Oral strip technology: Overview and future potential

Dixit, Rahul; Puthli, Shivanand P.

doi:10.1016/j.jconrel.2009.06.014

Cited by 487 publications

(406 citation statements)

References 51 publications

Supporting

Mentioning

385

Contrasting

Unclassified

Order By: Relevance

“…Drug absorption via the buccal mucosa surface and into the systemic circulation is relatively fast (compared to the skin) owing to the highly vascularized structure underneath the mucosal tissues [1,2].…”

Section: Introductionmentioning

confidence: 99%

Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs

Kianfar

Antonijević

Chowdhry

et al. 2013

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Lyophilized muco-adhesive wafers with optimum drug loading for potential buccal delivery have been developed. A freeze-annealing cycle was used to obtain optimized wafers from aqueous gels containing 2% κ-carrageenan (CAR 911), 4% pluronic acid (F127), 4.4% w/w polyethylene glycol with 1.8% w/w paracetamol or 0.8% w/w ibuprofen. Thermogravimetric analysis showed acceptable water content between 0.9 -1.5%. Differential scanning calorimetry and X-ray diffraction showed amorphous conversion for both drugs. Texture analysis showed ideal mechanical and mucoadhesion characteristics whilst both drugs remained stable over six months and drug dissolution at a salivary pH showed gradual release within two hours. The results show the potential of CAR 911 and F127 based wafers for buccal mucosa drug delivery.Keywords: Amorphous, Buccal drug delivery system, Carrageenan, Dissolution characteristics, Lyophilized wafer, (Muco)-adhesion, 3 IntroductionMucosal drug delivery systems have many advantages such as bypassing first pass liver metabolism and avoiding GI enzymatic degradation. Drug absorption via the buccal mucosa surface and into the systemic circulation is relatively fast (compared to the skin) owing to the highly vascularized structure underneath the mucosal tissues [1,2].Lyophilisation has been used in pharmaceutical industries to improve the stability of formulations. The investigation of fundamental physical phenomena occurring during each step of freeze drying has enabled formulators to produce stable and well-designed freezedried pharmaceutical dosage forms [3]. Freeze dried products do not necessarily need to be refrigerated and can be stored at ambient temperatures. This will be favourable for labile drugs including vaccines and proteins [4].Lyophilisation comprises a freezing step where ice crystals form and the solute becomes extremely concentrated. As the temperature falls below the glass transition temperature (T g ), the system is changed into a viscous glass. Incomplete crystallization may, however, lead to sample collapse or formation of mixtures of different polymorphic forms that causes problems in characterization and manufacturing reproducibility. Frozen products can be categorized as either crystalline or amorphous glass in structure. Crystalline products have a distinct "eutectic" freezing/melting point which is referred to as the collapse temperature. Amorphous products have a corresponding "glass transition" temperature and they are much more difficult to freeze-dry. Even though most materials that are freeze dried are actually amorphous, the term "eutectic" is often used to define the freezing/melting point of sample [4].To optimise the process of solute crystallization during freezing, thermal treatment, or "annealing", will be advantageous. Annealing is the process of heating a sample above its 4 glass transition temperature (but below the eutectic and/or ice melting temperature) and allowing the glass to relax and crystallize. Metastable glass formation is possible depending on the f...

show abstract

Section: Introductionmentioning

confidence: 99%

Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs

Kianfar

Antonijević

Chowdhry

et al. 2013

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

show abstract

“…Orally disintegrating films may be options for incorporation of these components since they are convenient to use, and there is a large variety of substances that can be used to form the polymer matrix depending on the physicochemical properties of the active component (DIXIT; PUTHLI, 2009;NISHIGAKI et al, 2012). These films are mainly produced using natural macromolecules, such as starch (SHIMODA et al, 2009), proteins (CHEN et al, 2008, blends of chitosan and gelatin (ABRUZZO et al, 2012), microcrystalline cellulose and polyethylene glycol (NISHIGAKI et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of orally-disintegrating films for propolis delivery

Borges¹,

Tagliamento²,

Silva³

et al. 2013

Ciênc. Tecnol. Aliment.

View full text Add to dashboard Cite

“…One of these new solid dosage forms, pharmaceutical strip-film products, has received much attention because of several advantages including rapid disintegration and dissolution in the oral cavity and increased bioavailability (32)(33)(34)(35). In this work, we present a comparison between the basket method and the flow-through cell dissolution apparatus for the dissolution analysis of polymer strip-films containing dispersed particles of griseofulvin (GF), taken as a model Biopharmaceutical Classification System (BCS) class II drug, with the ultimate goal of discriminating drug dissolution with respect to drug particle size.…”

Section: Introductionmentioning

confidence: 99%

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

et al. 2012

View full text Add to dashboard Cite

Abstract. Recent interest in the development of drug particle-laden strip-films suggests the need for establishing standard regulatory tests for their dissolution. In this work, we consider the dissolution testing of griseofulvin (GF) particles, a poorly water-soluble compound, incorporated into a strip-film dosage form. The basket apparatus (USP I) and the flow-through cell dissolution apparatus (USP IV) were employed using 0.54% sodium dodecyl sulfate as the dissolution medium as per USP standard. Different rotational speeds and dissolution volumes were tested for the basket method while different cell patterns/ strip-film position and dissolution media flow rate were tested using the flow-through cell dissolution method. The USP I was not able to discriminate dissolution of GF particles with respect to particle size. On the other hand, in the USP IV, GF nanoparticles incorporated in strip-films exhibited enhancement in dissolution rates and dissolution extent compared with GF microparticles incorporated in strip-films. Within the range of patterns and flow rates used, the optimal discrimination behavior was obtained when the strip-film was layered between glass beads and a flow rate of 16 ml/min was used. These results demonstrate the superior discriminatory power of the USP IV and suggest that it could be employed as a testing device in the development of strip-films containing drug nanoparticles.

show abstract

Oral strip technology: Overview and future potential

Cited by 487 publications

References 51 publications

Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs

Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs

Development and characterization of orally-disintegrating films for propolis delivery

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

Contact Info

Product

Resources

About