Oral Squamous Cell Carcinoma Arising Around Osseointegrated Dental Implants

Javed, Fawad; Al‐Askar, Mansour; Qayyum, Faisal; Wang, Hom Lay; Al‐Hezaimi, Khalid

doi:10.1097/id.0b013e31824cde85

Cited by 17 publications

(17 citation statements)

References 31 publications

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“…Although peri-implant malignancy has not been identified in the present study, there are over 35 reported cases of peri-implant malignancy in the literature (mainly primary malignancy), which in the majority of cases also mimic PI. [8][9][10][11]33 Delayed diagnosis in these cases may have more severe implications than just implant loss, stressing the need for microscopic evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…There are more than 18 articles in the literature describing peri-implant malignancy, [8][9][10][11] 12 reported cases of peri-implant GCG, [12][13][14][15][16][17][18][19] and only two cases of PG around implants. 20,21 The majority of these lesions exhibit clinical characteristics which are consistent with PI; however, they do not behave like conventional PI and would not respond as expected to treatment modalities for conventional PI (debridement, improved hygiene, chlorhexidine rinses, short-term antibiotics, etc.)…”

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confidence: 99%

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The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis

Kaplan

Hirshberg

Shlomi

et al. 2013

Clin Implant Dent Rel Res

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There were no clinical features which could distinguish PI with simple inflammation from potentially destructive lesions mimicking PI, such as GCG, PG, and actinomycosis. However, to control GCG and PG surgical procedures would be recommended, actinomycosis would indicate specific antibiotics, whereas in nonspecific inflammation, these measures may not be indicated. The results of the present study provide evidence for the importance of early microscopic examination of lesions presenting clinically as peri-implantitis, a step toward more accurate diagnosis and improved treatment of PI and lesions mimicking PI.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis

Kaplan

Hirshberg

Shlomi

et al. 2013

Clin Implant Dent Rel Res

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“…This case and others 1,3,6,8‐10,12,13 indicate that it is important for periodic oral and radiographic examinations to be performed after implant placement. Although extremely rare, neoplasia must be considered in the evaluation of peri‐implant pathology.…”

Section: Discussionmentioning

confidence: 65%

“…The growing number of case reports of SCC in the vicinity of dental implants indicate that SCC should be considered in the differential diagnosis of peri‐implant pathology 1,3,6,7,9,11‐13 …”

Section: Discussionmentioning

confidence: 99%

“…Most reported cases have occurred in patients with other known risk factors for development of oral SCC (OSCC), such as a history of tobacco use, alcohol intake, or a premalignant oral condition. Of these, most presented with surface mucosal alterations at the site of the SCC, including erythema, ulcerations, or granular hyperplastic changes 1,8‐12 …”

Section: Introductionmentioning

confidence: 99%

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Oral Squamous Cell Carcinoma Mimicking Peri‐Implantitis

Chainani‐Wu

Chang

Sim

et al. 2016

Clin Adv Periodontics

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Introduction: Peri‐implantitis is inflammation and alveolar bone loss around a dental implant. Published case reports have described squamous cell carcinoma (SCC) development around dental implants. Case Presentation: A 60‐year‐old female presented with two small fistulas on the alveolar ridge of missing tooth #18. The mucosa around the fistulas appeared normal otherwise, with no hyperplasia, erythema, or keratotic changes. The patient had a 14‐year history of recurrent erythroleukoplakia (with microscopic dysplasia) on the left tongue that had been managed by surgical removal (scalpel and carbon dioxide laser), biopsies, and close follow‐up. She had no other medical conditions. She reported that she had an implant placed to replace tooth #18 4 years ago that had been removed without flap reflection, curettage, or biopsy 1 year previously as a result of peri‐implantitis. Periapical radiographs showed that the peri‐implant radiolucency in the region of tooth #18 was unchanged in dimensions from the time of implant removal 1 year ago. Curettage and biopsy of the area were performed and showed the presence of a well‐differentiated SCC. Conclusions: This is a case of peri‐implant SCC development in a patient at high risk for oral SCC. The carcinoma was present within the alveolar defect in the area of a failed implant that had been removed 1 year previously. The overlying surface mucosa did not show the clinical changes typically seen in carcinoma. This case and others demonstrate the importance of periodic oral and radiographic examination after implant placement. Although rare, neoplasia must be considered in the evaluation of peri‐implant pathology.

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Histopathological Features of Secondary Squamous Cell Carcinoma Around a Dental Implant in the Mandible After Chemoradiotherapy: A Case Report With a Clinicopathological Review

Nariai

Kanno

Sekine

2016

Journal of Oral and Maxillofacial Surgery

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Oral Squamous Cell Carcinoma Arising Around Osseointegrated Dental Implants

Abstract: OSCC is more likely to arise around osseointegrated DI in patients with a previous history of cancer. However, the role of other factors including tobacco and alcohol usage cannot be disregarded.

Cited by 17 publications

References 31 publications

The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis

The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis

Oral Squamous Cell Carcinoma Mimicking Peri‐Implantitis

Histopathological Features of Secondary Squamous Cell Carcinoma Around a Dental Implant in the Mandible After Chemoradiotherapy: A Case Report With a Clinicopathological Review

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