Oral steroids for preschool children with acute wheeze: a systematic review and meta-analysis

Murphy, J.; King, Charlotte; Kapitein, Berber; Fernandes, Ricardo M; Lilley, Andrew; Messahel, Shrouk; Hawcutt, Daniel B; Sinha, Ian

doi:10.1183/13993003.congress-2019.oa4941

Cited by 2 publications

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“…Lo studio conclude quindi, con un' alta qualità di evidenza, che i corticosteroidi per via orale non dovrebbero essere usati in pronto soccorso in pazienti con broncospasmo in età prescolare. Gli effetti sui pazienti con asma nota o ospedalizzati con malattia severa è incerto [1]. In uno studio randomizzato placebo-controllo Foster et al hanno evidenziato una riduzione dei tempi di osservazione in pronto soccorso (di circa 3 ore) dei bambini di 24-72 mesi con broncospasmo acuto associato a forme infettive virali trattati con prednisolone rispetto al gruppo trattato con placebo.…”

Section: Altri Studi Sull' Argomentounclassified

Migliorare la comunicazione in ambulatorio riduce la prescrizione degli antibiotici per le infezioni respiratorie: i risultati di un RCT

Milano¹

2021

PEQACP

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How does oral cortisone work in acute bronchospasm in preschool age? ARCT with not reassuring results. The 2021 guide of the Global Initiatve for Asthma (GINA) states that the use of oral steroids in preschool children with acute bronchospasm is only recommended in cases of severe exacerbation, however the literature continues to present conflicting results. The Wheeze and Steroids in Preschoolers (WASP) Study, conducted in 3 New Zealand emergency rooms, randomized 477 children aged 24–59 months with acute bronchospasm to receive oral prednisolone for 3 days versus placebo. The respiratory outcomes measured were conflicting: the change in severity score (PRAM) at 24 hours was not different between the 2 groups, while the absolute value of the score at both 4 and 24 hours (secondary outcomes) was significantly lower in the prednisolone group. Hospitalization rate, need for further oral prednisolone treatment, and intravenous drug use were also lower in the prednisolone group. It is debated whether the equivalence design of the study and the margins chosen by the authors for the primary outcome have attenuated the difference between the treatments.

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Section: Altri Studi Sull' Argomentounclassified

Migliorare la comunicazione in ambulatorio riduce la prescrizione degli antibiotici per le infezioni respiratorie: i risultati di un RCT

Milano¹

2021

PEQACP

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“…M urphy et al . [ 23 ] performed a systematic review and meta-analysis on the use of oral corticosteroids (OCS) in preschool children presenting to the emergency department with acute wheeze. Four studies were included and OCS use was not found to reduce the risk of hospitalisation (risk ratio 0.94, 95% CI 0.8–1.12) or length of stay.…”

Section: Paediatric Asthma and Allergymentioning

confidence: 99%

ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

et al. 2020

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Oral steroids for preschool children with acute wheeze: a systematic review and meta-analysis

Cited by 2 publications

References 0 publications

Migliorare la comunicazione in ambulatorio riduce la prescrizione degli antibiotici per le infezioni respiratorie: i risultati di un RCT

Migliorare la comunicazione in ambulatorio riduce la prescrizione degli antibiotici per le infezioni respiratorie: i risultati di un RCT

ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

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