Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review

Hadrup, Niels; Lam, Henrik Rye

doi:10.1016/j.yrtph.2013.11.002

Cited by 464 publications

(288 citation statements)

References 63 publications

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“…803 Argyria involves the deposition of silver granules in the skin, mucous membranes, and internal organs, including the central nervous system, resulting in the hallmark bluegray discoloration of the skin generally associated with chronic low-dose exposure to silver-containing products. Consumption of large doses of colloidal silver can result in significant morbidity including gastrointestinal ulceration, hemolysis, agranulocytosis, and neural toxicity.…”

Section: S93mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

557

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: S93mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

557

888

View full text Add to dashboard Cite

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“…[143][144][145] In order to make silver NPs more biocompatible, Marcato et al fabricated biogenic silver NPs (AgNP bio ) with Mg/Al LDHs. 146 They evaluated the biocompatibility of free AgNP bio , LDHs, and AgNP bio LDHs against a lung fibroblast cell line (V79), and found that AgNP bio caused 50% cell death at a concentration of 45 μmol⋅L −1 .…”

Section: Biogenic Silver Nanoparticle-fabricated Layered Double Hydromentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

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“…It is one of the most prominent therapeutic elemental agent in medicine for surgical infections and infectious diseases. The tangible advantages of silver have a bigger weightage than the intangible risk factors [1].…”

Section: Silver Nano Particles (Snps)mentioning

confidence: 99%

A review on preparation methods of SNPs and their biomedical applications

Ut¹,

Mk²,

Gvsn³

2017

Front Nanosci Nanotech

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Researchers have identified Silver Nano Particles (SNPs) as a key area of interest because of their unique shape and size dependent biomedical properties. They have discovered and invented a variety of methods for the synthesis of SNPs such as microwave irradiation techniques, laser ablation synthesis, biological synthesis, photochemical synthesis and chemical synthesis etc. In this review paper we overview the preparation of SNPs through various synthesis methods and also their applications in the bio-medical field. The main aim of this paper is to keep up to date with the myriad ongoing synthesis methods of synthesis of NPs and also examine their applications especially in the field of medicine. Silver Nano Particles (SNPs)Silver (Ag) is a white colored, lustrous looking, physically soft, transition element metal having high thermal and electrical conductivity. It has been used by humans earlier than the recorded history due to its ornamental, medical and therapeutic benefits even before realizing that microbes are the causative agents of infections. It is used by people in many forms such as solutions, foils, coins, vessels, sutures, and in colloids such as lotions, ointments etc. It is one of the most prominent therapeutic elemental agent in medicine for surgical infections and infectious diseases. The tangible advantages of silver have a bigger weightage than the intangible risk factors [1].Nanoscience is a novel multidisciplinary subject that depends on the basic physical and chemical properties displayed by nano level objects [2,3]. Nanoparticles have been shown to display amazing electromagnetic, surface optical and chemically catalytic characteristics than the macro bulk material owing to their extremely low volume to surface area ratio [4,5]. Metal nanoparticles such as silver show different colors due to their Surface Plasmon Resonance (SPR) phenomenon. It is a group oscillatory behavior of the free electrons of the metal nanoparticles having the same frequency of the light wave interactions, resulting in resonance, causing the SPR band to form in the infrared and visible region [6]. Nanoparticles, especially the metallic ones, whose production can be done through various methods, the usual ones being physical and chemical methods. The above-mentioned methods produce high purity, well-defined nanoparticles, but the reagents used in the synthesis are hazardous, energy consuming, expensive, toxic and not suitable for physiological or ecological applications. Research regarding the synthesis of metal nanoparticles was extensively covered in the past three decades, but research of nanosynthesis , based on plant extracts, bloomed only in the last ten years [7][8][9][10][11][12][13].Silver nanoparticles are finding themselves in the limelight due to their biological, chemical and physical properties that contributes to the bactericidal and fungicidal effects, catalytic activity and finds applications in nanobiotechnological research [14,15]. Doctors are beginning to use them in wound dressings as an...

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Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review

Cited by 464 publications

References 63 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Inorganic nanolayers: structure, preparation, and biomedical applications

A review on preparation methods of SNPs and their biomedical applications

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Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review

Cited by 464 publications

References 63 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Inorganic nanolayers: structure, preparation, and&nbsp;biomedical applications

A review on preparation methods of SNPs and their biomedical applications

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Product

Resources

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Inorganic nanolayers: structure, preparation, and biomedical applications