Oral Supplementation of Phosphatidylcholine Attenuates the Onset of a Diet-Induced Metabolic Dysfunction–Associated Steatohepatitis in Female C57BL/6J Mice

Sánchez, Victor; Baumann, Anja; Brandt, Annette; Wodak, Maximilian F.; Staltner, Raphaela; Bergheim, Ina

doi:10.1016/j.jcmgh.2024.01.009

Cited by 5 publications

(1 citation statement)

References 61 publications

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“…In the presence of acyl-CoA, lysophosphatidylcholine acyltransferase can convert LPC to PC [47]. Some digestive system diseases such as inflammatory bowel disease [48], nonalcoholic fatty liver disease [49], and sclerosing cholangitis [50] are associated with decreased expression levels of LPC or PC. 1Alphahydroxyvitamin D3 is a derivative of vitamin D3.…”

Section: Analysis Of Key Differentially Abundant Urine Metabolites An...mentioning

confidence: 99%

Metabolite and Gut Microbiota Profiles in Patients with Functional Dyspepsia: An Integrative Multi-omics Analysis

Wen,

Liang,

et al. 2024

Preprint

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Background: The pathophysiology of functional dyspepsia (FD) remains insufficiently understood, and the pain and economic constraints associated with endoscopic examinations hinder the precise definition and treatment of this disorder. Exploring the potential of multi-omics biomarkers for FD could yield promising targets for effectively diagnosing and treating this condition. Methods: We recruited 54 FD patients and 29 healthy volunteers and characterized their gut microbiota by shotgun metagenomic sequencing and their serum and urine metabolites by liquid chromatography-mass spectrometry (LC-MS). Results: We identified the changes in circulating metabolites associated with FD and linked to the gut microbial alterations. Among the differential circulating metabolites, we particularly highlighted the strong association of L-glutamate deficiency with the severity of FD symptoms and its strong predictive value for FD. Although no significant changes were noted in the gut microbial community structure of the FD samples, this might be attributed to symptom overlap between epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS). However, significant alterations in the abundance of certain species were observed, including a substantial increase in the abundance of Streptococcus in the digestive tract of patients with FD. Finally, a cross-omics correlation network integrating metabolomic data with microbial community abundance was established, uncovering potential host-microbe-metabolite interactions. Conclusions: This work provides the first comprehensive description of the disrupted state of blood and urine metabolite composition and gut microbiota in patients with FD. These findings potentially offer promising targets for the diagnosis and treatment of this condition through a multi-omics approach, with particular emphasis on serum metabolomics.

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Section: Analysis Of Key Differentially Abundant Urine Metabolites An...mentioning

confidence: 99%

Metabolite and Gut Microbiota Profiles in Patients with Functional Dyspepsia: An Integrative Multi-omics Analysis

Wen,

Liang,

et al. 2024

Preprint

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A Nutraceutical Mechanistic Model Receives a Gut Check

Hand

2024

Cellular and Molecular Gastroenterology and Hepatology

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Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)

Sánchez,

Baumann,

Kromm

et al. 2024

Mol Med

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Background Chronic alcohol intake is associated with alterations of choline metabolism in various tissues. Here, we assessed if an oral choline supplementation attenuated the development of alcohol-related liver disease (ALD) in mice. Methods Female C57BL/6 J mice (n = 8/group) were either pair-fed a liquid control diet, or a Lieber DeCarli liquid diet (5% ethanol) ± 2.7 g choline/kg diet for 29 days. Liver damage, markers of intestinal permeability and intestinal microbiota composition were determined. Moreover, the effects of choline on ethanol-induced intestinal permeability were assessed in an ex vivo model. Results ALD development as determined by liver histology and assessing markers of inflammation (e.g., nitric oxide, interleukin 6 and 4-hydroxynonenal protein adducts) was attenuated by the supplementation of choline. Intestinal permeability in small intestine being significantly higher in ethanol-fed mice was at the level of controls in ethanol-fed mice receiving choline. In contrast, no effects of the choline supplementation were found on intestinal microbiota composition. Choline also significantly attenuated the ethanol-induced intestinal barrier dysfunction in small intestinal tissue ex vivo, an effect almost entirely abolished by the choline oxidase inhibitor dimbunol. Conclusion Our results suggest that an oral choline supplementation attenuates the development of ALD in mice and is related to a protection from intestinal barrier dysfunction.

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Oral Supplementation of Phosphatidylcholine Attenuates the Onset of a Diet-Induced Metabolic Dysfunction–Associated Steatohepatitis in Female C57BL/6J Mice

Cited by 5 publications

References 61 publications

Metabolite and Gut Microbiota Profiles in Patients with Functional Dyspepsia: An Integrative Multi-omics Analysis

Metabolite and Gut Microbiota Profiles in Patients with Functional Dyspepsia: An Integrative Multi-omics Analysis

A Nutraceutical Mechanistic Model Receives a Gut Check

Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)

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