2012
DOI: 10.1007/s00595-012-0288-4
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Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study

Abstract: Oral supplementation of BCAA reduces early recurrence after hepatic resection in patients with HCC. This treatment regimen offers potential benefits for clinical use in such patients, even in cases with a well-preserved preoperative liver function.

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Cited by 64 publications
(90 citation statements)
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“…Recently, a randomized trial showed that BCAA supplementation after hepatectomy promoted rapid improvement in protein metabolism and inhibited progression to liver cirrhosis [74] . Furthermore, another randomized trial showed that oral BCAA supplementation after hepatectomy for HCC significantly reduced the 30 month recurrence of HCC (28.5% vs 55.7%, P = 0.044) [75] . Perioperative BCAA treatment in patients undergoing hepatectomy was also shown to contribute to shorter hospital stay and quicker improvement of liver function during the early postoperative period [76] and to improve postoperative quality of life by restoring and maintaining nutritional status and whole-body kinetics [77] .…”
Section: Bcaas For Liver Cirrhosismentioning
confidence: 99%
“…Recently, a randomized trial showed that BCAA supplementation after hepatectomy promoted rapid improvement in protein metabolism and inhibited progression to liver cirrhosis [74] . Furthermore, another randomized trial showed that oral BCAA supplementation after hepatectomy for HCC significantly reduced the 30 month recurrence of HCC (28.5% vs 55.7%, P = 0.044) [75] . Perioperative BCAA treatment in patients undergoing hepatectomy was also shown to contribute to shorter hospital stay and quicker improvement of liver function during the early postoperative period [76] and to improve postoperative quality of life by restoring and maintaining nutritional status and whole-body kinetics [77] .…”
Section: Bcaas For Liver Cirrhosismentioning
confidence: 99%
“…In addition, BCAA supplementation can help in the management of HCC patients since most HCC patients have underlying LC (24,27,36,37). However, whether early interventional therapy using BCAA granules in patients with HCC can improve survival remains unclear.…”
Section: Discussionmentioning
confidence: 97%
“…Recently, some prospective clinical studies demonstrated that BCAA formulations can prevent HCC carcinogenesis (Kobayashi et al 2008) and recurrence (Ichikawa et al 2012a). The mechanism that underlies these phenomena is thought to involve immunity (Kakazu et recurrence times incipient-1 1-2 2-3 3-4 4-5 5-6 6-7 7-8 8> E 2012b), antiapoptotic (Kuwahata et al 2012) and other factors (Yoshiji et al 2009;Hagiwara et al 2012;Miuma et al 2012;Shimizu et al 2012).…”
Section: Discussionmentioning
confidence: 99%