Oral submucous fibrosis patients have altered levels of cytokine production

Haque, MF; Meghji, S; Khitab, Umar; Harris, Malcolm

doi:10.1034/j.1600-0714.2000.290304.x

Cited by 99 publications

(80 citation statements)

References 25 publications

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“…They are well known to be involved in many fibrotic diseases (Table-3) of lung, liver, kidney, pancreas, and systemic aggressive fibromatosis as well as colloid and hypertrophic scar formation (8)(9)(10)(11)(12)(13). With the exception of a reported series from our group including a smaller patient population (14) to our knowledge there have been no further investigations of serum cytokine levels in PD.…”

Section: Commentscontrasting

confidence: 39%

Significant alterations of serum cytokine levels in patients with Peyronie's disease

et al. 2008

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Objective: To determine the expression of the cytokines transforming growth factor-β1 (TGF-β1), interferon-γ (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in serum from patients with Peyronie's disease (PD) compared to healthy controls. Materials and Methods: Ninety-one consecutive PD patients aged 20 -74 years were included in this study. All patients were diagnosed with symptomatic PD for the first time and had a palpable penile plaque. The patients previously had the disease for 6 -72 months. None of the patients had a severe infectious disease or known systemic illness. For cytokine analyses, peripheral venous blood samples were obtained before treatment. Fifty healthy male blood donors aged 22 -64 years served as the control group. TGF-β1, IFN-γ, Il-6, and TNF-α were analyzed quantitatively with commercial immunoassays. Results: Mean cytokine levels in serum from patients were increased for TGF-β1 and IFN-γ compared to healthy controls. The difference for TGF-β1 was considered statistically significant (p < 0.001). IL-6 was not detectable in PD patients (p < 0.01) and TNF-α was decreased (p < 0.0001). Conclusion:The significantly elevated serum level of the profibrotic TGF-β1 cytokine underscores the effect of cytokines in the pathophysiology of PD. The significantly decreased TNF-α serum level suggested no acute immunomodulatory process. Therefore, the relevance for therapeutic administration of TNF-α should be further investigated. Quantification of TGF-β1 in serum of PD patients provides a possible diagnostic tool and target for therapy. The data on altered cytokine levels in PD patients also provide a new understanding for etiopathogenesis of PD, which warrants further investigation.

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Section: Commentscontrasting

confidence: 39%

Significant alterations of serum cytokine levels in patients with Peyronie's disease

et al. 2008

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“…As the oral mucosa is directly exposed to the copper challenge in the chewers, its effect may well be local. These different growth characteristics may either be due to the direct effects of the ingredients of the areca nut or they may be secondary to the inflammatory factors which are mediated by the areca nut, such as IL-1, TGF-, IGF and EG [14].…”

Section: Referencesmentioning

confidence: 99%

Estimation of the Serum and the Salivary Trace Elements in OSMF Patients

Kode

Karjodkar²

2013

JCDR

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Objectives: Gutkha packets contain trace elements like copper, zinc, iron and magnesium. This study compared the levels of the trace elements in patients with gutkha eating habits with or without oral submucous fibrosis and in healthy patients.Study Design: A total of 75 patients were included in this study and they were divided into three groups; the individuals with a history of gutkha intake with OSMF, the individuals with a his tory of gutkha intake without OSMF and apparently healthy individuals without OSMF and without any habits.Blood and saliva was collected and they were subjected for analysis by using atomic absorption spectrometry and a differ ential pulse anodic stripping voltmeter. Results:The results were tabulated and they were subjected to a statistical analysis. Conclusion:There was a significant difference in the serum Mg and Fe levels between the patients with habits and the normal healthy individuals. A significant difference was observed in the serum zinc levels in the patients with habits with and without OSMF. Altered serum trace element levels are documented in malignant cases and they are considered to be good biomarkers for malignancies. The serum copper and Zn levels and the Cu/ Zn ratio in OSMF patients can be considered as the markers which show a susceptibility towards cancer.

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“…Exposure to environment toxicants during early stages of immunological development has been demonstrated to compromise immunity and increase susceptibility to infections (Dietert & Dewitt, 2010). Clinical findings have linked areca chewing and the deregulation of T-cell-mediated immune responses in AQ chewers and oral cancer patients (Changrani & Gany, 2005;Haque et al, 2000). However, compared to the rich data on the influence of chewing areca nuts to the oral mucosa and matured T-cells, little is known about the impact of areca nut ingredients on the immune system under development.…”

Section: Introductionmentioning

confidence: 99%

Impairment of thymocyte function via induction of apoptosis by areca nut extract

Lee

Lin

Liu

et al. 2013

Journal of Immunotoxicology

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Areca quid (AQ) chewing is a popular oral habit, especially in Southeast Asia cultures, in which children may be engaged in the addictive habit early in their lives. Extracts of areca nuts, the main component of AQ, have been shown to affect the functionality of T-cells. However, the potential influence of ANE on the development of T-cells is unknown. This study, therefore, investigated the impact of areca nut extracts (ANE) on thymocytes and the potential mechanisms of action. Mice administered intraperitoneally with ANE at 1, 5, or 25 mg/kg daily for 5 days showed significant dose-dependent reductions in thymocyte viability. A marked decrease in the total number of thymocytes and the proportion of thymic CD4 þ CD8þ cells was observed in the 25 mg ANE/kg-treated mice, whereas the proportion of CD4 and CD8 single positive and CD4À CD8 À cells was significantly increased. Further examination on the functionality of thymocytes showed that ANE suppress IL-2 production both ex vivo and in vitro. These results suggest that ANE may attenuate the development and functionality of thymic T-cells. ANE also directly induced apoptosis in thymic T-cells through activation of casapase-3 and apoptosis inducing factor (AIF). Collectively, the data suggested that the thymus is a sensitive target to ANE. Early exposure to ANE may interfere with the development and functionality of thymic T-cells.

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Oral submucous fibrosis patients have altered levels of cytokine production

Cited by 99 publications

References 25 publications

Significant alterations of serum cytokine levels in patients with Peyronie's disease

Significant alterations of serum cytokine levels in patients with Peyronie's disease

Estimation of the Serum and the Salivary Trace Elements in OSMF Patients

Impairment of thymocyte function via induction of apoptosis by areca nut extract

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