Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy

Farr, Alex; Sustr, Valentina; Kiss, Herbert; Rosicky, Ingo; Gráf, Alexandra; Makristathis, Athanasios; Foessleitner, Philipp; Petricevic, Ljubomir

doi:10.1038/s41598-020-76896-4

Cited by 21 publications

(19 citation statements)

References 39 publications

(38 reference statements)

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“…Probiotics with their antimicrobial potential could be used to support healthy gut and VMB and thus reduce GBS colonization. No impact on GBS colonization was found with consumption of four-strain probiotic blend L. jensenii Lbv116, L. crispatus Lbv88, L. rhamnosus Lbv96, and L. gasseri Lbv150 when consumed for 2 weeks in GBS-positive women with 33-37 weeks of gestation (Farr et al, 2020). Furthermore, no significant impact on GBS colonization was observed in an open-label trial of 10 women with a probiotic combination containing L. acidophilus strains La-14 and NCFM, Bifidobacterium animalis subsp.…”

Section: Probioticsmentioning

confidence: 89%

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Lehtoranta¹,

Ala-Jaakkola²,

Laitila³

et al. 2022

Front. Microbiol.

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Vaginal microbiota plays a central role in women’s health and reproduction. Vaginal microbiota is dynamic and shaped by hormonal shifts in each stage of a woman’s life from pre-puberty to postmenopause. Current research has mainly focused on vaginal bacterial and fungal members of the community and emphasized their role in disease. However, the impact of balanced vaginal microbiota on health and its interaction with the host is yet poorly understood. High abundance of vaginal lactobacilli is most strongly associated with health, but the concept of health may vary as vaginal dysbiosis may be asymptomatic. Furthermore, there is a lot of variation between ethnic groups in terms of dominating vaginal bacteria. Probiotic lactobacilli could be a safe and natural means to balance and maintain healthy vaginal microbiota. Research evidence is accumulating on their role in supporting women’s health throughout life. This review describes the current literature on vaginal microbiota, the major factors affecting its composition, and how the communities change in different life stages. Furthermore, we focused on reviewing available literature on probiotics and their impact on vaginal microbiota and health.

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Section: Probioticsmentioning

confidence: 89%

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Lehtoranta¹,

Ala-Jaakkola²,

Laitila³

et al. 2022

Front. Microbiol.

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“…Moreover, there is striking evidence for an increased risk of PTB through vaginal infections, as well as for an association between the oral and the vaginal microbiome (e.g., low hygiene status is associated with increased bv risk) [ 89 , 90 ]. Indeed, an antenatal infection screen-and-treat program might be useful in routine pregnancy care to prevent PTB, LBW, and adverse pregnancy outcomes [ 89 , 91 ].…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Ferrillo

Migliario

Roccuzzo

et al. 2021

JCM

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Periodontal disease seems to be correlated with low vitamin D serum levels, preterm birth (PTB) and low birth weight (LBW), although the literature still lacks a consensus. This study aimed to investigate this correlation in a cohort of pregnant women over 20 weeks of gestation from the University Hospital “Maggiore della Carità”, Novara, Italy. We assessed serum levels of vitamin D and oral health status through the following indexes: Oral Hygiene Index (OHI), Plaque Control Record (PCR), Gingival Bleeding Index (GBI), and Community Periodontal Index of Treatment Needs (CPTIN). Moreover, we assessed the number of PTB and LBW among the newborns. Out of 121 pregnant women recruited, 72 (mean age 29.91 ± 3.64 years) were included. There was a statistically significant correlation between preterm and OHI > 3 (p = 0.033), and between LBW and OHI > 3 (p = 0.005) and CPITN = 3 (p = 0.027). Both pregnant women with vitamin D deficiency ((25-hydroxy-vitamin D) < 30 ng/mL) and PTB plus LBW newborns were significantly correlated (p < 0.05) with poor levels of all oral health status indexes during pregnancy. Furthermore, these conditions (women with hypovitaminosis D and combination of PTB and LBW) were shown to be significantly correlated (p < 0.001). Taken together, our findings reported a high prevalence of PTB and LBW with poor oral health and vitamin D deficiency in pregnant women.

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“…The population was Caucasian in three studies [ 33 , 35 , 36 ] while one study also included Hispanic and other ethnicities [ 34 ]; the remnant one was conducted on Asian women [ 32 ]. The sample size ranged from 34 to 151 pregnant women.…”

Section: Resultsmentioning

confidence: 99%

“…All of the included studies tested oral supplementation with probiotics. Probiotic strains were the same in four of the studies ( Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 L ) [ 32 , 33 , 34 , 35 ], while Lactobacillus jensenii Lbv116 , Lactobacillus crispatus Lbv88 , Lactobacillus rhamnosus Lbv96 , and Lactobacillus gasseri Lbv150 were used in the remnant study [ 36 ]. Doses ranged from 1 ×108 CFU to 5.4 ×109 CFU daily.…”

Section: Resultsmentioning

confidence: 99%

Supplementation of Probiotics in Pregnant Women Targeting Group B Streptococcus Colonization: A Systematic Review and Meta-Analysis

et al. 2022

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This systematic review and meta-analysis aimed to determine if probiotic supplementation in pregnancy reduced maternal Group B streptococcus (GBS) recto-vaginal colonization in pregnant women at 35–37 weeks of gestation. Electronic databases (i.e., PubMed, MEDLINE, ClinicalTrials.gov, ScienceDirect, and the Cochrane Library) were searched from inception up to February 2022. We included RCTs assessing the effects of probiotic supplementation in pregnancy on GBS recto-vaginal colonization. The primary outcome was GBS-positive recto-vaginal cultures performed at 35–37 weeks of gestation. Secondarily, we evaluated obstetric and short-term neonatal outcomes. A total of 132 publications were identified; 9 full-length articles were reviewed to finally include 5 studies. Probiotic supplementation reduced vaginal GBS colonization: the GBS positive culture rate was estimated at 31.9% (96/301) in the intervention group compared to 38.6% (109/282) in the control group (OR = 0.62, 95% CI 0.40–0.94, I2 4.8%, p = 0.38). The treatment started after 30 weeks of gestation and was more effective in reducing GBS colonization (OR 0.41, 95% CI 0.21–0.78, I2 0%, p = 0.55). Probiotic administration during pregnancy, namely in the third trimester, was associated with a reduced GBS recto-vaginal colonization at 35–37 weeks and a safe perinatal profile. Whether this new strategy could reduce the exposition of pregnant women to significant doses of antibiotics in labor needs to be evaluated in other trials.

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Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy

Cited by 21 publications

References 39 publications

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Supplementation of Probiotics in Pregnant Women Targeting Group B Streptococcus Colonization: A Systematic Review and Meta-Analysis

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