1998
DOI: 10.1016/s0278-6915(98)00065-9
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Oral Toxicity of Bis(2-Ethylhexyl) Phthalate During Pregnancy and Suckling in the Long–Evans Rat

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Cited by 211 publications
(95 citation statements)
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“…Like DEHP, DBP is also a testicular toxicant and causes reproductive tract malformations in male rats after in utero exposure (Arcadi et al 1998;Gray et al 1999;Moore et al 2001;Mylchreest et al 1998Mylchreest et al , 1999Parks et al 2000). Among the structurally related phthalates, DEHP, DBP, DPP, and DHP cause testicular atrophy and are both female and male reproductive toxicants in rodents (Heindel and Powell 1992).…”
Section: Reproductive and Developmental Toxicity In Animal Modelsmentioning
confidence: 99%
“…Like DEHP, DBP is also a testicular toxicant and causes reproductive tract malformations in male rats after in utero exposure (Arcadi et al 1998;Gray et al 1999;Moore et al 2001;Mylchreest et al 1998Mylchreest et al , 1999Parks et al 2000). Among the structurally related phthalates, DEHP, DBP, DPP, and DHP cause testicular atrophy and are both female and male reproductive toxicants in rodents (Heindel and Powell 1992).…”
Section: Reproductive and Developmental Toxicity In Animal Modelsmentioning
confidence: 99%
“…Young rats are more susceptible than older rats (Sjö berg et al 1986;Poon et al 1997) and perinatal exposure to 325 ml DEHP/l drinking water for 42 days results in disorganisation of seminiferous tubules and detachment of the spermatogonial cells (Arcadi et al 1998). It has been reported that the active DEHP-metabolite MEHP specifically disrupt the FSHinduced cyclic AMP synthesis in cultured rat adult Sertoli cells (Grasso et al 1993).…”
Section: Discussionmentioning
confidence: 99%
“…Since they are physically bound to the polymer chains, PEs may be released into the environment during the production, use, or incineration of polymeric materials containing them (1,2). Due to the potential risks of PEs to human health and the environment (3,4), several of them have been included in the list of priority pollutants by different national and international organizations. For example, the United States (US) Environmental Protection Agency (EPA) has established a maximum admissible concentration (MAC) of 6 µgL −1 for di-ethylhexyl phthalate (DEHP) in water (5).…”
Section: Introductionmentioning
confidence: 99%