Oral Signs of Nutritional Disease

Shoshin beriberi in a patient with oral and cutaneous graft-versus-host disease

“…Thiamine (vitamin B1) deficiency affects multiple organ systems and may present with waxy edematous skin, vesicular oral eruptions, oral ulcerations, oral hyperesthesia, burning tongue, fatigue, nausea, vomiting, abdominal pain, anorexia, sensory or motor neuropathies, Korsakoff amnestic-confabulatory syndrome, Wernicke encephalopathy, or beriberi. [1][2][3][4] Shoshin beriberi is a fulminant form of cardiac beriberi that features rapidly progressive heart failure and distributive shock. 1 Hematopoietic cell transplant patients are at increased risk for nutritional deficiencies caused by graft-versus-host disease, comorbid renal dysfunction, and cytotoxic conditioning regimens.…”