Oral Propolis Nanoemulsions Modulate Gut Microbiota to Balance Bone Remodeling for Enhanced Osteoporosis Therapy
Yufei Zheng,
Zhaowei Zhang,
Zezhou Fu
et al.
Abstract:The discovery of the bone–gut axis linking bone
metabolism
to gut microbiota (GM) dysbiosis has revolutionized our understanding
of managing degenerative skeletal diseases. Targeting GM regulation
has emerged as a promising approach to osteoporosis treatment. Herein,
we develop propolis nanoemulsions (PNEs) with enhanced gastrointestinal
stability and oral bioavailability for GM-based osteoporosis therapy.
Orally administered PNEs exhibit superior antiosteoporosis efficacy
in an ovariectomized (OVX) mouse mode… Show more
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