Oral squamous cell carcinoma overview

Scully, Crispian; Bagán, José

doi:10.1016/j.oraloncology.2009.01.004

Cited by 413 publications

(395 citation statements)

References 67 publications

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“…4 Unlike the associa-Braz Oral Res., (São Paulo) 2014;28(Spec Iss 1): [1][2][3][4][5][6][7][8] tion between sunlight and skin cancer, the association between sunlight and lip cancer is unknown to most, contributing to people's negligence towards their lips. 8 The dentists surveyed in this study believed that smokers are at the highest risk of oral cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions that best represent this group are erythroplakias, non-homogeneous leukoplakia, and actinic cheilosis, with malignant transformation rates of 85%, 30%, and 30%, respectively. 2 In 2012, the Instituto Nacional de Câncer -INCA (National Cancer Institute) estimated 14,170 new cases of oral cancer in Brazil, corDeclaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

Section: Introductionmentioning

confidence: 99%

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Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

et al. 2014

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The aim of this study is to share the experience of implementing a network for the diagnosis of oral cancer by integrating primary, secondary, and tertiary oral health care centers and identifying the possible weaknesses of the process. The study also investigated the risks of exposure to the main risk factors for oral and lip cancer and their most common potentially malignant lesions (PML). A quantitative cross-sectional study was conducted in two different regions, with patients seen at a primary health care facility from August 2010 to July 2011. Patients with oral lesions were referred to dental specialty centers for biopsy. Patients with PML were treated in dental specialty centers, and patients with squamous cell carcinoma (SCC) were referred to tertiary health care facilities. The dentists' knowledge of PML and SCC was assessed by an objective questionnaire. A total of 3,965 individuals were examined, 296 lesions were found, and 73 biopsies were performed, of which 13.7% were diagnosed as PML and 9.6% as SCC. Tobacco use and sunlight exposure were associated with SCC (85.7%) and PML (80%), respectively. In total, 55 dentists were assessed. The lesions most commonly recognized as PML were leukoplakia (74%), erythroplakia (57%), and actinic cheilosis (56%). Most dentists (74%) felt incapable of performing biopsies, most likely because of an anxiety towards oral cancer, and 57% had never performed one. The integration of primary and secondary health care enables the diagnosis of PML and SCC and establishes a diagnosis network. However, the inability of most primary care dentists to identify PML and perform biopsies is a weakness of the diagnostic process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

et al. 2014

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“…The majority of cases are well advanced before diagnosis (Silverman et al, 2010) as a result of a late attendance by patients and also inability of dentists and other physicians in early detection of suspicious lesions (Scully et al, 2009). Therefore, early detection through identifying patients with high-risk behaviors is currently the greatest opportunity to decrease the mortality and morbidity rate associated with oral cancers (Saleh et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Attitude and Practices Among Dentists and Senior Dental Students in Iran Toward Tobacco Cessation as an Effort to Prevent Oral Cancer

Razavi

Zolfaghari²,

Doost³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Oral health professionals are responsible in Iran for providing a brief tobacco cessation program to smoker patients. The aim of this study was to assess Iranian dental student and dentist practice, knowledge and attitudes toward smoking cessation programs. Materials and Methods: A valid and reliable self-administered questionnaire was designed and distributed to 150 dentists working in Isfahan-Iran and 60 dental students. Some questions were developed based on the expected 5A tobacco cessation protocol. Statements on attitudes focused on professional responsibility towards smoking cessation and its effectiveness. Chi-square, ANOVA, and t test were used for statistical analysis. Results: The cessation program in dental settings covers a small group of patients (18%). Some 69.1% (n=96) of dentists reported asking their patients about tobacco use, 64% (n=83) advising their patients to quit, 33.8% (n=47) assessing their patients willingness to quit and 20% (n=28) reported helping their patients in changing their behavior. A far lower percentage reported active involvement in arranging assistance for smokers to quit (4.3%, n=5). Some 22% of students and 26% of dentists disagreed that the tobacco cessation programs should be as part of dentists' professional responsibility and 70% of them were willing to follow the protocol of tobacco cessation for patients. Conclusions: Iranian dentist performance regarding tobacco cessation is weak. Dentists and students indicated their lack of knowledge as the major reason for non-adherence to the protocol. Therefore, planning to encourage dentist to follow the protocol needs continuous educational programs.

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“…Head and Neck Squamous Cell Carcinoma (HNSCC) is the 8th and 13th most common malignancy in the world for males and females, respectively, with a predominance of oral squamous cell carcinomas (OSCC) (Warnakulasuriya, 2009;Scully and Bagan, 2009;Nicole et al, 2010). The highest incidence of OSCC is found inIncreasing experimental evidence supports the CSC model in OSCC, which is in favor of a small proportion of cells with the capability of sustaining tumour formation, tumour growth, self-renewal & differentiation in a tumour type and context dependent manner.…”

Section: Introductionmentioning

confidence: 99%