“…We read with great interest a review article entitled “Oral soft tissue biopsy surgery: Current principles and key tissue stabilization techniques” newly published in this journal by Jeng et al. 1 They well elucidated the general principles of oral biopsy and key tissue stabilization techniques. Through this article, clinicians, especially general dentists, will obtain more understanding of diagnosis accuracy and tissue stabilization methods of oral soft tissue biopsy.…”
mentioning
confidence: 99%
“…Nonetheless, excisional biopsy should be avoided if a frank carcinoma was the possible concern, to preserve the border of malignant lesion for a definite extirpation by the oral and maxillofacial surgeon. 1 Figure 1 Clinical impression of (A) a microcarcinoma within an oral premalignant lesion and (B) an oral squamous cell carcinoma de novo which was a frank carcinoma. Tissue stabilization using the two retraction sutures simultaneously when performing the surgical excision of (C, D, E) a tongue lesion and (F) a lip lesion.…”
mentioning
confidence: 99%
“…mentioned that the agent of local anesthesia should not be injected directly into the lesional tissues, mainly because this injection may result in separation of connective tissue bundles particularly for the immune mediated mucocutaneous disorders. 1 For oral premalignant and malignant lesions, the agent could be injected into the normal tissue adjacent to the lesions. Notably, currently available preclinical studies suggest that local anesthetics such as lidocaine can suppress proliferation of several cancer cell types and increase natural killer (NK) cell activity.…”
mentioning
confidence: 99%
“…Thus, tissue stabilization increased the accuracy of incision, facilitated suturing, and shortened the duration of the biopsy procedure. 1 More importantly, this technique could decrease or avoid stimulation to the lesion and fitted the principles of an-neoplasia surgical operation and an-touch radical excision of the carcinoma.…”
mentioning
confidence: 99%
“…Collectively, we commended the general principles of oral biopsy and key tissue stabilization techniques described by Jeng and his colleagues. 1 The current paper can consummate some important aspects for biopsies of the oral premalignant and malignant lesions, including different clinical behaviors of microcarcinoma within an OPL and a frank OSCC, local anesthesia and wound closure of incisional biopsy aspects, and tissue stabilization using the two retraction sutures simultaneously.…”
“…We read with great interest a review article entitled “Oral soft tissue biopsy surgery: Current principles and key tissue stabilization techniques” newly published in this journal by Jeng et al. 1 They well elucidated the general principles of oral biopsy and key tissue stabilization techniques. Through this article, clinicians, especially general dentists, will obtain more understanding of diagnosis accuracy and tissue stabilization methods of oral soft tissue biopsy.…”
mentioning
confidence: 99%
“…Nonetheless, excisional biopsy should be avoided if a frank carcinoma was the possible concern, to preserve the border of malignant lesion for a definite extirpation by the oral and maxillofacial surgeon. 1 Figure 1 Clinical impression of (A) a microcarcinoma within an oral premalignant lesion and (B) an oral squamous cell carcinoma de novo which was a frank carcinoma. Tissue stabilization using the two retraction sutures simultaneously when performing the surgical excision of (C, D, E) a tongue lesion and (F) a lip lesion.…”
mentioning
confidence: 99%
“…mentioned that the agent of local anesthesia should not be injected directly into the lesional tissues, mainly because this injection may result in separation of connective tissue bundles particularly for the immune mediated mucocutaneous disorders. 1 For oral premalignant and malignant lesions, the agent could be injected into the normal tissue adjacent to the lesions. Notably, currently available preclinical studies suggest that local anesthetics such as lidocaine can suppress proliferation of several cancer cell types and increase natural killer (NK) cell activity.…”
mentioning
confidence: 99%
“…Thus, tissue stabilization increased the accuracy of incision, facilitated suturing, and shortened the duration of the biopsy procedure. 1 More importantly, this technique could decrease or avoid stimulation to the lesion and fitted the principles of an-neoplasia surgical operation and an-touch radical excision of the carcinoma.…”
mentioning
confidence: 99%
“…Collectively, we commended the general principles of oral biopsy and key tissue stabilization techniques described by Jeng and his colleagues. 1 The current paper can consummate some important aspects for biopsies of the oral premalignant and malignant lesions, including different clinical behaviors of microcarcinoma within an OPL and a frank OSCC, local anesthesia and wound closure of incisional biopsy aspects, and tissue stabilization using the two retraction sutures simultaneously.…”
