“…The influence of age and gender on the prognosis of OSCC patients has been investigated in some recent studies, but the results were generally controversial, which reflect variations in a large number of factors, such as the time span allowed for the collection of cases, samples size, prevalence of risk factors, time elapsed since diagnosis, access to healthcare services, geographic location, and global trends in OSCC. Some of the studies claimed that prognosis at a young age was similar (Blanchard et al, ; de Morais et al, ; Farquhar et al, ; Martinez et al, ), worse (Zhang et al, ), or better (Sommers et al, ) compared to that of older patients. We found that male gender was associated with a poorer prognosis, which was in accordance with previous studies (Ong, Murphy, Smith, Kanatas, & Mitchell, ; Santos et al, ).…”