Oral SARS‐CoV‐2 reduction by local treatment: A plasma technology application?

Woedtke, Thomas von; Gabriel, Gülşah; Schaible, Ulrich E.; Bekeschus, Sander

doi:10.1002/ppap.202200196

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…Since the PLC seems to be one of the parameters suitable for assessing reproducibility, it is highly relevant whether measurements and treatments were performed in conductive or non-conductive mode. Moreover, it is already known that the different modes have a great influence on the species yield as well as on the biological effect of a treatment [24,41], underscoring the importance of these modes and even more relevant for localized, comparable treatments [15].…”

Section: Discussionmentioning

confidence: 99%

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Characterization and comparability study of a series of miniaturized neon plasma jets

Jablonowski,

Hoffmann,

Bansemer

et al. 2024

J. Phys. D: Appl. Phys.

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During the development of new therapeutic devices, comprehensive experimental investigations are necessary in all phases of the process. This requires the provision of device prototypes with reproducible and comparable operating parameters. In the current study, such miniature neon plasma jet prototypes designated for medical applications have been manufactured, characterized, and compared. The multi-parametric characterization included measurements of energy, power, temperature, leakage current, effluent length, and relative as well as absolute radiation. The dissipated electrical power and the optical emission in the UV range were identified as parameters indicating definable tolerances to sort out a device with inadequate species output. A liquid phase model was used to investigate reactive species deposition into simple matrices. Based on these investigations, a quality control procedure for manufacturing new device series is proposed. In conclusion, our findings suggest a test concept of achieving reproducible and comparable plasma device characterization as a putative quality control measure for lab-scale plasma source production.

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Section: Discussionmentioning

confidence: 99%

“…As it has the advantage of being operable in cavities and is miniaturized, it is potentially suitable for application in the upper respiratory tract for, e.g. antiviral and antimicrobial treatments [15].…”

Section: Introductionmentioning

confidence: 99%

Characterization and comparability study of a series of miniaturized neon plasma jets

Jablonowski,

Hoffmann,

Bansemer

et al. 2024

J. Phys. D: Appl. Phys.

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“…Plasma can also be used to directly manufacture biologically active solutions, and recent years have seen widespread investigation of plasma-activated water in the treatment of bacterial [117][118][119], fungal and viral infections [120,121]. Changes in plasma gas composition [117,119], plasma settings [118] or plasma sources [122] can dramatically alter the composition of the treated liquid, and this can give rise to changes in the physical properties of the activated liquid, which may in turn impact performance [123,124].…”

Section: Interactions Of Plasma With Liquidsmentioning

confidence: 99%

Recent Developments in the Use of Plasma in Medical Applications

O’Neill,

Bourke

2024

Plasma

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A detailed review of the scientific literature was undertaken to examine the most recent developments in plasma processing in the field of medicine. The first part of the review includes a detailed breakdown of the different types of coatings that can be applied onto medical devices using plasma, with a specific focus on antimicrobial surfaces. The developments in plasma-deposited biocompatibles, drug delivery and adhesive coatings in 2023 are described, and specific applications in additive manufacturing are highlighted. The use of plasma and plasma-activated liquids as standalone therapeutics continues to evolve, and pertinent advances in this field are described. In addition, the combination of plasma medicine with conventional pharmaceutical interventions is reviewed, and key emerging trends are highlighted, including the use of plasma to enhance drug delivery directly into tissue. The potential synergies between plasma medicine and chemotherapeutics for oncology and infection treatment are a growing area, and recent advancements are noted. Finally, the use of plasma to control excess antibiotics and to intentionally degrade such materials in waste streams is described.

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Characterization of Sputter-Coated Polyethylene Naphthalate-Foil as Novel Flexible Surface DBD Plasma Source

et al. 2023

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Plasma medicine demands for very specific plasma source configurations. Beside gasflow-driven jet arrays, dielectrical barrier discharges (DBDs) are commonly used to generate ambient air plasma at room temperature for decontamination. There, electrode and dielectric material limit its use in application. Especially, the decontamination of difficult, uneven, or edged surface geometries with DBDs can be rather challenging. Therefore, flexible polyethylene naphthalate-foil with a thickness of 250 μm, which was covered with electrode material by ion-beam sputtering, is characterized regarding its electrical and bactericidal performance for different power and electrode thickness configurations. Operating temperature, ozone production capability, and plasma parameters (electron temperature and density as well as vibrational temperature of N2) were used as characterization parameters. As electrode material, palladium sputtered with a thickness of 110 nm showed the best results of the tested materials. With operation parameters of 3 kHz and 5.5-6.0 kVpp for ozone and 5 kHz and 8.5 kVpp for nitrogen mode log reductions of up to 6.7 (nitrogen mode) and 5.3 (ozone mode), respectively, and D values of 1 min were accomplished for Escherichia coli.

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Oral SARS‐CoV‐2 reduction by local treatment: A plasma technology application?

Cited by 4 publications

References 66 publications

Characterization and comparability study of a series of miniaturized neon plasma jets

Characterization and comparability study of a series of miniaturized neon plasma jets

Recent Developments in the Use of Plasma in Medical Applications

Characterization of Sputter-Coated Polyethylene Naphthalate-Foil as Novel Flexible Surface DBD Plasma Source

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