Labial salivary gland biopsy (LSGB) is one of the specific diagnostic criteria for primary Sjögren's syndrome (pSS). In traditional LSGB, there is no lower lip fixation device, the field of view is unclear due to intraoperative bleeding, and the incision is large, which is unfavourable for healing. The use of auxiliary devices to improve the shortcomings of traditional LSGB technique would be meaningful. Therefore, this case–control study aimed to assess the value of modified LSGB using chalazion forceps as compared with traditional LSGB. After obtaining written informed consent from all participating parents and patients, we randomly assigned 217 eligible participants to undergo LSGB using chalazion forceps (n = 125) or traditional LSGB (n = 92). The outcome variables were surgical time, incision length, intraoperative bleeding, pain score at 24 h after surgery, incision healing status at 7 days after surgery, gland collection, and pathological results. The final diagnostic results of the two surgical methods were compared, and the match rates between the pathological results and the final clinical diagnoses were compared between the two groups. The data were analysed using parametric and nonparametric tests. Compared with the traditional group, the modified group had a smaller incision, shorter operative time, less blood loss, lower 24 h pain score, and better Grade A incision healing at 7 days after surgery (
p
< 0.01). There was no statistically significant difference between the patients in the two surgical-method groups in terms of the positive biopsy results and the final diagnosis based on expert opinions (
p
> 0.05). By multivariable regression analysis, only a focus score (FS) of ≥ 1 (
p
< 0.01), dry eye disease (
p
< 0.05) and anti-nuclear antibodies (ANA) titre ≥ 1:320 (
p
< 0.05) were correlated with the diagnosis of pSS. The positive biopsy results of patients in the different surgical-method groups had a biopsy accuracy of > 80.0% for the diagnosis of pSS. The positive biopsy results in the different surgical-method groups were consistent with the expert opinions and the 2016 ACR-EULAR primary SS classification criteria. The modified LSGB using an auxiliary chalazion forceps offers a good safety with a small incision, shorter operative time, less bleeding, reduced pain and a low incidence of postoperative complications.The match rate of LSGB pathological results of the proposed surgical procedure with the final diagnosis of pSS is high.
Background/Objectives: Oral cancer (OC) is a disease with poor prognosis mainly due to late diagnosis. There is considerable interest in the use and development of rapid, point of care (POC) non-invasive methods that can accelerate the diagnostic process. Bioimpedance (BI) is resistance to the passage of electric currents through tissue that reflects structural changes in the tissue. The aim of this study was to determine the spectrum of BI values in patients with oral cancer, to compare them with other oral lesions and healthy controls, and to determine the diagnostic value of the BI-based method for diagnosis of OC. Methods: Ninety-three participants divided into three groups participated in this study. The first group (31 participants) consisted of patients with histologically confirmed OC, the second group (31 participants) consisted of patients with an active reticular form of oral lichen planus (positive controls; OLP) and the third group (31 participants) consisted of healthy controls. In OC and OLP patients, BI was measured at three points (non-ulcerated lesional mucosa, clinically unaffected perilesional mucosa and unaffected mucosa on the contralateral side). In healthy controls, BI was measured on a healthy mucosa in the corresponding anatomical region. Measurements were performed at nine frequencies (1, 2, 5, 7, 10, 20, 70 and 100 kHz). Results: In OC patients, BI values in the lesion were significantly lower than BI values in clinically intact perilesional mucosa and the unaffected contralateral side at all frequencies. Furthermore, BI values of the clinically intact perilesional mucosa were significantly lower than the BI values of the healthy contralateral mucosa at frequencies of 1 kHz, 2 kHz, 5 kHz, 7 kHz and 10 kHz. Patients with OC had significantly lower BI values compared to patients with OLP and individuals with healthy oral mucosa at all frequencies. Conclusions: This study demonstrated the very good to excellent ability of this method to detect OC lesions, which needs to be confirmed by further studies on a larger number of participants.
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