Oral squamous cell carcinoma in a South African sample: Race/ethnicity, age, gender, and degree of histopathological differentiation

Khammissa, R A G; Meer, Shabnum; Lemmer, J

doi:10.4103/0973-1482.138100

Cited by 21 publications

(16 citation statements)

References 41 publications

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“…Our data's gender distribution was comparable with the Pakistani and African population [13,17]; however, the male predilection was observed up to 4.3:1 in multicenter studies involving larger sample data [12,16]. These findings are in accordance with multiple studies conducted to associate the age [13][14][15][16] and gender factors [15,[17][18][19][20] with the increasing risk of developing OC.…”

Section: Socio-demographic Featuressupporting

confidence: 90%

“…In Malaysia and Indonesia, betel quid chewing habit has been primarily replaced with smoking since early to mid-1990s [23]. The second most common tumor site within the oral cavity included parotid and submandibular glands, which was also found to be in opposition to several other studies [12,[18][19][20].…”

Section: Socio-demographic Featuresmentioning

confidence: 94%

“…The majority of patients presenting at the T4 stage were not surgically operated, explaining the high incidence of cases receiving no treatment. We identified that different studies described their results based on different classification systems, histopathology [15], nature of the tumor (benign or malignant) [14], site of the tumor [18], grading of differentiation [13] and involved region [5,12].…”

Section: Socio-demographic Featuresmentioning

confidence: 99%

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Association of Socio-Demographic and Clinicopathological Risk Factors with Oral Cancers: A 19-Year Retrospective Study

Ahmad

Arshad

Jehangir

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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Section: Socio-demographic Featuressupporting

confidence: 90%

Section: Socio-demographic Featuresmentioning

confidence: 94%

Section: Socio-demographic Featuresmentioning

confidence: 99%

See 1 more Smart Citation

Association of Socio-Demographic and Clinicopathological Risk Factors with Oral Cancers: A 19-Year Retrospective Study

Ahmad

Arshad

Jehangir

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…This suggests that estrogen deficiency may play a role in the pathogenesis of OSCC in some women. [ 22 ] Due to the increase in the incidence of oral cancer in females, in our study, we found the higher metastatic potential was associated with high-grade tumor buds, Type V ITF pattern, and poorly differentiated OSCC.…”

Section: Discussionmentioning

confidence: 59%

Development of clinico-histopathological predictive model for the assessment of metastatic risk of oral squamous cell carcinoma

Sowmya¹,

Rao²,

Prasad³

2020

J Carcinog

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CONTEXT: Oral cancer metastasis is the leading cause of death globally. The decision-making on the mode of surgical treatment in clinically negative lymph nodes is challenging. AIM: The aim of this study was to develop a predictive model using clinical and histopathologic parameters that may help in the assessment of the metastatic risk of oral squamous cell carcinoma (OSCC). SETTINGS AND DESIGN: Clinical data of histopathologically confirmed primary OSCC from 2014 to 2017 were retrieved from the archives. Histopathological parameters for metastasis that were considered for evaluation in the study were tumor buds, cytoplasmic pseudofragments, tumor grade, depth of invasion, invasive tumor front (ITF) pattern, and lymphovascular invasion (LVI). METHODS: Hematoxylin and eosin and pan-cytokeratin immunostained sections of metastatic and nonmetastatic OSCC were assessed for histopathological features and correlated with clinical parameters. STATISTICAL ANALYSIS USED: SPSS software (Statistical Package for Social Sciences for Windows, Version 22.0 (2013) (IBM Corp., Armonk, NY, USA)) was used for the statistical analysis. Pearson's Chi-square test was done to assess the grades of histopathological and clinical parameters between the study groups. Univariate analysis was performed to develop a clinicopathologic predictive model. RESULTS: The clinicopathologic model signifies that OSCC with clinical Stage IV, high grades of tumor buds and cytoplasmic pseudofragments, Type V ITF pattern, positive LVI, deeply invasive tumors, and poorly differentiated grades of OSCC have a high risk of developing nodal metastasis. These parameters may be used as early predictors for metastasis of OSCC both in incisional and excisional biopsy specimens. CONCLUSIONS: The proposed predictive model is simple, cost-effective, and user-friendly for the early assessment of nodal metastatic risk in clinically negative lymph nodes.

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“…Differences between genders regarding some anatomical variations ( 1 ), and the incidence and behavior of diseases are well documented in medicine ( 2 – 5 ) as well as in dentistry the differences between males and females regarding root morphology ( 6 , 7 ) and the association with some diseases were also reported ( 8 , 9 ). In the dental literature, many anatomical studies addressed different variations in root canal morphology according to ethnic background ( 10 – 18 ), while, scarce and inconclusive information are available regarding gender impact on teeth morphology ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Root and Root Canal Morphology Differences Between Genders: A Comprehensive in-vivo CBCT Study in a Saudi Population

Mashyakhy

Gambarini

2019

Acta Stomatol Croat

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ObjectivesTo comprehensively explore the differences of all maxillary and mandibular permanent teeth in relation to number of roots, number of root canals, and root canal configuration between both genders in a Saudi Arabian population.MethodsThis retrospective radiographic study comprised 208 subjects (48% males and 52% females) with a mean age 28.74±9.56 years. The CBCT images of the recruited subjects were evaluated for all permanent teeth. A careful examination was obtained by optimal visualization using all the software features. The data were analyzed using SPSS software program. Cohen’s Kappa test was used for reliability and the Chi-squared test of association was used for the differences between both genders in relation to the study variables. A P-value < 0.05 was considered significant.ResultsA total of 5254 maxillary and mandibular permanent teeth were evaluated. In relation to number of roots, there were no significant differences between both genders for all maxillary and mandibular teeth together (P= 0.064) as well as for maxillary and mandibular teeth separately (P= 0.315 and P= 0.100, respectively). A significant difference was found between males and females in relation to the number of canals of maxillary teeth (P= 0.014). For mandibular teeth, the significant level of difference was at the cut-off point (P= 0.050). For all maxillary and mandibular teeth together, the distribution among both genders was not significant (P= 0.082). The difference between both genders with regard to canal configuration of maxillary roots was highly statistically significant (P< 0.001). For mandibular teeth, the difference between males and females in relation canal configuration of anterior and premolar teeth was significant (P= 0.016) while, the difference was not significant when related to mesial roots of 1st and 2nd molars (P= 0.205). However, the difference was highly significant when related to distal roots of 1st and 2nd molars (P< 0.001).ConclusionNo significant differences between both genders in relation to number of roots were found. Regarding the number of canals, significant differences were found only in three groups out of 14 groups of teeth with females who had a smaller number of canals than males. For canal configuration, two groups of maxillary teeth and three groups of mandibular teeth showed statistically significant differences between both genders.

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Oral squamous cell carcinoma in a South African sample: Race/ethnicity, age, gender, and degree of histopathological differentiation

Abstract: OSCC was diagnosed at a younger age in black than in white persons; the proportion of black males in the black population group was greater than that of white males in the white population group; and the proportion of SCC of the lips was higher in younger than in older persons.

Cited by 21 publications

References 41 publications

Association of Socio-Demographic and Clinicopathological Risk Factors with Oral Cancers: A 19-Year Retrospective Study

Association of Socio-Demographic and Clinicopathological Risk Factors with Oral Cancers: A 19-Year Retrospective Study

Development of clinico-histopathological predictive model for the assessment of metastatic risk of oral squamous cell carcinoma

Root and Root Canal Morphology Differences Between Genders: A Comprehensive in-vivo CBCT Study in a Saudi Population

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