Oral squamous cell carcinoma in a 7-year-old Brazilian boy

Tongue carcinoma as a secondary malignancy in a 17‐year‐old leukemia survivor: A case report

“…described a well‐differentiated gingival SCC in a 7‐year‐old Brazilian boy. Clinically, it was an ulcerated nodular lesion in the left maxilla that caused dental mobility 16 . Therefore, the clinical manifestations of SCC in young patients do not show different characteristics from those of older patients.…”

“…Some authors considered young patients with SCC those under 45 years of age, while other authors used ages under 20 or 30 years as a reference of young patients 12–14 . Approximately 1–6% of SCC cases are diagnosed in patients under 40 years of age, and only a small sample of this subgroup (fewer than 2%) affected pediatric patients (≤19 years), thereby making oral SCC in this age group an extremely rare entity 14–17 . A study conducted at a tertiary referral center in pediatric oncology in Brazil reported the frequency of pediatric oral and maxillofacial cancer over a period of 30 years, and found no cases of SCC as a primary neoplasm 18 …”

“…Fanconi's anemia, Li Fraumeni syndrome, KID syndrome, and immunosuppression may increase the risk of malignant epithelial tumors of the head and neck 17,25,26 . In the pediatric population, oral SCC can be related to immunosuppressive therapy, viral infection, malnourishment, passive smoking, and late complications of chemo/radiotherapy 16,26,27 . These factors may be present as single factors, but in combination may play a more compelling role in the early development of oral SCC.…”

“…[12][13][14] Approximately 1-6% of SCC cases are diagnosed in patients under 40 years of age, and only a small sample of this subgroup (fewer than 2%) affected pediatric patients (≤19 years), thereby making oral SCC in this age group an extremely rare entity. [14][15][16][17] A study conducted at a tertiary referral center in pediatric oncology in Brazil reported the frequency of pediatric oral and maxillofacial cancer over a period of 30 years, and found no cases of SCC as a primary neoplasm. 18 Oral SCC may present clinically as leukoplakia or erythroplakia, but is mainly seen as indurated ulcers or lumps, granular ulcers with tissue infiltration and raised exophytic margins, or a nonhealing extraction socket.…”

Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma

“…In a recent study, patients with OSSC who died because of metastasis were younger than those who died from locoregional tumor invasion (Jerjes et al ). Several studies have shown that young patients with OSCC have a more advanced stage and a poorer prognosis than older patients (Garavello et al, 2007;Jerjes et al ;Soudry et al, 2010;Ribeiro et al ).…”