Oral Retinoid (Ro 10-9359) in Children with Lamellar Ichthyosis, Epidermolytic Hyperkeratosis and Symmetrical Progressive Erythrokeratoderma

Abstract

8 children with lamellar ichthyosis, 1 with epidermolytic hyperkeratosis and 5 with symmetrical progressive erythrokeratoderma were treated with a new aromatic retinoid (Ro 10-9359). Clinical improvement was dramatic. The children acquired an appearance never obtained before with other managements. The treatment had to be maintained to prevent recurrence. The tolerance to the drug was good. The side-effects were minimal and tended to disappear after several months of treatment. Our results suggest that because of its efficacy, good tolerance and easy administration, the oral retinoid Ro 10-9359 is at present the treatment of choice for the great ichthyotic disorders of children.

Two Years’ Experience with Tigason Treatment of Pustulosis palmo-plantaris and Eczema keratoticum manuum

“…Judging from the description the case must have been of the hereditary type. Similar communications have been published by Fritsch et al [4] in 1978, by Pehamberger et al [6] in 1980 and, also in 1980, by Tamaya et al [8]. Apart from these reports, the treat ment of EKM does not seem to have been mentioned in the available literature.…”

Generalized Pustular Psoriasis in a Child

“…It has already been administered to children for a variety of skin disorders. It does not in terfere with growth rate and no serious side effects have been reported [12,14]. Further, it has been established in adults that etreti nate is very effective in controlling GPP [10].…”

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“…Although there is no cure for ichthyosis, retinoids have shown some beneficial effects. Retinoids have shown positive effects in treating various keratinization disorders but due Hypervitaminosis, a syndrome caused by systemic retinoids, and its use have been limited [26][27][28] .…”