismmentioning

confidence: 99%

Role of gut microbiota in ischemic stroke: A narrative review of human and animal studies

Chen,

Du,

Cui

et al. 2024

Neuroprotection

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Therapeutic approaches targeting the gut microbiota in ischemic stroke: current advances and future directions

MAO,

ZHANG,

GUO

et al. 2024

Bioscience of Microbiota, Food and Health

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Ischemic stroke (IS) is the predominant form of stroke pathology, and its clinical management remains constrained by therapeutic time frame. The gut microbiota (GM), comprising a multitude of bacterial and archaeal cells, surpasses the human cell count by approximately tenfold and significantly contributes to the human organism's growth, development, and overall well-being. The microbiota-gut-brain axis (MGBA) in recent years has established a strong association between gut microbes and the brain, demonstrating their intricate involvement in the progression of IS. The regulation of IS by the GM, encompassing changes in composition, abundance, and distribution, is multifaceted, involving neurological, endocrine, immunological, and metabolic mechanisms. This comprehensive understanding offers novel insights into the therapeutic approaches for IS. The objective of this paper is to examine the mechanisms of interaction between the GM and IS in recent years, assess the therapeutic effects of the GM on IS through various interventions, such as dietary modifications, probiotics, fecal microbiota transplantation, and antibiotics, and offer insights into the potential clinical application of the GM in stroke treatment.

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Oral probiotic therapy improves motor function in a rodent model of sensorimotor stroke

Cited by 2 publications

References 44 publications

Role of gut microbiota in ischemic stroke: A narrative review of human and animal studies

Role of gut microbiota in ischemic stroke: A narrative review of human and animal studies

Therapeutic approaches targeting the gut microbiota in ischemic stroke: current advances and future directions

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