Oral solution of fructose promotes SREBP-1c high-expression in the hypothalamus of Wistar rats

Batista, Leandro Oliveira; Ramos, Viviane Wagner; Fernández, Mariana Rosas; Vilca, Carlos Concha; Albuquerque, Kelse Tibau de

doi:10.1080/1028415x.2018.1427659

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…The results show that 30% fructose solution causes a significant increase in BW. It was reported that 20% fructose solution did not cause change in both BW and biochemical parameters (2). In this study, as well as BW, liver weights were similar in F15 and F60.…”

Section: Discussionsupporting

confidence: 63%

“…In a study, SREBP-1c and ACACA gene expression increased in the hypothalamus with 20% fructose consumption, while FAS was downregulated (2). In addition, it was reported that food intake was suppressed through FAS inhibitors in the hypothalamus, preventing body weight gain (2). With this study, lipogenic genes activity has been determined that strongly changed with the fructose consumption in liver.…”

Section: Discussionmentioning

confidence: 71%

“…Recently, with the consumption of fructose the activity of lipogenic genes in other tissues has been investigated as well. In a study, SREBP-1c and ACACA gene expression increased in the hypothalamus with 20% fructose consumption, while FAS was downregulated (2). In addition, it was reported that food intake was suppressed through FAS inhibitors in the hypothalamus, preventing body weight gain (2).…”

Section: Discussionmentioning

confidence: 99%

“…However, molecular studies on the rate of fructose in diets are limited. In general, variable fructose solutions (mostly 10-30%) are used for the investigation of metabolic effects of fructose on laboratory animals (2,7). In this study, besides standard chow, consumption of 15%, 30%, and 60% concentration fructose solutions for 10 weeks were examined at the biochemical and histopathological levels.…”

Section: Introductionmentioning

confidence: 99%

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Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats

Özkan

Kutlu

YAKIN

et al. 2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The aim of this study was to investigate the lipogenic and inflammatory effects of low and high percentage fructose solutions in rats. Wistar albino rats were fed with fructose solutions for 10 weeks. Groups were as follows: Cont (Control), F15 2 (Fructose 15%), F30 (Fructose 30%), F60 (Fructose 60%). Body weights of rats were weekly measured. Also, lipogenic and inflammatory genes expression levels, biochemical parameters and histopathological changes in liver were investigated. After 10 weeks, it was observed that the animals in the F60 were the heaviest, while the animals in the F30 were the lightest. In all experimental groups, triglycerides were significantly higher than those of Cont (P<0.05). In the F30 and F60, TNFα, IL-6 and IL-1β were upregulated in liver compared to Cont (P<0.05). In addition, SREBP-1c, ChREBP, FAS, ACACA and SCD-1 were upregulated in all fructose feeding groups compared to Cont (P<0.05). The livers of rats in the F30 and F60 groups had degenerative changes and steatosis. The most detrimental effects of fructose were observed in F60. The concentration of the fructose was found to be a very important factor for maintaining normal liver physiology at the molecular levels.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats

Özkan

Kutlu

YAKIN

et al. 2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…It was thought that NRF-2 acts with COX-2 gene expression level up to a certain concentration of consumed fructose in drinking water, but this effect disappears when the concentration of consumed fructose increases. It was stated that the reaction to fructose in metabolism varies according to the amount and duration of exposure (1,4,6). There was no significant relationship between MDA level and COX-2, NRF-2 gene expression other than the 2 above mentioned.…”

Section: Discussionmentioning

confidence: 99%

The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes

Özkan

Kutlu

2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The use of fructose as converted sugar in the food industry is quite common. Steatosis and degeneration occur due to the use of fructose in the liver where sugar is primarily metabolized. However, there is not enough information about the level of MDA and the expression levels of COX-2 and NRF-2 in the liver with low and high fructose consumption. The aim of the study is to evaluate the effect of different concentrations of fructose solutions on the expression levels of COX-2 and NRF-2 genes as well as MDA levels in the livers of rats. In this study, the effects of different fructose solution [F15; (15%) F30; (30%) and F60; (60%)] consumption for 10 weeks in rats on the MDA levels also COX-2 and NRF-2 genes expression levels in the liver were investigated. The MDA level and COX-2 gene expression level in F60 group were higher than the control and other groups (P<0.01). These findings suggest that MDA elevation in the liver may be due to inflammation. However, no change was observed in total NRF-2 gene expression. Also, a positive correlation was found between levels of COX-2 and NRF-2 expressions in F30 (0.965; P<0.01). These findings may be attributed to inflammation of liver. This may have been due to an increase in nuclear formation of NRF-2. As a result, the use of high concentration fructose solution has been found to increase the level of MDA in the liver due to inflammation.

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Can fructose influence the development of obesity mediated through hypothalamic alterations?

Cargnin-Carvalho

Mello

Bressan

et al. 2020

J of Neuroscience Research

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Epidemiological data from the last decades point to an exponential growth in the number of obese people. Different behavioral factors, mainly associated with food consumption, appear to contribute significantly to its development. Concomitant with increased obesity rates, an increase in the consumption of fructose has been observed; therefore, fructose consumption has been implicated as an important obesogenic factor. However, changes in brain activity due to fructose consumption are possible, especially in relation to hypothalamic satiety mechanisms. In addition, the obese state may provide an environment of chronic inflammation and further contribute to the discontinuation of satiety mechanisms in the hypothalamus. We briefly review the intrinsic alterations to the increased adipose tissue, its connections with the hypothalamus in the control of energy signaling mechanisms and, consequently, the participation of fructose as a co‐adjuvant or trigger. Presenting the current context with clinical trials involving human and animal studies, we seek to contribute to a better understanding of the role of fructose in the progression of obesity.

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Oral solution of fructose promotes SREBP-1c high-expression in the hypothalamus of Wistar rats

Abstract: Dietary fructose can change important lipogenic and inflammatory factors in the hypothalamus of rats and it leads to regulation of transcription factors before changes in body mass are evident.

Cited by 10 publications

References 25 publications

Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats

Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats

The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes

Can fructose influence the development of obesity mediated through hypothalamic alterations?

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