Oral tongue cancer in young patients: A matched analysis

Garavello, Werner; Spreafico, Roberto; Gaini, Renato Maria

doi:10.1016/j.oraloncology.2006.10.013

Cited by 126 publications

(148 citation statements)

References 16 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…Other aspects of the disease also differ between young and old patients, for example the male to female ratio is lower in the younger group (11). SCCHN has been described in some reports as being more aggressive in younger patients (12,13), whereas other reports have not found any difference, or even seen better survival in young patients (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes

Rentoft

Laurell²,

Coates³

et al. 2009

Int J Oncol

View full text Add to dashboard Cite

Abstract.A subgroup of patients with squamous cell carcinoma of the head and neck (SCCHN) comprise young persons under the age of 40, who have not been heavily exposed to the classical risk factors, smoking and alcohol. The number of SCCHN in young adults, particularly tongue tumours, is increasing in several parts of the world. Here we employed a novel gene expression array methodology specifically developed for analysis of degraded RNA and investigated the expression of 502 cancer-related genes in archival paraffin-embedded SCCHN of the tongue from young (≤40) and elderly patients (≥50). Genes detected as de-regulated in tumours compared to non-malignant controls were in concordance with results from earlier studies of fresh frozen material. No genes were detected as significantly differentially expressed between young and old patients suggesting that the overall pathobiology of SCCHN is similar in young and old. Unsupervised clustering divided tumours into three groups, irrespective of age, where several differentially expressed DNA repair genes were a prominent separation factor. High levels of DNA repair genes associated with impaired therapeutic response to radiation, suggesting that DNA repair genes play a role in clinical outcome after radiotherapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes

Rentoft

Laurell²,

Coates³

et al. 2009

Int J Oncol

View full text Add to dashboard Cite

show abstract

“…HNSCC comprises malignant epithelial neoplasms that arise in the paranasal sinuses, nasal cavity, oral cavity, pharynx and larynx, and generally affects males between the sixth and ninth decades of life following long-term exposure to smoking and alcohol consumption (3). However, an increase in the incidence of head and neck cancer among patients under the age of 45 years has been reported worldwide (4)(5)(6)(7)(8)(9)(10). Some studies suggest that in younger patients, HNSCC arises regardless of the classical risk factors (4)(5)(6)(7)(8)10).…”

Section: Introductionmentioning

confidence: 99%

“…However, an increase in the incidence of head and neck cancer among patients under the age of 45 years has been reported worldwide (4)(5)(6)(7)(8)(9)(10). Some studies suggest that in younger patients, HNSCC arises regardless of the classical risk factors (4)(5)(6)(7)(8)10). HPV infection has been suggested as a possible etiologic factor for such cases (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

et al. 2012

View full text Add to dashboard Cite

Abstract.Recently, high-risk human papillomavirus (HPV) has emerged as a possible agent associated with head and neck squamous cell carcinoma (HNSCC) in younger patients. Therefore, the purpose of the present study was to assess the effect of age on the distribution of HPV-16/18 in HNSCC, together with the impact of the virus on patient prognosis. A longitudinal prospective study was used adjusted for age, gender, TNM staging, smoking status and alcohol consumption. HPV was detected by PCR with consensus primers. Results showed there was no difference in the frequency of HPV-16/18 positivity when younger patients were compared to the older patients. No association was found among highrisk HPV positivity, gender, smoking habit and anatomical site. High-risk HPV was associated with advanced TNM in bivariate analyses; however, it did not impact on survival. Only TNM staging was associated with risk of mortality. Our study supports the theory that age does not affect the presence of HPV-16/18 in HNSCC and has no impact on patient prognosis. The incidence of HNSCC among patients under the age of 45 years is reportedly on the increase worldwide. The factors associated with HNSCC in younger adults are not well established. Findings of this study indicate that HPV-16/18 may not play a role in HNSCC patients under the age of 45 years.

show abstract

“…Durante la última década, los investigadores han demostrado un aumento de la incidencia del carcinoma de células escamosas de lengua en pacientes menores de 45 años, tanto en Estados Unidos como en Europa [5][6][7] .…”

Section: Introductionunclassified

“…Sin embargo, otros estudios demuestran un mayor número de recidivas entre los pacientes jóvenes, así como, un mayor número de muertes causadas por el tumor inicial. Un ejemplo es el estudio de Garavello y cols 6 que demuestra 50% de muertes causadas por cáncer de lengua entre los pacientes jóvenes frente a 23% de muertes entre los mayores de 40 años 6 .…”

Section: Introductionunclassified